Combining adhesive nanostructured surfaces and costimulatory signals to increase T Cell activation
Adoptive cell therapies are showing very promising results in the fight against cancer. However, these therapies are expensive and technically challenging in part due to the need of a large number of specific T cells, which must be activated and expanded in vitro. Here we describe a method to activa...
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| Hauptverfasser: | , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
8 August 2018
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| In: |
Nano letters
Year: 2018, Jahrgang: 18, Heft: 9, Pages: 5899-5904 |
| ISSN: | 1530-6992 |
| DOI: | 10.1021/acs.nanolett.8b02588 |
| Online-Zugang: | Verlag, Volltext: https://doi.org/10.1021/acs.nanolett.8b02588
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| Verfasserangaben: | Judith Guasch, Marco Hoffmann, Jennifer Diemer, Hossein Riahinezhad, Stefanie Neubauer, Horst Kessler, and Joachim P. Spatz |
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| 520 | |a Adoptive cell therapies are showing very promising results in the fight against cancer. However, these therapies are expensive and technically challenging in part due to the need of a large number of specific T cells, which must be activated and expanded in vitro. Here we describe a method to activate primary human T cells using a combination of nanostructured surfaces functionalized with the stimulating anti-CD3 antibody and the peptidic sequence arginine-glycine-aspartic acid, as well as costimulatory agents (anti-CD28 antibody and a cocktail of phorbol 12-myristate 13-acetate, ionomycin, and protein transport inhibitors). Thus, we propose a method that combines nanotechnology with cell biology procedures to efficiently produce T cells in the laboratory, challenging the current state-of-the-art expansion methodologies. | ||
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