Neurocognitive performance in patients with depression compared to healthy controls: Association of clinical variables and remission state
Cognitive impairment in Major Depressive Disorder (MDD) has been postulated to persist into remission. However, inconsistent definitions of clinical remission, patterns and influencing factors, isolated cognitive tasks, and the lack of appropriately matched controls (HCs) present significant limitat...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
2019
|
| In: |
Psychiatry research
Year: 2019, Volume: 271, Pages: 343-350 |
| ISSN: | 1872-7123 |
| DOI: | 10.1016/j.psychres.2018.11.047 |
| Online Access: | Verlag, Volltext: https://doi.org/10.1016/j.psychres.2018.11.047 Verlag, Volltext: http://www.sciencedirect.com/science/article/pii/S0165178118305031 
|
| Author Notes: | Thea Marianne Grützner, Anuradha Sharma, Lena Listunova, Marina Bartolovic, Matthias Weisbrod, Daniela Roesch-Ely |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1666184551 | ||
| 003 | DE-627 | ||
| 005 | 20220816160241.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 190523s2019 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/j.psychres.2018.11.047 |2 doi | |
| 035 | |a (DE-627)1666184551 | ||
| 035 | |a (DE-599)KXP1666184551 | ||
| 035 | |a (OCoLC)1341225296 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Grützner, Thea M. |e VerfasserIn |0 (DE-588)118665824X |0 (DE-627)1665949171 |4 aut | |
| 245 | 1 | 0 | |a Neurocognitive performance in patients with depression compared to healthy controls |b Association of clinical variables and remission state |c Thea Marianne Grützner, Anuradha Sharma, Lena Listunova, Marina Bartolovic, Matthias Weisbrod, Daniela Roesch-Ely |
| 264 | 1 | |c 2019 | |
| 300 | |a 8 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Available online 20 November 2018 | ||
| 500 | |a Gesehen am 23.05.2019 | ||
| 520 | |a Cognitive impairment in Major Depressive Disorder (MDD) has been postulated to persist into remission. However, inconsistent definitions of clinical remission, patterns and influencing factors, isolated cognitive tasks, and the lack of appropriately matched controls (HCs) present significant limitations of previous studies. Furthermore, studies investigating cognition in partially remitted patients are particularly scarce. This study compares the cognition of MDD patients (N=65) and HCs (N=65), matched by one-to-one recruitment strategy for age, sex, and education (ages 19-60). The neuropsychological (NPS) performance was measured via an extensive NPS-test battery and analysed retrospectively, accounting for demographic and clinical variables. Full remission was defined as HAMD cut off ≤7, partial remission as HAMD 8-18. The findings show entire MDD group and partially remitted MDD with significantly poorer NPS performance compared to HCs, while remitted MDD patients did not differ significantly from HCs. This underscores how critical a clear definition of remission is to compare studies on MDD. The clinical variable ‘number of hospitalizations’ had a significant effect on cognition, whereas current symptom severity did not correlate with performance on any cognitive domain. Higher number of hospitalizations may be associated with higher burden of illness and greater neurobiological “scar effects”. | ||
| 650 | 4 | |a Cognitive impairment | |
| 650 | 4 | |a Hospitalization | |
| 650 | 4 | |a Major depressive disorder | |
| 650 | 4 | |a Neuropsychological performance | |
| 700 | 1 | |a Sharma, Anuradha |d 1982- |e VerfasserIn |0 (DE-588)102153689X |0 (DE-627)715820338 |0 (DE-576)362842272 |4 aut | |
| 700 | 1 | |a Bartolovic, Marina |d 1982- |e VerfasserIn |0 (DE-588)1163042862 |0 (DE-627)1027286658 |0 (DE-576)507760794 |4 aut | |
| 700 | 1 | |a Weisbrod, Matthias |d 1960- |e VerfasserIn |0 (DE-588)1018045562 |0 (DE-627)690499647 |0 (DE-576)170710211 |4 aut | |
| 700 | 1 | |a Roesch-Ely, Daniela |d 1971- |e VerfasserIn |0 (DE-588)124376878 |0 (DE-627)363305025 |0 (DE-576)294144552 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Psychiatry research |d Amsterdam [u.a.] : Elsevier Science, 1979 |g 271(2019), Seite 343-350 |h Online-Ressource |w (DE-627)306661446 |w (DE-600)1500675-X |w (DE-576)08198698X |x 1872-7123 |7 nnas |a Neurocognitive performance in patients with depression compared to healthy controls Association of clinical variables and remission state |
| 773 | 1 | 8 | |g volume:271 |g year:2019 |g pages:343-350 |g extent:8 |a Neurocognitive performance in patients with depression compared to healthy controls Association of clinical variables and remission state |
| 856 | 4 | 0 | |u https://doi.org/10.1016/j.psychres.2018.11.047 |x Verlag |x Resolving-System |3 Volltext |
| 856 | 4 | 0 | |u http://www.sciencedirect.com/science/article/pii/S0165178118305031 |x Verlag |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20190523 | ||
| 993 | |a Article | ||
| 994 | |a 2019 | ||
| 998 | |g 124376878 |a Roesch-Ely, Daniela |m 124376878:Roesch-Ely, Daniela |d 910000 |d 910600 |e 910000PR124376878 |e 910600PR124376878 |k 0/910000/ |k 1/910000/910600/ |p 6 |y j | ||
| 998 | |g 1018045562 |a Weisbrod, Matthias |m 1018045562:Weisbrod, Matthias |d 910000 |d 910600 |e 910000PW1018045562 |e 910600PW1018045562 |k 0/910000/ |k 1/910000/910600/ |p 5 | ||
| 998 | |g 1163042862 |a Bartolovic, Marina |m 1163042862:Bartolovic, Marina |d 910000 |d 910600 |e 910000PB1163042862 |e 910600PB1163042862 |k 0/910000/ |k 1/910000/910600/ |p 4 | ||
| 998 | |g 102153689X |a Sharma, Anuradha |m 102153689X:Sharma, Anuradha |d 910000 |d 913000 |e 910000PS102153689X |e 913000PS102153689X |k 0/910000/ |k 1/910000/913000/ |p 2 | ||
| 998 | |g 118665824X |a Grützner, Thea M. |m 118665824X:Grützner, Thea M. |d 50000 |e 50000PG118665824X |k 0/50000/ |p 1 |x j | ||
| 999 | |a KXP-PPN1666184551 |e 347898260X | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"type":{"media":"Online-Ressource","bibl":"article-journal"},"origin":[{"dateIssuedDisp":"2019","dateIssuedKey":"2019"}],"person":[{"given":"Thea M.","roleDisplay":"VerfasserIn","role":"aut","display":"Grützner, Thea M.","family":"Grützner"},{"role":"aut","roleDisplay":"VerfasserIn","given":"Anuradha","family":"Sharma","display":"Sharma, Anuradha"},{"display":"Bartolovic, Marina","family":"Bartolovic","given":"Marina","roleDisplay":"VerfasserIn","role":"aut"},{"display":"Weisbrod, Matthias","family":"Weisbrod","roleDisplay":"VerfasserIn","given":"Matthias","role":"aut"},{"roleDisplay":"VerfasserIn","given":"Daniela","role":"aut","display":"Roesch-Ely, Daniela","family":"Roesch-Ely"}],"title":[{"title_sort":"Neurocognitive performance in patients with depression compared to healthy controls","title":"Neurocognitive performance in patients with depression compared to healthy controls","subtitle":"Association of clinical variables and remission state"}],"physDesc":[{"extent":"8 S."}],"note":["Available online 20 November 2018","Gesehen am 23.05.2019"],"id":{"doi":["10.1016/j.psychres.2018.11.047"],"eki":["1666184551"]},"relHost":[{"pubHistory":["1.1979 -"],"title":[{"title":"Psychiatry research","title_sort":"Psychiatry research"}],"origin":[{"publisherPlace":"Amsterdam [u.a.]","dateIssuedKey":"1979","dateIssuedDisp":"1979-","publisher":"Elsevier Science"}],"language":["eng"],"part":{"volume":"271","year":"2019","extent":"8","pages":"343-350","text":"271(2019), Seite 343-350"},"physDesc":[{"extent":"Online-Ressource"}],"disp":"Neurocognitive performance in patients with depression compared to healthy controls Association of clinical variables and remission statePsychiatry research","type":{"media":"Online-Ressource","bibl":"periodical"},"recId":"306661446","note":["Gesehen am 24.03.2023"],"id":{"zdb":["1500675-X"],"eki":["306661446"],"issn":["1872-7123"]}}],"name":{"displayForm":["Thea Marianne Grützner, Anuradha Sharma, Lena Listunova, Marina Bartolovic, Matthias Weisbrod, Daniela Roesch-Ely"]},"recId":"1666184551","language":["eng"]} | ||
| SRT | |a GRUETZNERTNEUROCOGNI2019 | ||