Grey matter volume differences associated with extremely low levels of cannabis use in adolescence
Rates of cannabis use among adolescents are high, and are increasing concurrent with changes in the legal status of marijuana and societal attitudes regarding its use. Recreational cannabis use is understudied, especially in the adolescent period when neural maturation may make users particularly vu...
Gespeichert in:
| Hauptverfasser: | , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
2019
|
| In: |
The journal of neuroscience
Year: 2019, Jahrgang: 39, Heft: 10, Pages: 1817-1827 |
| ISSN: | 1529-2401 |
| DOI: | 10.1523/JNEUROSCI.3375-17.2018 |
| Online-Zugang: | Verlag, Volltext: https://doi.org/10.1523/JNEUROSCI.3375-17.2018 Verlag, Volltext: http://www.jneurosci.org/content/39/10/1817 
|
| Verfasserangaben: | Catherine Orr, Philip Spechler, Zhipeng Cao, Matthew Albaugh, Bader Chaarani, Scott Mackey, Deepak D'Souza, Nicholas Allgaier, Tobias Banaschewski, Arun L. W. Bokde, Uli Bromberg, Christian Büchel, Erin Burke Quinlan, Patricia Conrod, Sylvane Desrivières, Herta Flor, Vincent Frouin, Penny Gowland, Andreas Heinz, Bernd Ittermann, Jean-Luc Martinot, Marie-Laure Paillère Martinot, Frauke Nees, Dimitri Papadopoulos Orfanos, Tomáš Paus, Luise Poustka, Sabina Millenet, Juliane H. Fröhner, Rajiv Radhakrishnan, Michael N. Smolka, Henrik Walter, Robert Whelan, Gunter Schumann, Alexandra Potter, and Hugh Garavan |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1666478105 | ||
| 003 | DE-627 | ||
| 005 | 20220816162740.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 190529s2019 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1523/JNEUROSCI.3375-17.2018 |2 doi | |
| 035 | |a (DE-627)1666478105 | ||
| 035 | |a (DE-599)KXP1666478105 | ||
| 035 | |a (OCoLC)1341225812 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Orr, Catherine |e VerfasserIn |0 (DE-588)1187356468 |0 (DE-627)1666478393 |4 aut | |
| 245 | 1 | 0 | |a Grey matter volume differences associated with extremely low levels of cannabis use in adolescence |c Catherine Orr, Philip Spechler, Zhipeng Cao, Matthew Albaugh, Bader Chaarani, Scott Mackey, Deepak D'Souza, Nicholas Allgaier, Tobias Banaschewski, Arun L. W. Bokde, Uli Bromberg, Christian Büchel, Erin Burke Quinlan, Patricia Conrod, Sylvane Desrivières, Herta Flor, Vincent Frouin, Penny Gowland, Andreas Heinz, Bernd Ittermann, Jean-Luc Martinot, Marie-Laure Paillère Martinot, Frauke Nees, Dimitri Papadopoulos Orfanos, Tomáš Paus, Luise Poustka, Sabina Millenet, Juliane H. Fröhner, Rajiv Radhakrishnan, Michael N. Smolka, Henrik Walter, Robert Whelan, Gunter Schumann, Alexandra Potter, and Hugh Garavan |
| 264 | 1 | |c 2019 | |
| 300 | |a 11 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 29.05.2019 | ||
| 520 | |a Rates of cannabis use among adolescents are high, and are increasing concurrent with changes in the legal status of marijuana and societal attitudes regarding its use. Recreational cannabis use is understudied, especially in the adolescent period when neural maturation may make users particularly vulnerable to the effects of Δ-9-tetrahydrocannabinol (THC) on brain structure. In the current study, we used voxel-based morphometry to compare gray matter volume (GMV) in forty-six 14-year-old human adolescents (males and females) with just one or two instances of cannabis use and carefully matched THC-naive controls. We identified extensive regions in the bilateral medial temporal lobes as well as the bilateral posterior cingulate, lingual gyri, and cerebellum that showed greater GMV in the cannabis users. Analysis of longitudinal data confirmed that GMV differences were unlikely to precede cannabis use. GMV in the temporal regions was associated with contemporaneous performance on the Perceptual Reasoning Index and with future generalized anxiety symptoms in the cannabis users. The distribution of GMV effects mapped onto biomarkers of the endogenous cannabinoid system providing insight into possible mechanisms for these effects. - SIGNIFICANCE STATEMENT Almost 35% of American 10th graders have reported using cannabis and existing research suggests that initiation of cannabis use in adolescence is associated with long-term neurocognitive effects. We understand very little about the earliest effects of cannabis use, however, because most research is conducted in adults with a heavy pattern of lifetime use. This study presents evidence suggesting structural brain and cognitive effects of just one or two instances of cannabis use in adolescence. Converging evidence suggests a role for the endocannabinoid system in these effects. This research is particularly timely as the legal status of cannabis is changing in many jurisdictions and the perceived risk by youth associated with smoking cannabis has declined in recent years. | ||
| 650 | 4 | |a adolescent substance use | |
| 650 | 4 | |a cannabis | |
| 650 | 4 | |a cognition | |
| 650 | 4 | |a marijuana | |
| 650 | 4 | |a psychopathology | |
| 650 | 4 | |a voxel-based morphometry | |
| 700 | 1 | |a Flor, Herta |d 1954- |e VerfasserIn |0 (DE-588)110841816 |0 (DE-627)636273695 |0 (DE-576)160967732 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t The journal of neuroscience |d Washington, DC : Soc., 1981 |g 39(2019), 10, Seite 1817-1827 |h Online-Ressource |w (DE-627)269536906 |w (DE-600)1475274-8 |w (DE-576)078590124 |x 1529-2401 |7 nnas |a Grey matter volume differences associated with extremely low levels of cannabis use in adolescence |
| 773 | 1 | 8 | |g volume:39 |g year:2019 |g number:10 |g pages:1817-1827 |g extent:11 |a Grey matter volume differences associated with extremely low levels of cannabis use in adolescence |
| 856 | 4 | 0 | |u https://doi.org/10.1523/JNEUROSCI.3375-17.2018 |x Verlag |x Resolving-System |3 Volltext |
| 856 | 4 | 0 | |u http://www.jneurosci.org/content/39/10/1817 |x Verlag |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20190529 | ||
| 993 | |a Article | ||
| 994 | |a 2019 | ||
| 998 | |g 110841816 |a Flor, Herta |m 110841816:Flor, Herta |d 60000 |e 60000PF110841816 |k 0/60000/ |p 16 | ||
| 999 | |a KXP-PPN1666478105 |e 3480073271 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"physDesc":[{"extent":"11 S."}],"name":{"displayForm":["Catherine Orr, Philip Spechler, Zhipeng Cao, Matthew Albaugh, Bader Chaarani, Scott Mackey, Deepak D'Souza, Nicholas Allgaier, Tobias Banaschewski, Arun L. W. Bokde, Uli Bromberg, Christian Büchel, Erin Burke Quinlan, Patricia Conrod, Sylvane Desrivières, Herta Flor, Vincent Frouin, Penny Gowland, Andreas Heinz, Bernd Ittermann, Jean-Luc Martinot, Marie-Laure Paillère Martinot, Frauke Nees, Dimitri Papadopoulos Orfanos, Tomáš Paus, Luise Poustka, Sabina Millenet, Juliane H. Fröhner, Rajiv Radhakrishnan, Michael N. Smolka, Henrik Walter, Robert Whelan, Gunter Schumann, Alexandra Potter, and Hugh Garavan"]},"relHost":[{"part":{"pages":"1817-1827","year":"2019","issue":"10","text":"39(2019), 10, Seite 1817-1827","volume":"39","extent":"11"},"titleAlt":[{"title":"Neuroscience"},{"title":"JNeurosci"}],"language":["eng"],"corporate":[{"display":"Society for Neuroscience","role":"isb"}],"id":{"eki":["269536906"],"issn":["1529-2401"],"zdb":["1475274-8"]},"recId":"269536906","physDesc":[{"extent":"Online-Ressource"}],"type":{"media":"Online-Ressource","bibl":"periodical"},"disp":"Grey matter volume differences associated with extremely low levels of cannabis use in adolescenceThe journal of neuroscience","title":[{"subtitle":"the official journal of the Society for Neuroscience","title_sort":"journal of neuroscience","title":"The journal of neuroscience"}],"note":["Fortsetzung der Druck-Ausgabe","Gesehen am 07.11.2022"],"pubHistory":["1.1981 -"],"origin":[{"publisherPlace":"Washington, DC","dateIssuedDisp":"1981-","publisher":"Soc.","dateIssuedKey":"1981"}]}],"recId":"1666478105","id":{"eki":["1666478105"],"doi":["10.1523/JNEUROSCI.3375-17.2018"]},"title":[{"title_sort":"Grey matter volume differences associated with extremely low levels of cannabis use in adolescence","title":"Grey matter volume differences associated with extremely low levels of cannabis use in adolescence"}],"note":["Gesehen am 29.05.2019"],"origin":[{"dateIssuedKey":"2019","dateIssuedDisp":"2019"}],"type":{"bibl":"article-journal","media":"Online-Ressource"},"language":["eng"],"person":[{"display":"Orr, Catherine","family":"Orr","given":"Catherine","role":"aut"},{"given":"Herta","role":"aut","display":"Flor, Herta","family":"Flor"}]} | ||
| SRT | |a ORRCATHERIGREYMATTER2019 | ||