IL6 shapes an inflammatory microenvironment and triggers the development of unique types of cancer in end-stage kidney
BACKGROUND/AIM: Chronic inflammation in end-stage kidney is associated with the development of pre-neoplastic lesions and renal cell tumors. The aim of this study was to clarify the role of the inflammatory microenvironment in this process. - MATERIALS AND METHODS: We used representative microscopic...
Gespeichert in:
| Hauptverfasser: | , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
2019
|
| In: |
Anticancer research
Year: 2019, Jahrgang: 39, Heft: 4, Pages: 1869-1874 |
| ISSN: | 1791-7530 |
| DOI: | 10.21873/anticanres.13294 |
| Online-Zugang: | Verlag, Volltext: http://dx.doi.org/10.21873/anticanres.13294
|
| Verfasserangaben: | Lehel Peterfi, Maria V. Yusenko, Gyula Kovacs |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1666940267 | ||
| 003 | DE-627 | ||
| 005 | 20230426071819.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 190606s2019 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.21873/anticanres.13294 |2 doi | |
| 035 | |a (DE-627)1666940267 | ||
| 035 | |a (DE-599)KXP1666940267 | ||
| 035 | |a (OCoLC)1341227660 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Peterfi, Lehel |e VerfasserIn |0 (DE-588)1187980692 |0 (DE-627)1666944742 |4 aut | |
| 245 | 1 | 0 | |a IL6 shapes an inflammatory microenvironment and triggers the development of unique types of cancer in end-stage kidney |c Lehel Peterfi, Maria V. Yusenko, Gyula Kovacs |
| 264 | 1 | |c 2019 | |
| 300 | |a 6 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 06.06.2019 | ||
| 520 | |a BACKGROUND/AIM: Chronic inflammation in end-stage kidney is associated with the development of pre-neoplastic lesions and renal cell tumors. The aim of this study was to clarify the role of the inflammatory microenvironment in this process. - MATERIALS AND METHODS: We used representative microscopic slides from 11 end stage-kidneys containing pre-neoplastic lesions and tumors and applied immunohistochemistry to detect IL-6, SAA1 and LBP expression. We also applied array-based comparative genomic hybridization (CGH) analysis to detect genomic changes in tumor cells. - RESULTS: We identified strong expression of IL6, LBP and SAA1 in activated stromal fibroblasts, in proliferating epithelial and tumor cells. Array CGH detected unusual genomic changes in tumor cells. - CONCLUSION: Our data indicate that expression of IL6, acute phase protein SAA1 and LBP maintain a long-lasting inflammatory microenvironment that leads to remodeling of end-stage kidneys and the development of unique types of renal cell tumors. | ||
| 650 | 4 | |a Acute-Phase Proteins | |
| 650 | 4 | |a Adult | |
| 650 | 4 | |a Aged | |
| 650 | 4 | |a Carrier Proteins | |
| 650 | 4 | |a Cell Proliferation | |
| 650 | 4 | |a Comparative Genomic Hybridization | |
| 650 | 4 | |a End stage renal disease | |
| 650 | 4 | |a Epithelial Cells | |
| 650 | 4 | |a Female | |
| 650 | 4 | |a Fibroblasts | |
| 650 | 4 | |a Humans | |
| 650 | 4 | |a IL6 | |
| 650 | 4 | |a Immunohistochemistry | |
| 650 | 4 | |a Inflammation Mediators | |
| 650 | 4 | |a Interleukin-6 | |
| 650 | 4 | |a Kidney | |
| 650 | 4 | |a Kidney Failure, Chronic | |
| 650 | 4 | |a Kidney Neoplasms | |
| 650 | 4 | |a LBP | |
| 650 | 4 | |a Male | |
| 650 | 4 | |a Membrane Glycoproteins | |
| 650 | 4 | |a microenvironment | |
| 650 | 4 | |a Middle Aged | |
| 650 | 4 | |a Precancerous Conditions | |
| 650 | 4 | |a SAA1 | |
| 650 | 4 | |a Serum Amyloid A Protein | |
| 650 | 4 | |a Stromal Cells | |
| 650 | 4 | |a tumor development | |
| 650 | 4 | |a Tumor Microenvironment | |
| 700 | 1 | |a Yusenko, Maria |d 1981- |e VerfasserIn |0 (DE-588)139614990 |0 (DE-627)703398830 |0 (DE-576)312461313 |4 aut | |
| 700 | 1 | |a Kovacs, Gyula |e VerfasserIn |0 (DE-588)1081747579 |0 (DE-627)846587424 |0 (DE-576)454756399 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Anticancer research |d Kapandriti, Attiki, Greece : International Institute of Anticancer Research, 2004 |g 39(2019), 4, Seite 1869-1874 |h Online-Ressource |w (DE-627)387478493 |w (DE-600)2145376-7 |w (DE-576)358408717 |x 1791-7530 |7 nnas |a IL6 shapes an inflammatory microenvironment and triggers the development of unique types of cancer in end-stage kidney |
| 773 | 1 | 8 | |g volume:39 |g year:2019 |g number:4 |g pages:1869-1874 |g extent:6 |a IL6 shapes an inflammatory microenvironment and triggers the development of unique types of cancer in end-stage kidney |
| 856 | 4 | 0 | |u http://dx.doi.org/10.21873/anticanres.13294 |x Verlag |x Resolving-System |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20190606 | ||
| 993 | |a Article | ||
| 994 | |a 2019 | ||
| 998 | |g 1081747579 |a Kovacs, Gyula |m 1081747579:Kovacs, Gyula |d 50000 |e 50000PK1081747579 |k 0/50000/ |p 3 |y j | ||
| 998 | |g 139614990 |a Yusenko, Maria |m 139614990:Yusenko, Maria |p 2 | ||
| 999 | |a KXP-PPN1666940267 |e 3481863667 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"relHost":[{"physDesc":[{"extent":"Online-Ressource"}],"id":{"eki":["387478493"],"zdb":["2145376-7"],"issn":["1791-7530"]},"origin":[{"publisher":"International Institute of Anticancer Research","dateIssuedKey":"2004","dateIssuedDisp":"2004-","publisherPlace":"Kapandriti, Attiki, Greece"}],"name":{"displayForm":["International Institute of Anticancer Research"]},"part":{"pages":"1869-1874","issue":"4","year":"2019","extent":"6","volume":"39","text":"39(2019), 4, Seite 1869-1874"},"pubHistory":["Nachgewiesen 24.2004 -"],"language":["eng"],"recId":"387478493","type":{"media":"Online-Ressource","bibl":"periodical"},"disp":"IL6 shapes an inflammatory microenvironment and triggers the development of unique types of cancer in end-stage kidneyAnticancer research","note":["Gesehen am 26.02.13"],"title":[{"title_sort":"Anticancer research","subtitle":"international journal of cancer research and treatment","title":"Anticancer research"}]}],"physDesc":[{"extent":"6 S."}],"id":{"eki":["1666940267"],"doi":["10.21873/anticanres.13294"]},"origin":[{"dateIssuedKey":"2019","dateIssuedDisp":"2019"}],"name":{"displayForm":["Lehel Peterfi, Maria V. Yusenko, Gyula Kovacs"]},"recId":"1666940267","language":["eng"],"note":["Gesehen am 06.06.2019"],"type":{"bibl":"article-journal","media":"Online-Ressource"},"title":[{"title":"IL6 shapes an inflammatory microenvironment and triggers the development of unique types of cancer in end-stage kidney","title_sort":"IL6 shapes an inflammatory microenvironment and triggers the development of unique types of cancer in end-stage kidney"}],"person":[{"given":"Lehel","family":"Peterfi","role":"aut","roleDisplay":"VerfasserIn","display":"Peterfi, Lehel"},{"given":"Maria","family":"Yusenko","role":"aut","display":"Yusenko, Maria","roleDisplay":"VerfasserIn"},{"roleDisplay":"VerfasserIn","display":"Kovacs, Gyula","role":"aut","family":"Kovacs","given":"Gyula"}]} | ||
| SRT | |a PETERFILEHIL6SHAPESA2019 | ||