EphB2-dependent signaling promotes neuronal excitotoxicity and inflammation in the acute phase of ischemic stroke
Local cerebral hypoperfusion causes ischemic stroke while driving multiple cell-specific responses including inflammation, glutamate-induced neurotoxicity mediated via NMDAR, edema formation and angiogenesis. Despite the relevance of these pathophysiological mechanisms for disease progression and ou...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
5 February 2019
|
| In: |
Acta Neuropathologica Communications
Year: 2019, Jahrgang: 7, Pages: 1-23 |
| ISSN: | 2051-5960 |
| DOI: | 10.1186/s40478-019-0669-7 |
| Online-Zugang: | Verlag, kostenfrei, Volltext: https://doi.org/10.1186/s40478-019-0669-7
|
| Verfasserangaben: | Anne-Sophie Ernst, Laura-Inés Böhler, Anna M. Hagenston, Angelika Hoffmann, Sabine Heiland, Carsten Sticht, Martin Bendszus, Markus Hecker, Hilmar Bading, Hugo H. Marti, Thomas Korff and Reiner Kunze |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1666437301 | ||
| 003 | DE-627 | ||
| 005 | 20230426220513.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 190528s2019 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1186/s40478-019-0669-7 |2 doi | |
| 035 | |a (DE-627)1666437301 | ||
| 035 | |a (DE-599)KXP1666437301 | ||
| 035 | |a (OCoLC)1264076226 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Ernst, Anne-Sophie |e VerfasserIn |0 (DE-588)1167521455 |0 (DE-627)1031152563 |0 (DE-576)511172729 |4 aut | |
| 245 | 1 | 0 | |a EphB2-dependent signaling promotes neuronal excitotoxicity and inflammation in the acute phase of ischemic stroke |c Anne-Sophie Ernst, Laura-Inés Böhler, Anna M. Hagenston, Angelika Hoffmann, Sabine Heiland, Carsten Sticht, Martin Bendszus, Markus Hecker, Hilmar Bading, Hugo H. Marti, Thomas Korff and Reiner Kunze |
| 264 | 1 | |c 5 February 2019 | |
| 300 | |a 23 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 28.05.2019 | ||
| 520 | |a Local cerebral hypoperfusion causes ischemic stroke while driving multiple cell-specific responses including inflammation, glutamate-induced neurotoxicity mediated via NMDAR, edema formation and angiogenesis. Despite the relevance of these pathophysiological mechanisms for disease progression and outcome, molecular determinants controlling the onset of these processes are only partially understood. In this context, our study intended to investigate the functional role of EphB2, a receptor tyrosine kinase that is crucial for synapse function and binds to membrane-associated ephrin-B ligands. | ||
| 700 | 1 | |a Böhler, Laura-Inés |e VerfasserIn |0 (DE-588)1125974303 |0 (DE-627)880574208 |0 (DE-576)483672602 |4 aut | |
| 700 | 1 | |a Hertle, Anna M. |e VerfasserIn |0 (DE-588)1033242705 |0 (DE-627)740374338 |0 (DE-576)38082504X |4 aut | |
| 700 | 1 | |a Hoffmann, Angelika |e VerfasserIn |0 (DE-588)1036902080 |0 (DE-627)751406759 |0 (DE-576)38950372X |4 aut | |
| 700 | 1 | |a Heiland, Sabine |e VerfasserIn |0 (DE-588)106732626X |0 (DE-627)818624450 |0 (DE-576)426561368 |4 aut | |
| 700 | 1 | |a Sticht, Carsten |d 1972- |e VerfasserIn |0 (DE-588)1020115718 |0 (DE-627)691110077 |0 (DE-576)250042177 |4 aut | |
| 700 | 1 | |a Bendszus, Martin |e VerfasserIn |0 (DE-588)1032676426 |0 (DE-627)738634131 |0 (DE-576)175567697 |4 aut | |
| 700 | 1 | |a Hecker, Markus |d 1960- |e VerfasserIn |0 (DE-588)1071693344 |0 (DE-627)826266037 |0 (DE-576)433260319 |4 aut | |
| 700 | 1 | |a Bading, Hilmar |d 1958- |e VerfasserIn |0 (DE-588)1017989680 |0 (DE-627)690486553 |0 (DE-576)170837947 |4 aut | |
| 700 | 1 | |a Marti, Hugo |e VerfasserIn |0 (DE-588)1137018356 |0 (DE-627)893957208 |0 (DE-576)491045468 |4 aut | |
| 700 | 1 | |a Korff, Thomas |e VerfasserIn |0 (DE-588)1048734951 |0 (DE-627)781211824 |0 (DE-576)386952604 |4 aut | |
| 700 | 1 | |a Kunze, Reiner |d 1980- |e VerfasserIn |0 (DE-588)141152494 |0 (DE-627)62540128X |0 (DE-576)321552504 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Acta Neuropathologica Communications |d London : Biomed Central, 2013 |g 7(2019), Artikel-ID 15, Seite 1-23 |h Online-Ressource |w (DE-627)746066465 |w (DE-600)2715589-4 |w (DE-576)382284372 |x 2051-5960 |7 nnas |a EphB2-dependent signaling promotes neuronal excitotoxicity and inflammation in the acute phase of ischemic stroke |
| 773 | 1 | 8 | |g volume:7 |g year:2019 |g elocationid:15 |g pages:1-23 |g extent:23 |a EphB2-dependent signaling promotes neuronal excitotoxicity and inflammation in the acute phase of ischemic stroke |
| 856 | 4 | 0 | |u https://doi.org/10.1186/s40478-019-0669-7 |x Verlag |x Resolving-System |z kostenfrei |3 Volltext |
| 856 | 4 | 0 | |u https://doi.org/10.1186/s40478-019-0669-7 |x Verlag |z kostenfrei |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20190528 | ||
| 993 | |a Article | ||
| 994 | |a 2019 | ||
| 998 | |g 141152494 |a Kunze, Reiner |m 141152494:Kunze, Reiner |d 50000 |d 53200 |e 50000PK141152494 |e 53200PK141152494 |k 0/50000/ |k 1/50000/53200/ |p 12 |y j | ||
| 998 | |g 1048734951 |a Korff, Thomas |m 1048734951:Korff, Thomas |d 50000 |d 53200 |e 50000PK1048734951 |e 53200PK1048734951 |k 0/50000/ |k 1/50000/53200/ |p 11 | ||
| 998 | |g 1137018356 |a Marti, Hugo |m 1137018356:Marti, Hugo |d 50000 |d 53200 |e 50000PM1137018356 |e 53200PM1137018356 |k 0/50000/ |k 1/50000/53200/ |p 10 | ||
| 998 | |g 1017989680 |a Bading, Hilmar |m 1017989680:Bading, Hilmar |d 700000 |d 712000 |d 712100 |e 700000PB1017989680 |e 712000PB1017989680 |e 712100PB1017989680 |k 0/700000/ |k 1/700000/712000/ |k 2/700000/712000/712100/ |p 9 | ||
| 998 | |g 1071693344 |a Hecker, Markus |m 1071693344:Hecker, Markus |d 50000 |d 53200 |e 50000PH1071693344 |e 53200PH1071693344 |k 0/50000/ |k 1/50000/53200/ |p 8 | ||
| 998 | |g 1032676426 |a Bendszus, Martin |m 1032676426:Bendszus, Martin |d 910000 |d 911100 |e 910000PB1032676426 |e 911100PB1032676426 |k 0/910000/ |k 1/910000/911100/ |p 7 | ||
| 998 | |g 1020115718 |a Sticht, Carsten |m 1020115718:Sticht, Carsten |d 60000 |d 999811 |e 60000PS1020115718 |e 999811PS1020115718 |k 0/60000/ |k 1/60000/999811/ |p 6 | ||
| 998 | |g 106732626X |a Heiland, Sabine |m 106732626X:Heiland, Sabine |d 910000 |d 911100 |e 910000PH106732626X |e 911100PH106732626X |k 0/910000/ |k 1/910000/911100/ |p 5 | ||
| 998 | |g 1036902080 |a Hoffmann, Angelika |m 1036902080:Hoffmann, Angelika |d 910000 |d 911100 |e 910000PH1036902080 |e 911100PH1036902080 |k 0/910000/ |k 1/910000/911100/ |p 4 | ||
| 998 | |g 1033242705 |a Hertle, Anna M. |m 1033242705:Hertle, Anna M. |d 700000 |d 712000 |d 712100 |e 700000PH1033242705 |e 712000PH1033242705 |e 712100PH1033242705 |k 0/700000/ |k 1/700000/712000/ |k 2/700000/712000/712100/ |p 3 | ||
| 998 | |g 1125974303 |a Böhler, Laura-Inés |m 1125974303:Böhler, Laura-Inés |d 50000 |d 53200 |e 50000PB1125974303 |e 53200PB1125974303 |k 0/50000/ |k 1/50000/53200/ |p 2 | ||
| 998 | |g 1167521455 |a Ernst, Anne-Sophie |m 1167521455:Ernst, Anne-Sophie |d 50000 |d 53200 |e 50000PE1167521455 |e 53200PE1167521455 |k 0/50000/ |k 1/50000/53200/ |p 1 |x j | ||
| 999 | |a KXP-PPN1666437301 |e 348002825X | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"recId":"1666437301","note":["Gesehen am 28.05.2019"],"name":{"displayForm":["Anne-Sophie Ernst, Laura-Inés Böhler, Anna M. Hagenston, Angelika Hoffmann, Sabine Heiland, Carsten Sticht, Martin Bendszus, Markus Hecker, Hilmar Bading, Hugo H. Marti, Thomas Korff and Reiner Kunze"]},"relHost":[{"note":["Gesehen am 29.11.18"],"pubHistory":["1.2013 -"],"recId":"746066465","disp":"EphB2-dependent signaling promotes neuronal excitotoxicity and inflammation in the acute phase of ischemic strokeActa Neuropathologica Communications","title":[{"title":"Acta Neuropathologica Communications","title_sort":"Acta Neuropathologica Communications"}],"physDesc":[{"extent":"Online-Ressource"}],"part":{"volume":"7","year":"2019","extent":"23","pages":"1-23","text":"7(2019), Artikel-ID 15, Seite 1-23"},"language":["eng"],"id":{"zdb":["2715589-4"],"issn":["2051-5960"],"eki":["746066465"]},"type":{"media":"Online-Ressource","bibl":"periodical"},"origin":[{"publisherPlace":"London","dateIssuedDisp":"2013-","dateIssuedKey":"2013","publisher":"Biomed Central"}]}],"person":[{"given":"Anne-Sophie","family":"Ernst","display":"Ernst, Anne-Sophie","role":"aut"},{"role":"aut","given":"Laura-Inés","family":"Böhler","display":"Böhler, Laura-Inés"},{"display":"Hertle, Anna M.","family":"Hertle","given":"Anna M.","role":"aut"},{"family":"Hoffmann","display":"Hoffmann, Angelika","given":"Angelika","role":"aut"},{"role":"aut","given":"Sabine","family":"Heiland","display":"Heiland, Sabine"},{"role":"aut","given":"Carsten","display":"Sticht, Carsten","family":"Sticht"},{"given":"Martin","display":"Bendszus, Martin","family":"Bendszus","role":"aut"},{"family":"Hecker","display":"Hecker, Markus","given":"Markus","role":"aut"},{"given":"Hilmar","display":"Bading, Hilmar","family":"Bading","role":"aut"},{"display":"Marti, Hugo","family":"Marti","given":"Hugo","role":"aut"},{"display":"Korff, Thomas","family":"Korff","given":"Thomas","role":"aut"},{"role":"aut","given":"Reiner","family":"Kunze","display":"Kunze, Reiner"}],"title":[{"title_sort":"EphB2-dependent signaling promotes neuronal excitotoxicity and inflammation in the acute phase of ischemic stroke","title":"EphB2-dependent signaling promotes neuronal excitotoxicity and inflammation in the acute phase of ischemic stroke"}],"physDesc":[{"extent":"23 S."}],"origin":[{"dateIssuedDisp":"5 February 2019","dateIssuedKey":"2019"}],"id":{"doi":["10.1186/s40478-019-0669-7"],"eki":["1666437301"]},"language":["eng"],"type":{"bibl":"article-journal","media":"Online-Ressource"}} | ||
| SRT | |a ERNSTANNESEPHB2DEPEN5201 | ||