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Investigation on potential associations of oxidatively generated DNA/RNA damage with lung, colorectal, breast, prostate and total cancer incidence

Oxidative stress has been linked to cancer development in previous studies. However, the association between pre-diagnostic oxidatively generated DNA/RNA damage levels and incident cancer has rarely been investigated. Urinary oxidized guanine/guanosine (OxGua) concentrations, including 8-hydroxy-2′-...

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Hauptverfasser: Gao, Xin (VerfasserIn) , Holleczek, Bernd (VerfasserIn) , Cuk, Katarina (VerfasserIn) , Zhang, Yan (VerfasserIn) , Anusruti, Ankita (VerfasserIn) , Xuan, Yang (VerfasserIn) , Brenner, Hermann (VerfasserIn) , Schöttker, Ben (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 08 May 2019
In: Scientific reports
Year: 2019, Jahrgang: 9
ISSN:2045-2322
DOI:10.1038/s41598-019-42596-x
Online-Zugang:Verlag, Volltext: https://doi.org/10.1038/s41598-019-42596-x
Verlag, Volltext: https://www.nature.com/articles/s41598-019-42596-x
Volltext
Verfasserangaben:Xīn Gào, Bernd Holleczek, Katarina Cuk, Yan Zhang, Ankita Anusruti, Yang Xuan, Yiwei Xu, Hermann Brenner & Ben Schöttker
Beschreibung
Zusammenfassung:Oxidative stress has been linked to cancer development in previous studies. However, the association between pre-diagnostic oxidatively generated DNA/RNA damage levels and incident cancer has rarely been investigated. Urinary oxidized guanine/guanosine (OxGua) concentrations, including 8-hydroxy-2′-deoxyguanosine, were assessed in 8,793 older adults in a population-based German cohort. 1,540 incident cancer cases, including 207 lung, 196 colorectal, 218 breast and 245 prostate cancer cases were diagnosed during over 14 years of follow-up. Associations of OxGua levels with cancer outcomes were not observed in the total population in multi-variable adjusted Cox regression models. However, in subgroup analyses, colorectal cancer incidence increased by 8%, 9% and 8% with one standard deviation increase in OxGua levels among current non-smokers, female and non-obese participants, respectively. Additionally, among non-smokers, overall and prostate cancer incidences statistically significantly increased by 5% and 13% per 1 standard deviation increase in OxGua levels, respectively. In contrast, OxGua levels were inversely associated with the risk of prostate cancer among current smokers. However, none of the subgroup analyses had p-values below a threshold for statistical significance after correction for multiple testing. Thus, results need to be validated in further studies. There might be a pattern that oxidatively generated DNA/RNA damage is a weak cancer risk factor in the absence of other strong risk factors, such as smoking, obesity and male sex.
Beschreibung:Gesehen am 05.06.2019
Beschreibung:Online Resource
ISSN:2045-2322
DOI:10.1038/s41598-019-42596-x

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