Cover Image

Experimental ischaemic stroke induces transient cardiac atrophy and dysfunction

Background Stroke can lead to cardiac dysfunction in patients, but the mechanisms underlying the interaction between the injured brain and the heart are poorly understood. The objective of the study is to investigate the effects of experimental murine stroke on cardiac function and molecular signall...

Full description

Saved in:
Bibliographic Details
Main Authors: Veltkamp, Roland (Author) , Uhlmann, Stefan (Author) , Marinescu, Marilena (Author) , Sticht, Carsten (Author) , Finke, Daniel (Author) , Gretz, Norbert (Author) , Gröne, Hermann-Josef (Author) , Katus, Hugo (Author) , Backs, Johannes (Author) , Lehmann, Lorenz (Author)
Format: Article (Journal)
Language:English
Published: [February 2019]
In: Journal of cachexia, sarcopenia and muscle
Year: 2018, Volume: 10, Issue: 1, Pages: 54-62
ISSN:2190-6009
DOI:10.1002/jcsm.12335
Online Access:Verlag, Volltext: https://doi.org/10.1002/jcsm.12335
Verlag, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/jcsm.12335
Get full text
Author Notes:Roland Veltkamp, Stefan Uhlmann, Marilena Marinescu, Carsten Sticht, Daniel Finke, Norbert Gretz, Herrmann-Josef Gröne, Hugo A. Katus, Johannes Backs & Lorenz H. Lehmann

MARC

LEADER 00000caa a2200000 c 4500
001 1667579142
003 DE-627
005 20220816172411.0
007 cr uuu---uuuuu
008 190618r20192018xx |||||o 00| ||eng c
024 7 |a 10.1002/jcsm.12335  |2 doi 
035 |a (DE-627)1667579142 
035 |a (DE-599)KXP1667579142 
035 |a (OCoLC)1341228899 
040 |a DE-627  |b ger  |c DE-627  |e rda 
041 |a eng 
084 |a 33  |2 sdnb 
100 1 |a Veltkamp, Roland  |d 1966-  |e VerfasserIn  |0 (DE-588)172858453  |0 (DE-627)697787567  |0 (DE-576)133713997  |4 aut 
245 1 0 |a Experimental ischaemic stroke induces transient cardiac atrophy and dysfunction  |c Roland Veltkamp, Stefan Uhlmann, Marilena Marinescu, Carsten Sticht, Daniel Finke, Norbert Gretz, Herrmann-Josef Gröne, Hugo A. Katus, Johannes Backs & Lorenz H. Lehmann 
264 1 |c [February 2019] 
300 |b Illustrationen 
300 |a 9 
336 |a Text  |b txt  |2 rdacontent 
337 |a Computermedien  |b c  |2 rdamedia 
338 |a Online-Ressource  |b cr  |2 rdacarrier 
500 |a First published: 30 October 2018 
500 |a Gesehen am 18.06.2019 
520 |a Background Stroke can lead to cardiac dysfunction in patients, but the mechanisms underlying the interaction between the injured brain and the heart are poorly understood. The objective of the study is to investigate the effects of experimental murine stroke on cardiac function and molecular signalling in the heart. Methods and results Mice were subjected to filament-induced left middle cerebral artery occlusion for 30 or 60 min or sham surgery and underwent repetitive micro-echocardiography. Left ventricular contractility was reduced early (24-72 h) but not late (2 months) after brain ischaemia. Cardiac dysfunction was accompanied by a release of high-sensitive cardiac troponin (hsTNT (ng/ml): d1: 7.0 ± 1.0 vs. 25.0 ± 3.2*; d3: 7.3 ± 1.1 vs. 52.2 ± 16.7*; d14: 5.7 ± 0.8 vs. 5.2 ± 0.3; sham vs. 60 min. MCAO; mean ± SEM; *p < 0.05); reduced heart weight (heart weight/tibia length ratio: d1: 6.9 ± 0.2 vs. 6.4 ± 0.1*; d3: 6.7 ± 0.2 vs. 5.8 ± 0.1*; d14: 6.7 ± 0.2 vs. 6.4 ± 03; sham vs. 60 min. MCAO; mean ± SEM; *p < 0.05); resulting from cardiomyocyte atrophy (cardiomyocyte size: d1: 12.8% ± 0.002**; d3: 13.5% ± 0.002**; 14d: 6.3% ± 0.003*; 60 min. MCAO vs. sham; mean ± SEM; **p < 0.01; *p < 0.05), accompanied by increased atrogin-1 and the E3 ubiquitin ligase murf-1. Net norepinephrine but not synthesis was increased, suggesting a reduced norepinephrine release or an increase of norepinephrine re-uptake, resulting in a functional denervation. Transcriptome analysis in cardiac tissue identified the transcription factor peroxisome proliferator-activated receptor gamma as a potential mediator of stroke-induced transcriptional dysregulation involved in cardiac atrophy. Conclusions Stroke induces a complex molecular response in the heart muscle with immediate but transient cardiac atrophy and dysfunction. 
534 |c 2018 
650 4 |a Atrophy 
650 4 |a Cardiac dysfunction 
650 4 |a Cardiomyocytes 
650 4 |a Ischaemic stroke 
650 4 |a Left ventricular contractility 
700 1 |a Uhlmann, Stefan  |e VerfasserIn  |0 (DE-588)1082569259  |0 (DE-627)847668576  |0 (DE-576)455519889  |4 aut 
700 1 |a Marinescu, Marilena  |e VerfasserIn  |0 (DE-588)1162472138  |0 (DE-627)102617547X  |0 (DE-576)507428501  |4 aut 
700 1 |a Sticht, Carsten  |d 1972-  |e VerfasserIn  |0 (DE-588)1020115718  |0 (DE-627)691110077  |0 (DE-576)250042177  |4 aut 
700 1 |a Finke, Daniel  |d 1988-  |e VerfasserIn  |0 (DE-588)1148566899  |0 (DE-627)1008764876  |0 (DE-576)496329553  |4 aut 
700 1 |a Gretz, Norbert  |d 1954-2023  |e VerfasserIn  |0 (DE-588)1020104589  |0 (DE-627)691105154  |0 (DE-576)359544843  |4 aut 
700 1 |a Gröne, Hermann-Josef  |d 1950-  |e VerfasserIn  |0 (DE-588)1054822697  |0 (DE-627)792339541  |0 (DE-576)170213773  |4 aut 
700 1 |a Katus, Hugo  |d 1951-  |e VerfasserIn  |0 (DE-588)108916618  |0 (DE-627)577155040  |0 (DE-576)289625076  |4 aut 
700 1 |a Backs, Johannes  |d 1971-  |e VerfasserIn  |0 (DE-588)123819040  |0 (DE-627)706437462  |0 (DE-576)293892946  |4 aut 
700 1 |a Lehmann, Lorenz  |d 1980-  |e VerfasserIn  |0 (DE-588)131855212  |0 (DE-627)515807184  |0 (DE-576)298796104  |4 aut 
773 0 8 |i Enthalten in  |t Journal of cachexia, sarcopenia and muscle  |d Hoboken, NJ : Wiley, 2010  |g 10(2019), 1, Seite 54-62  |h Online-Ressource  |w (DE-627)642886121  |w (DE-600)2586864-0  |w (DE-576)335781330  |x 2190-6009  |7 nnas  |a Experimental ischaemic stroke induces transient cardiac atrophy and dysfunction 
773 1 8 |g volume:10  |g year:2019  |g number:1  |g pages:54-62  |g extent:9  |a Experimental ischaemic stroke induces transient cardiac atrophy and dysfunction 
856 4 0 |u https://doi.org/10.1002/jcsm.12335  |x Verlag  |x Resolving-System  |3 Volltext 
856 4 0 |u https://onlinelibrary.wiley.com/doi/abs/10.1002/jcsm.12335  |x Verlag  |3 Volltext 
951 |a AR 
992 |a 20190618 
993 |a Article 
994 |a 2019 
998 |g 131855212  |a Lehmann, Lorenz  |m 131855212:Lehmann, Lorenz  |d 910000  |d 910100  |e 910000PL131855212  |e 910100PL131855212  |k 0/910000/  |k 1/910000/910100/  |p 10  |y j 
998 |g 123819040  |a Backs, Johannes  |m 123819040:Backs, Johannes  |d 910000  |d 910100  |e 910000PB123819040  |e 910100PB123819040  |k 0/910000/  |k 1/910000/910100/  |p 9 
998 |g 108916618  |a Katus, Hugo  |m 108916618:Katus, Hugo  |d 910000  |d 910100  |e 910000PK108916618  |e 910100PK108916618  |k 0/910000/  |k 1/910000/910100/  |p 8 
998 |g 1054822697  |a Gröne, Hermann-Josef  |m 1054822697:Gröne, Hermann-Josef  |d 50000  |e 50000PG1054822697  |k 0/50000/  |p 7 
998 |g 1020104589  |a Gretz, Norbert  |m 1020104589:Gretz, Norbert  |d 60000  |d 999811  |e 60000PG1020104589  |e 999811PG1020104589  |k 0/60000/  |k 1/60000/999811/  |p 6 
998 |g 1148566899  |a Finke, Daniel  |m 1148566899:Finke, Daniel  |d 910000  |d 910100  |e 910000PF1148566899  |e 910100PF1148566899  |k 0/910000/  |k 1/910000/910100/  |p 5 
998 |g 1020115718  |a Sticht, Carsten  |m 1020115718:Sticht, Carsten  |d 60000  |d 999811  |e 60000PS1020115718  |e 999811PS1020115718  |k 0/60000/  |k 1/60000/999811/  |p 4 
998 |g 172858453  |a Veltkamp, Roland  |m 172858453:Veltkamp, Roland  |d 910000  |d 911100  |e 910000PV172858453  |e 911100PV172858453  |k 0/910000/  |k 1/910000/911100/  |p 1  |x j 
999 |a KXP-PPN1667579142  |e 348814657X 
BIB |a Y 
SER |a journal 
JSO |a {"note":["First published: 30 October 2018","Gesehen am 18.06.2019"],"relHost":[{"title":[{"title":"Journal of cachexia, sarcopenia and muscle","title_sort":"Journal of cachexia, sarcopenia and muscle"}],"pubHistory":["1.2010 -"],"language":["eng"],"physDesc":[{"extent":"Online-Ressource"}],"type":{"media":"Online-Ressource","bibl":"periodical"},"note":["Gesehen am 16.05.24"],"part":{"year":"2019","issue":"1","extent":"9","text":"10(2019), 1, Seite 54-62","volume":"10","pages":"54-62"},"id":{"eki":["642886121"],"zdb":["2586864-0"],"issn":["2190-6009"]},"origin":[{"publisherPlace":"Hoboken, NJ ; Heidelberg","dateIssuedDisp":"2010-","dateIssuedKey":"2010","publisher":"Wiley ; Springer-Medizin-Verl."}],"disp":"Experimental ischaemic stroke induces transient cardiac atrophy and dysfunctionJournal of cachexia, sarcopenia and muscle","recId":"642886121"}],"language":["eng"],"physDesc":[{"noteIll":"Illustrationen","extent":"9 S."}],"type":{"media":"Online-Ressource","bibl":"article-journal"},"title":[{"title_sort":"Experimental ischaemic stroke induces transient cardiac atrophy and dysfunction","title":"Experimental ischaemic stroke induces transient cardiac atrophy and dysfunction"}],"person":[{"display":"Veltkamp, Roland","family":"Veltkamp","role":"aut","given":"Roland"},{"given":"Stefan","role":"aut","family":"Uhlmann","display":"Uhlmann, Stefan"},{"given":"Marilena","role":"aut","family":"Marinescu","display":"Marinescu, Marilena"},{"given":"Carsten","role":"aut","family":"Sticht","display":"Sticht, Carsten"},{"display":"Finke, Daniel","family":"Finke","given":"Daniel","role":"aut"},{"display":"Gretz, Norbert","family":"Gretz","given":"Norbert","role":"aut"},{"display":"Gröne, Hermann-Josef","given":"Hermann-Josef","role":"aut","family":"Gröne"},{"display":"Katus, Hugo","given":"Hugo","role":"aut","family":"Katus"},{"family":"Backs","role":"aut","given":"Johannes","display":"Backs, Johannes"},{"family":"Lehmann","role":"aut","given":"Lorenz","display":"Lehmann, Lorenz"}],"recId":"1667579142","name":{"displayForm":["Roland Veltkamp, Stefan Uhlmann, Marilena Marinescu, Carsten Sticht, Daniel Finke, Norbert Gretz, Herrmann-Josef Gröne, Hugo A. Katus, Johannes Backs & Lorenz H. Lehmann"]},"origin":[{"dateIssuedKey":"2019","dateIssuedDisp":"[February 2019]"}],"id":{"eki":["1667579142"],"doi":["10.1002/jcsm.12335"]}} 
SRT |a VELTKAMPROEXPERIMENT2019 

Similar Items