Non-invasive metastasis prognosis from plasma metabolites in stage II colorectal cancer patients: the DACHS study
Metastasis is the main cause of death from colorectal cancer (CRC). About 20% of stage II CRC patients develop metastasis during the course of disease. We performed metabolic profiling of plasma samples from non-metastasized and metachronously metastasized stage II CRC patients to assess the potenti...
Gespeichert in:
| Hauptverfasser: | , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
2019
|
| In: |
International journal of cancer
Year: 2018, Jahrgang: 145, Heft: 1, Pages: 221-231 |
| ISSN: | 1097-0215 |
| DOI: | 10.1002/ijc.32076 |
| Online-Zugang: | Verlag, Pay-per-use, Volltext: https://doi.org/10.1002/ijc.32076 Verlag, Pay-per-use, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/ijc.32076 
|
| Verfasserangaben: | Inna Zaimenko, Carsten Jaeger, Hermann Brenner, Jenny Chang‐Claude, Michael Hoffmeister, Carsten Grötzinger, Katharina Detjen, Susen Burock, Clemens A. Schmitt, Ulrike Stein and Jan Lisec |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1666577170 | ||
| 003 | DE-627 | ||
| 005 | 20230426220644.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 190531r20192018xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1002/ijc.32076 |2 doi | |
| 035 | |a (DE-627)1666577170 | ||
| 035 | |a (DE-599)KXP1666577170 | ||
| 035 | |a (OCoLC)1341225720 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Zaimenko, Inna |e VerfasserIn |0 (DE-588)1155736842 |0 (DE-627)1017941424 |0 (DE-576)501819894 |4 aut | |
| 245 | 1 | 0 | |a Non-invasive metastasis prognosis from plasma metabolites in stage II colorectal cancer patients |b the DACHS study |c Inna Zaimenko, Carsten Jaeger, Hermann Brenner, Jenny Chang‐Claude, Michael Hoffmeister, Carsten Grötzinger, Katharina Detjen, Susen Burock, Clemens A. Schmitt, Ulrike Stein and Jan Lisec |
| 264 | 1 | |c 2019 | |
| 300 | |a 11 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 31.05.2019 | ||
| 500 | |a First published: 18 December 2018 | ||
| 520 | |a Metastasis is the main cause of death from colorectal cancer (CRC). About 20% of stage II CRC patients develop metastasis during the course of disease. We performed metabolic profiling of plasma samples from non-metastasized and metachronously metastasized stage II CRC patients to assess the potential of plasma metabolites to serve as biomarkers for stratification of stage II CRC patients according to metastasis risk. We compared the metabolic profiles of plasma samples prospectively obtained prior to metastasis formation from non-metastasized vs. metachronously metastasized stage II CRC patients of the German population-based case-control multicenter DACHS study retrospectively. Plasma samples were analyzed from stage II CRC patients for whom follow-up data including the information on metachronous metastasis were available. To identify metabolites distinguishing non-metastasized from metachronously metastasized stage II CRC patients robust supervised classifications using decision trees and support vector machines were performed and verified by 10-fold cross-validation, by nested cross-validation and by traditional validation using training and test sets. We found that metabolic profiles distinguish non-metastasized from metachronously metastasized stage II CRC patients. Classification models from decision trees and support vector machines with 10-fold cross-validation gave average accuracy of 0.75 (sensitivity 0.79, specificity 0.7) and 0.82 (sensitivity 0.85, specificity 0.77), respectively, correctly predicting metachronous metastasis in stage II CRC patients. Taken together, plasma metabolic profiles distinguished non-metastasized and metachronously metastasized stage II CRC patients. The classification models consisting of few metabolites stratify non-invasively stage II CRC patients according to their risk for metachronous metastasis. | ||
| 534 | |c 2018 | ||
| 650 | 4 | |a colorectal cancer | |
| 650 | 4 | |a metabolomics | |
| 650 | 4 | |a metastasis prognosis | |
| 650 | 4 | |a plasma | |
| 650 | 4 | |a stage II patients | |
| 700 | 1 | |a Brenner, Hermann |e VerfasserIn |0 (DE-588)1020516445 |0 (DE-627)691247005 |0 (DE-576)360642136 |4 aut | |
| 700 | 1 | |a Chang-Claude, Jenny |e VerfasserIn |0 (DE-588)1049304993 |0 (DE-627)781626188 |0 (DE-576)168344475 |4 aut | |
| 700 | 1 | |a Hoffmeister, Michael |d 1973- |e VerfasserIn |0 (DE-588)134103726 |0 (DE-627)560880820 |0 (DE-576)277089565 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t International journal of cancer |d Bognor Regis : Wiley-Liss, 1966 |g 145(2019), 1, Seite 221-231 |h Online-Ressource |w (DE-627)269532781 |w (DE-600)1474822-8 |w (DE-576)079876129 |x 1097-0215 |7 nnas |a Non-invasive metastasis prognosis from plasma metabolites in stage II colorectal cancer patients the DACHS study |
| 773 | 1 | 8 | |g volume:145 |g year:2019 |g number:1 |g pages:221-231 |g extent:11 |a Non-invasive metastasis prognosis from plasma metabolites in stage II colorectal cancer patients the DACHS study |
| 856 | 4 | 0 | |u https://doi.org/10.1002/ijc.32076 |x Verlag |x Resolving-System |z Pay-per-use |3 Volltext |
| 856 | 4 | 0 | |u https://onlinelibrary.wiley.com/doi/abs/10.1002/ijc.32076 |x Verlag |z Pay-per-use |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20190531 | ||
| 993 | |a Article | ||
| 994 | |a 2019 | ||
| 998 | |g 134103726 |a Hoffmeister, Michael |m 134103726:Hoffmeister, Michael |d 50000 |e 50000PH134103726 |k 0/50000/ |p 5 | ||
| 998 | |g 1049304993 |a Chang-Claude, Jenny |m 1049304993:Chang-Claude, Jenny |d 50000 |e 50000PC1049304993 |k 0/50000/ |p 4 | ||
| 998 | |g 1020516445 |a Brenner, Hermann |m 1020516445:Brenner, Hermann |d 850000 |d 851600 |d 50000 |e 850000PB1020516445 |e 851600PB1020516445 |e 50000PB1020516445 |k 0/850000/ |k 1/850000/851600/ |k 0/50000/ |p 3 | ||
| 999 | |a KXP-PPN1666577170 |e 3480415229 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"person":[{"given":"Inna","display":"Zaimenko, Inna","family":"Zaimenko","role":"aut"},{"role":"aut","family":"Brenner","display":"Brenner, Hermann","given":"Hermann"},{"given":"Jenny","display":"Chang-Claude, Jenny","family":"Chang-Claude","role":"aut"},{"role":"aut","family":"Hoffmeister","display":"Hoffmeister, Michael","given":"Michael"}],"type":{"media":"Online-Ressource","bibl":"article-journal"},"relHost":[{"corporate":[{"role":"isb","display":"International Union against Cancer"}],"pubHistory":["1.1966 -"],"part":{"pages":"221-231","volume":"145","text":"145(2019), 1, Seite 221-231","issue":"1","extent":"11","year":"2019"},"disp":"Non-invasive metastasis prognosis from plasma metabolites in stage II colorectal cancer patients the DACHS studyInternational journal of cancer","recId":"269532781","type":{"media":"Online-Ressource","bibl":"periodical"},"titleAlt":[{"title":"Predictive oncology"}],"titleTranslated":[{"translated":"Journal international du cancer"}],"physDesc":[{"extent":"Online-Ressource"}],"language":["eng"],"title":[{"subtitle":"publication of the International Union against Cancer (UICC) = Journal international du cancer","title":"International journal of cancer","title_sort":"International journal of cancer"}],"note":["Gesehen am 28.02.08","Darin: Predictive oncology"],"id":{"doi":["10.1002/(ISSN)1097-0215"],"issn":["1097-0215"],"zdb":["1474822-8"],"eki":["269532781"]},"origin":[{"dateIssuedKey":"1966","publisherPlace":"Bognor Regis","dateIssuedDisp":"1966-","publisher":"Wiley-Liss"}]}],"origin":[{"dateIssuedDisp":"2019","dateIssuedKey":"2019"}],"id":{"eki":["1666577170"],"doi":["10.1002/ijc.32076"]},"recId":"1666577170","physDesc":[{"extent":"11 S."}],"title":[{"title":"Non-invasive metastasis prognosis from plasma metabolites in stage II colorectal cancer patients","subtitle":"the DACHS study","title_sort":"Non-invasive metastasis prognosis from plasma metabolites in stage II colorectal cancer patients"}],"language":["eng"],"note":["Gesehen am 31.05.2019","First published: 18 December 2018"],"name":{"displayForm":["Inna Zaimenko, Carsten Jaeger, Hermann Brenner, Jenny Chang‐Claude, Michael Hoffmeister, Carsten Grötzinger, Katharina Detjen, Susen Burock, Clemens A. Schmitt, Ulrike Stein and Jan Lisec"]}} | ||
| SRT | |a ZAIMENKOINNONINVASIV2019 | ||