Buchumschlag

Pre-diagnostic derivatives of reactive oxygen metabolites and the occurrence of lung, colorectal, breast and prostate cancer: an individual participant data meta-analysis of two large population-based studies

Oxidative stress may be involved in carcinogenesis and biomarkers of oxidative stress like derivatives of reactive oxygen metabolites (d-ROM) may be useful for cancer prediction. However, no previous study assessed the association of pre-diagnostic d-ROM measurements with cancer incidence. We measur...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Gao, Xin (VerfasserIn) , Xuan, Yang (VerfasserIn) , Anusruti, Ankita (VerfasserIn) , Brenner, Hermann (VerfasserIn) , Schöttker, Ben (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 2019
In: International journal of cancer
Year: 2018, Jahrgang: 145, Heft: 1, Pages: 49-57
ISSN:1097-0215
DOI:10.1002/ijc.32073
Online-Zugang:Verlag, Pay-per-use, Volltext: https://doi.org/10.1002/ijc.32073
Verlag, Pay-per-use, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/ijc.32073
Volltext
Verfasserangaben:Xīn Gào, Tom Wilsgaard, Eugène HJM Jansen, Bernd Holleczek, Yan Zhang, Yang Xuan, Ankita Anusruti, Hermann Brenner and Ben Schöttker
Beschreibung
Zusammenfassung:Oxidative stress may be involved in carcinogenesis and biomarkers of oxidative stress like derivatives of reactive oxygen metabolites (d-ROM) may be useful for cancer prediction. However, no previous study assessed the association of pre-diagnostic d-ROM measurements with cancer incidence. We measured serum d-ROM levels in a cohort sample of n = 4,345 participants of the German ESTHER study and in a case-cohort sample of the Norwegian Tromsø study (cancer cases: n = 941; subcohort: n = 1,000). Moreover, d-ROM was repeatedly measured at follow-ups of both studies. Hazard ratios (HRs) and 95% confidence intervals (95% CIs) were derived by (weighted) multivariable-adjusted Cox regression with time-dependent modeling of d-ROM levels for incident lung, colorectal, breast and prostate cancer. Individual study results were pooled by random effects meta-analysis. The HRs (95% CI) for comparison of top and bottom d-ROM tertile were statistically significant for lung (1.90 [1.25-2.89]), colorectal (1.70 [1.15-2.51]) and breast cancer incidence (1.45 [1.01-2.09]) but not for prostate cancer incidence (1.20 [0.84-1.72]). In conclusion, this individual participant data meta-analysis of two large population-based cohort studies with repeated d-ROM measurements yielded evidence for an involvement of high oxidative stress in carcinogenesis. Given the observed associations of pre-diagnostic d-ROM measurements with lung, colorectal and breast cancer incidence, subjects with increased serum d-ROM levels should be recommended to reduce these levels by lifestyle changes including smoking cessation, a healthy diet and an increase in physical activity.
Beschreibung:Gesehen am 31.05.2019
First published: 18 December 2018
Beschreibung:Online Resource
ISSN:1097-0215
DOI:10.1002/ijc.32073

Ähnliche Einträge