Clinical management of blood-brain barrier disruptions after active raster-scanned carbon ion re-radiotherapy in patients with recurrent head-and-neck cancer
Purpose: The aim of the current evaluation was to assess central nervous system necrosis (CNSN) after re-irradiation with carbon ions (CR) in two-hundred seventeen (n = 217) patients with recurrent head-and-neck cancer (HNC). Methods: Thirty-six (n = 36) patients with CNSN were assessed retrospectiv...
Saved in:
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
19 March 2019
|
| In: |
Cancers
Year: 2019, Volume: 11, Issue: 3 |
| ISSN: | 2072-6694 |
| DOI: | 10.3390/cancers11030383 |
| Online Access: | Verlag, kostenfrei, Volltext: https://doi.org/10.3390/cancers11030383 Verlag, kostenfrei, Volltext: https://www.mdpi.com/2072-6694/11/3/383 
|
| Author Notes: | Thomas Held, Sati Akbaba, Kristin Lang, Semi Harrabi, Denise Bernhardt, Christian Freudlsperger, Steffen Kargus, Peter Plinkert, Stefan Rieken, Klaus Herfarth, Jürgen Debus and Sebastian Adeberg |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1666436429 | ||
| 003 | DE-627 | ||
| 005 | 20210816123016.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 190528s2019 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.3390/cancers11030383 |2 doi | |
| 035 | |a (DE-627)1666436429 | ||
| 035 | |a (DE-599)KXP1666436429 | ||
| 035 | |a (OCoLC)1264076368 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Held, Thomas |d 1990- |e VerfasserIn |0 (DE-588)1172053723 |0 (DE-627)104086970X |0 (DE-576)513977627 |4 aut | |
| 245 | 1 | 0 | |a Clinical management of blood-brain barrier disruptions after active raster-scanned carbon ion re-radiotherapy in patients with recurrent head-and-neck cancer |c Thomas Held, Sati Akbaba, Kristin Lang, Semi Harrabi, Denise Bernhardt, Christian Freudlsperger, Steffen Kargus, Peter Plinkert, Stefan Rieken, Klaus Herfarth, Jürgen Debus and Sebastian Adeberg |
| 264 | 1 | |c 19 March 2019 | |
| 300 | |a 10 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 28.05.2019 | ||
| 520 | |a Purpose: The aim of the current evaluation was to assess central nervous system necrosis (CNSN) after re-irradiation with carbon ions (CR) in two-hundred seventeen (n = 217) patients with recurrent head-and-neck cancer (HNC). Methods: Thirty-six (n = 36) patients with CNSN were assessed retrospectively regarding clinical symptoms and radiographic response. Results: CNSN were classified according to clinical management in line with the Common Terminology Criteria for Adverse Events (CTCAE) v5.0. At a median follow-up of 25.3 months (range 3.3 - 79.9 months), the median time interval until occurrence of grade I, II, and III CNSN was 9.2 months (range 2.8 - 75.0 months), 10.2 months (range 2.3 - 60.5 months), and 16.6 months (range 8.7 - 32.5 months), respectively. In one patient with an adenocarcinoma infiltrating the frontal lobe, an extensive CNSN grade IV was suspected but the patient declined surgical intervention. Radiographic response after treatment of CNSN grade I, II, and III, defined as ≥25% reduction of the T2 alteration on Magnetic Resonance Imaging (MRI), was observed in 4 (16.0%), 5 (29.4%), and 4 (80%) patients, respectively. Conclusion: CNSN occurred late and frequent after re-irradiation with carbon ions in patients with HNC infiltrating the base of skull. The clinical outcome with adequate treatment was encouraging but correct diagnosis of CNSN remains challenging. | ||
| 650 | 4 | |a carbon ions | |
| 650 | 4 | |a brain necrosis | |
| 650 | 4 | |a head and neck cancer | |
| 650 | 4 | |a particle therapy | |
| 650 | 4 | |a re-irradiation | |
| 700 | 1 | |a Akbaba, Sati |d 1987- |e VerfasserIn |0 (DE-588)1150864648 |0 (DE-627)1011125226 |0 (DE-576)497297116 |4 aut | |
| 700 | 1 | |a Uzun-Lang, Kristin |d 1986- |e VerfasserIn |0 (DE-588)106868237X |0 (DE-627)820592064 |0 (DE-576)428008569 |4 aut | |
| 700 | 1 | |a Harrabi, Semi B. |d 1986- |e VerfasserIn |0 (DE-588)1044730161 |0 (DE-627)772596034 |0 (DE-576)398081298 |4 aut | |
| 700 | 1 | |a Bernhardt, Denise |d 1987- |e VerfasserIn |0 (DE-588)1074875338 |0 (DE-627)832630691 |0 (DE-576)443070970 |4 aut | |
| 700 | 1 | |a Freudlsperger, Christian |d 1977- |e VerfasserIn |0 (DE-588)130275913 |0 (DE-627)589450751 |0 (DE-576)301504105 |4 aut | |
| 700 | 1 | |a Kargus, Steffen |d 1984- |e VerfasserIn |0 (DE-588)1036761266 |0 (DE-627)751687324 |0 (DE-576)386811970 |4 aut | |
| 700 | 1 | |a Plinkert, Peter K. |e VerfasserIn |0 (DE-588)1032658509 |0 (DE-627)739933043 |0 (DE-576)169008908 |4 aut | |
| 700 | 1 | |a Rieken, Stefan |d 1979- |e VerfasserIn |0 (DE-588)135553385 |0 (DE-627)567062570 |0 (DE-576)278641725 |4 aut | |
| 700 | 1 | |a Herfarth, Klaus |e VerfasserIn |0 (DE-588)1032757582 |0 (DE-627)739273116 |0 (DE-576)171352289 |4 aut | |
| 700 | 1 | |a Debus, Jürgen |d 1964- |e VerfasserIn |0 (DE-588)1022671421 |0 (DE-627)717025780 |0 (DE-576)365774944 |4 aut | |
| 700 | 1 | |a Adeberg, Sebastian |d 1984- |e VerfasserIn |0 (DE-588)1049743377 |0 (DE-627)782574467 |0 (DE-576)403727774 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Cancers |d Basel : MDPI, 2009 |g 11(2019,3) Artikel-Nummer 383, 10 Seiten |h Online-Ressource |w (DE-627)614095670 |w (DE-600)2527080-1 |w (DE-576)313958548 |x 2072-6694 |7 nnas |a Clinical management of blood-brain barrier disruptions after active raster-scanned carbon ion re-radiotherapy in patients with recurrent head-and-neck cancer |
| 773 | 1 | 8 | |g volume:11 |g year:2019 |g number:3 |g extent:10 |a Clinical management of blood-brain barrier disruptions after active raster-scanned carbon ion re-radiotherapy in patients with recurrent head-and-neck cancer |
| 856 | 4 | 0 | |u https://doi.org/10.3390/cancers11030383 |x Verlag |x Resolving-System |z kostenfrei |3 Volltext |
| 856 | 4 | 0 | |u https://www.mdpi.com/2072-6694/11/3/383 |x Verlag |z kostenfrei |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20190528 | ||
| 993 | |a Article | ||
| 994 | |a 2019 | ||
| 998 | |g 1049743377 |a Adeberg, Sebastian |m 1049743377:Adeberg, Sebastian |d 910000 |d 911400 |d 50000 |e 910000PA1049743377 |e 911400PA1049743377 |e 50000PA1049743377 |k 0/910000/ |k 1/910000/911400/ |k 0/50000/ |p 12 |y j | ||
| 998 | |g 1022671421 |a Debus, Jürgen |m 1022671421:Debus, Jürgen |d 910000 |d 911400 |e 910000PD1022671421 |e 911400PD1022671421 |k 0/910000/ |k 1/910000/911400/ |p 11 | ||
| 998 | |g 1032757582 |a Herfarth, Klaus |m 1032757582:Herfarth, Klaus |d 910000 |d 911400 |e 910000PH1032757582 |e 911400PH1032757582 |k 0/910000/ |k 1/910000/911400/ |p 10 | ||
| 998 | |g 135553385 |a Rieken, Stefan |m 135553385:Rieken, Stefan |d 910000 |d 911400 |e 910000PR135553385 |e 911400PR135553385 |k 0/910000/ |k 1/910000/911400/ |p 9 | ||
| 998 | |g 1032658509 |a Plinkert, Peter K. |m 1032658509:Plinkert, Peter K. |d 910000 |d 911000 |e 910000PP1032658509 |e 911000PP1032658509 |k 0/910000/ |k 1/910000/911000/ |p 8 | ||
| 998 | |g 1036761266 |a Kargus, Steffen |m 1036761266:Kargus, Steffen |d 910000 |d 910800 |e 910000PK1036761266 |e 910800PK1036761266 |k 0/910000/ |k 1/910000/910800/ |p 7 | ||
| 998 | |g 130275913 |a Freudlsperger, Christian |m 130275913:Freudlsperger, Christian |d 910000 |d 910800 |e 910000PF130275913 |e 910800PF130275913 |k 0/910000/ |k 1/910000/910800/ |p 6 | ||
| 998 | |g 1074875338 |a Bernhardt, Denise |m 1074875338:Bernhardt, Denise |d 910000 |d 911400 |e 910000PB1074875338 |e 911400PB1074875338 |k 0/910000/ |k 1/910000/911400/ |p 5 | ||
| 998 | |g 1044730161 |a Harrabi, Semi B. |m 1044730161:Harrabi, Semi B. |d 910000 |d 911400 |e 910000PH1044730161 |e 911400PH1044730161 |k 0/910000/ |k 1/910000/911400/ |p 4 | ||
| 998 | |g 106868237X |a Uzun-Lang, Kristin |m 106868237X:Uzun-Lang, Kristin |d 910000 |d 911400 |e 910000PU106868237X |e 911400PU106868237X |k 0/910000/ |k 1/910000/911400/ |p 3 | ||
| 998 | |g 1150864648 |a Akbaba, Sati |m 1150864648:Akbaba, Sati |d 910000 |d 911400 |e 910000PA1150864648 |e 911400PA1150864648 |k 0/910000/ |k 1/910000/911400/ |p 2 | ||
| 998 | |g 1172053723 |a Held, Thomas |m 1172053723:Held, Thomas |d 910000 |d 911400 |e 910000PH1172053723 |e 911400PH1172053723 |k 0/910000/ |k 1/910000/911400/ |p 1 |x j | ||
| 999 | |a KXP-PPN1666436429 |e 348002663X | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"name":{"displayForm":["Thomas Held, Sati Akbaba, Kristin Lang, Semi Harrabi, Denise Bernhardt, Christian Freudlsperger, Steffen Kargus, Peter Plinkert, Stefan Rieken, Klaus Herfarth, Jürgen Debus and Sebastian Adeberg"]},"note":["Gesehen am 28.05.2019"],"recId":"1666436429","physDesc":[{"extent":"10 S."}],"person":[{"family":"Held","display":"Held, Thomas","given":"Thomas","role":"aut"},{"role":"aut","family":"Akbaba","display":"Akbaba, Sati","given":"Sati"},{"given":"Kristin","family":"Uzun-Lang","display":"Uzun-Lang, Kristin","role":"aut"},{"display":"Harrabi, Semi B.","family":"Harrabi","given":"Semi B.","role":"aut"},{"role":"aut","family":"Bernhardt","display":"Bernhardt, Denise","given":"Denise"},{"family":"Freudlsperger","display":"Freudlsperger, Christian","given":"Christian","role":"aut"},{"display":"Kargus, Steffen","family":"Kargus","given":"Steffen","role":"aut"},{"display":"Plinkert, Peter K.","family":"Plinkert","given":"Peter K.","role":"aut"},{"given":"Stefan","family":"Rieken","display":"Rieken, Stefan","role":"aut"},{"family":"Herfarth","display":"Herfarth, Klaus","given":"Klaus","role":"aut"},{"display":"Debus, Jürgen","family":"Debus","given":"Jürgen","role":"aut"},{"role":"aut","given":"Sebastian","display":"Adeberg, Sebastian","family":"Adeberg"}],"title":[{"title_sort":"Clinical management of blood-brain barrier disruptions after active raster-scanned carbon ion re-radiotherapy in patients with recurrent head-and-neck cancer","title":"Clinical management of blood-brain barrier disruptions after active raster-scanned carbon ion re-radiotherapy in patients with recurrent head-and-neck cancer"}],"relHost":[{"part":{"text":"11(2019,3) Artikel-Nummer 383, 10 Seiten","issue":"3","volume":"11","extent":"10","year":"2019"},"title":[{"title_sort":"Cancers","title":"Cancers"}],"physDesc":[{"extent":"Online-Ressource"}],"type":{"bibl":"periodical","media":"Online-Ressource"},"id":{"eki":["614095670"],"zdb":["2527080-1"],"issn":["2072-6694"]},"language":["eng"],"origin":[{"dateIssuedKey":"2009","publisher":"MDPI","dateIssuedDisp":"2009-","publisherPlace":"Basel"}],"pubHistory":["1.2009 -"],"recId":"614095670","note":["Gesehen am 27.05.2020"],"name":{"displayForm":["Molecular Diversity Preservation International (MDPI)"]},"disp":"Clinical management of blood-brain barrier disruptions after active raster-scanned carbon ion re-radiotherapy in patients with recurrent head-and-neck cancerCancers"}],"origin":[{"dateIssuedKey":"2019","dateIssuedDisp":"19 March 2019"}],"id":{"eki":["1666436429"],"doi":["10.3390/cancers11030383"]},"type":{"media":"Online-Ressource","bibl":"article-journal"},"language":["eng"]} | ||
| SRT | |a HELDTHOMASCLINICALMA1920 | ||