Species-conserved reconfigurations of brain network topology induced by ketamine
Species-conserved (intermediate) phenotypes that can be quantified and compared across species offer important advantages for translational research and drug discovery. Here, we investigate the utility of network science methods to assess the pharmacological alterations of the large-scale architectu...
Gespeichert in:
| Hauptverfasser: | , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
19 April 2016
|
| In: |
Translational Psychiatry
Year: 2016, Jahrgang: 6, Heft: 4 |
| ISSN: | 2158-3188 |
| DOI: | 10.1038/tp.2016.53 |
| Online-Zugang: | Verlag, Volltext: https://doi.org/10.1038/tp.2016.53 Verlag, Volltext: https://www.nature.com/articles/tp201653 
|
| Verfasserangaben: | R. Becker, U. Braun, A.J. Schwarz, N. Gass, J.I. Schweiger, W. Weber-Fahr, E. Schenker, M. Spedding, C. Clemm von Hohenberg, C. Risterucci, Z. Zang, O. Grimm, H. Tost, A. Sartorius and A. Meyer-Lindenberg |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1667001353 | ||
| 003 | DE-627 | ||
| 005 | 20230426071825.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 190607s2016 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1038/tp.2016.53 |2 doi | |
| 035 | |a (DE-627)1667001353 | ||
| 035 | |a (DE-599)KXP1667001353 | ||
| 035 | |a (OCoLC)1341227654 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Becker, Robert |d 1984- |e VerfasserIn |0 (DE-588)1199416576 |0 (DE-627)1681728710 |4 aut | |
| 245 | 1 | 0 | |a Species-conserved reconfigurations of brain network topology induced by ketamine |c R. Becker, U. Braun, A.J. Schwarz, N. Gass, J.I. Schweiger, W. Weber-Fahr, E. Schenker, M. Spedding, C. Clemm von Hohenberg, C. Risterucci, Z. Zang, O. Grimm, H. Tost, A. Sartorius and A. Meyer-Lindenberg |
| 264 | 1 | |c 19 April 2016 | |
| 300 | |a 7 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 07.06.2019 | ||
| 520 | |a Species-conserved (intermediate) phenotypes that can be quantified and compared across species offer important advantages for translational research and drug discovery. Here, we investigate the utility of network science methods to assess the pharmacological alterations of the large-scale architecture of brain networks in rats and humans. In a double-blind, placebo-controlled, cross-over study in humans and a placebo-controlled two-group study in rats, we demonstrate that the application of ketamine leads to a topological reconfiguration of large-scale brain networks towards less-integrated and more-segregated information processing in both the species. As these alterations are opposed to those commonly observed in patients suffering from depression, they might indicate systems-level correlates of the antidepressant effect of ketamine. | ||
| 700 | 1 | |a Sartorius, Alexander |d 1966- |e VerfasserIn |0 (DE-588)1028604793 |0 (DE-627)732049350 |0 (DE-576)376099836 |4 aut | |
| 700 | 1 | |a Meyer-Lindenberg, Andreas |d 1965- |e VerfasserIn |0 (DE-588)1029137390 |0 (DE-627)732483069 |0 (DE-576)376589876 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Translational Psychiatry |d London : Nature Publishing Group, 2011 |g 6(2016,4) Artikel-Nummer e786, 7 Seiten |h Online-Ressource |w (DE-627)660807378 |w (DE-600)2609311-X |w (DE-576)345003462 |x 2158-3188 |7 nnas |a Species-conserved reconfigurations of brain network topology induced by ketamine |
| 773 | 1 | 8 | |g volume:6 |g year:2016 |g number:4 |g extent:7 |a Species-conserved reconfigurations of brain network topology induced by ketamine |
| 856 | 4 | 0 | |u https://doi.org/10.1038/tp.2016.53 |x Verlag |x Resolving-System |3 Volltext |
| 856 | 4 | 0 | |u https://www.nature.com/articles/tp201653 |x Verlag |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20190607 | ||
| 993 | |a Article | ||
| 994 | |a 2016 | ||
| 998 | |g 1029137390 |a Meyer-Lindenberg, Andreas |m 1029137390:Meyer-Lindenberg, Andreas |d 60000 |e 60000PM1029137390 |k 0/60000/ |p 15 |y j | ||
| 998 | |g 1028604793 |a Sartorius, Alexander |m 1028604793:Sartorius, Alexander |d 60000 |e 60000PS1028604793 |k 0/60000/ |p 14 | ||
| 998 | |g 1199416576 |a Becker, Robert |m 1199416576:Becker, Robert |d 60000 |e 60000PB1199416576 |k 0/60000/ | ||
| 999 | |a KXP-PPN1667001353 |e 3482015678 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"id":{"doi":["10.1038/tp.2016.53"],"eki":["1667001353"]},"origin":[{"dateIssuedKey":"2016","dateIssuedDisp":"19 April 2016"}],"title":[{"title_sort":"Species-conserved reconfigurations of brain network topology induced by ketamine","title":"Species-conserved reconfigurations of brain network topology induced by ketamine"}],"person":[{"display":"Becker, Robert","given":"Robert","role":"aut","family":"Becker"},{"role":"aut","given":"Alexander","family":"Sartorius","display":"Sartorius, Alexander"},{"family":"Meyer-Lindenberg","given":"Andreas","role":"aut","display":"Meyer-Lindenberg, Andreas"}],"note":["Gesehen am 07.06.2019"],"relHost":[{"physDesc":[{"extent":"Online-Ressource"}],"language":["eng"],"recId":"660807378","type":{"media":"Online-Ressource","bibl":"periodical"},"disp":"Species-conserved reconfigurations of brain network topology induced by ketamineTranslational Psychiatry","note":["Gesehen am 17.05.11"],"title":[{"title_sort":"Translational Psychiatry","title":"Translational Psychiatry"}],"pubHistory":["1.2011 -"],"origin":[{"publisherPlace":"London","dateIssuedKey":"2011","dateIssuedDisp":"2011-","publisher":"Nature Publishing Group"}],"part":{"text":"6(2016,4) Artikel-Nummer e786, 7 Seiten","volume":"6","extent":"7","year":"2016","issue":"4"},"id":{"eki":["660807378"],"issn":["2158-3188"],"zdb":["2609311-X"]}}],"type":{"bibl":"article-journal","media":"Online-Ressource"},"recId":"1667001353","language":["eng"],"physDesc":[{"extent":"7 S."}],"name":{"displayForm":["R. Becker, U. Braun, A.J. Schwarz, N. Gass, J.I. Schweiger, W. Weber-Fahr, E. Schenker, M. Spedding, C. Clemm von Hohenberg, C. Risterucci, Z. Zang, O. Grimm, H. Tost, A. Sartorius and A. Meyer-Lindenberg"]}} | ||
| SRT | |a BECKERROBESPECIESCON1920 | ||