Radiofluorinated N-Octanoyl Dopamine ([18F]F-NOD) as a tool to study tissue distribution and elimination of NOD in vitro and in vivo
To mitigate pretransplantation injury in organs of potential donors, N-octanoyl dopamine (NOD) treatment might be considered as it does not affect hemodynamic parameters in braindead (BD) donors. To better assess optimal NOD concentrations for donor treatment, we report on the fast and facile radiof...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
October 12, 2016
|
| In: |
Journal of medicinal chemistry
Year: 2016, Jahrgang: 59, Heft: 21, Pages: 9855-9865 |
| ISSN: | 1520-4804 |
| DOI: | 10.1021/acs.jmedchem.6b01191 |
| Online-Zugang: | Verlag, Volltext: https://doi.org/10.1021/acs.jmedchem.6b01191
|
| Verfasserangaben: | Marc Pretze, Prama Pallavi, Mareike Roscher, Sarah Klotz, Julio Caballero, Uta Binzen, Wolfgang Greffrath, Rolf-Detlef Treede, Martin C. Harmsen, Mathias Hafner, Benito Yard, Carmen Wängler, and Björn Wängler |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1667614592 | ||
| 003 | DE-627 | ||
| 005 | 20230427035352.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 190618s2016 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1021/acs.jmedchem.6b01191 |2 doi | |
| 035 | |a (DE-627)1667614592 | ||
| 035 | |a (DE-599)KXP1667614592 | ||
| 035 | |a (OCoLC)1341228492 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Pretze, Marc |d 1983- |e VerfasserIn |0 (DE-588)1054783837 |0 (DE-627)792109120 |0 (DE-576)410510602 |4 aut | |
| 245 | 1 | 0 | |a Radiofluorinated N-Octanoyl Dopamine ([18F]F-NOD) as a tool to study tissue distribution and elimination of NOD in vitro and in vivo |c Marc Pretze, Prama Pallavi, Mareike Roscher, Sarah Klotz, Julio Caballero, Uta Binzen, Wolfgang Greffrath, Rolf-Detlef Treede, Martin C. Harmsen, Mathias Hafner, Benito Yard, Carmen Wängler, and Björn Wängler |
| 264 | 1 | |c October 12, 2016 | |
| 300 | |a 11 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 18.06.2019 | ||
| 520 | |a To mitigate pretransplantation injury in organs of potential donors, N-octanoyl dopamine (NOD) treatment might be considered as it does not affect hemodynamic parameters in braindead (BD) donors. To better assess optimal NOD concentrations for donor treatment, we report on the fast and facile radiofluorination of the NOD-derivative [18F]F-NOD [18F]5 for in vivo assessment of NOD’s elimination kinetics by means of PET imaging. [18F]5 was synthesized in reproducibly high radiochemical yields and purity (>98%) as well as high specific activities (>20 GBq/μmol). Stability tests showed no decomposition of [18F]5 over a period of 120 min in rat plasma. In vitro, low cell association was found for [18F]5, indicating no active transport mechanism into cells. In vivo, [18F]5 exhibited a fast blood clearance and a predominant hepatobiliary elimination. As these data suggest that also NOD might be cleared fast, further pharmacokinetic evaluation is warranted. | ||
| 700 | 1 | |a Pallavi, Prama |d 1987- |e VerfasserIn |0 (DE-588)1082096598 |0 (DE-627)847104850 |0 (DE-576)45510025X |4 aut | |
| 700 | 1 | |a Klotz, Sarah |d 1984- |e VerfasserIn |0 (DE-588)1066267715 |0 (DE-627)817154442 |0 (DE-576)425712540 |4 aut | |
| 700 | 1 | |a Binzen, Uta |d 1972- |e VerfasserIn |0 (DE-588)134249100 |0 (DE-627)565616366 |0 (DE-576)300402457 |4 aut | |
| 700 | 1 | |a Greffrath, Wolfgang |d 1966- |e VerfasserIn |0 (DE-588)12178424X |0 (DE-627)705652637 |0 (DE-576)292883528 |4 aut | |
| 700 | 1 | |a Treede, Rolf-Detlef |d 1956- |e VerfasserIn |0 (DE-588)109865960 |0 (DE-627)606699856 |0 (DE-576)309492459 |4 aut | |
| 700 | 1 | |a Yard, Benito A. |d 1961- |e VerfasserIn |0 (DE-588)1025110633 |0 (DE-627)721145892 |0 (DE-576)369951735 |4 aut | |
| 700 | 1 | |a Wängler, Carmen |d 1978- |e VerfasserIn |0 (DE-588)133775593 |0 (DE-627)556368177 |0 (DE-576)30009230X |4 aut | |
| 700 | 1 | |a Wängler, Björn |d 1975- |e VerfasserIn |0 (DE-588)129702218 |0 (DE-627)477593909 |0 (DE-576)297793888 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Journal of medicinal chemistry |d Washington, DC : ACS, 1959 |g 59(2016), 21, Seite 9855-9865 |h Online-Ressource |w (DE-627)302468846 |w (DE-600)1491411-6 |w (DE-576)090855132 |x 1520-4804 |7 nnas |a Radiofluorinated N-Octanoyl Dopamine ([18F]F-NOD) as a tool to study tissue distribution and elimination of NOD in vitro and in vivo |
| 773 | 1 | 8 | |g volume:59 |g year:2016 |g number:21 |g pages:9855-9865 |g extent:11 |a Radiofluorinated N-Octanoyl Dopamine ([18F]F-NOD) as a tool to study tissue distribution and elimination of NOD in vitro and in vivo |
| 856 | 4 | 0 | |u https://doi.org/10.1021/acs.jmedchem.6b01191 |x Verlag |x Resolving-System |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20190618 | ||
| 993 | |a Article | ||
| 994 | |a 2016 | ||
| 998 | |g 129702218 |a Wängler, Björn |m 129702218:Wängler, Björn |d 60000 |d 62900 |e 60000PW129702218 |e 62900PW129702218 |k 0/60000/ |k 1/60000/62900/ |p 13 |y j | ||
| 998 | |g 133775593 |a Wängler, Carmen |m 133775593:Wängler, Carmen |d 60000 |d 62900 |e 60000PW133775593 |e 62900PW133775593 |k 0/60000/ |k 1/60000/62900/ |p 12 | ||
| 998 | |g 1025110633 |a Yard, Benito A. |m 1025110633:Yard, Benito A. |d 60000 |d 61400 |e 60000PY1025110633 |e 61400PY1025110633 |k 0/60000/ |k 1/60000/61400/ |p 11 | ||
| 998 | |g 109865960 |a Treede, Rolf-Detlef |m 109865960:Treede, Rolf-Detlef |d 60000 |d 62900 |e 60000PT109865960 |e 62900PT109865960 |k 0/60000/ |k 1/60000/62900/ |p 8 | ||
| 998 | |g 12178424X |a Greffrath, Wolfgang |m 12178424X:Greffrath, Wolfgang |d 60000 |d 999810 |e 60000PG12178424X |e 999810PG12178424X |k 0/60000/ |k 1/60000/999810/ |p 7 | ||
| 998 | |g 134249100 |a Binzen, Uta |m 134249100:Binzen, Uta |d 60000 |d 999810 |e 60000PB134249100 |e 999810PB134249100 |k 0/60000/ |k 1/60000/999810/ |p 6 | ||
| 998 | |g 1066267715 |a Klotz, Sarah |m 1066267715:Klotz, Sarah |d 60000 |d 61400 |e 60000PK1066267715 |e 61400PK1066267715 |k 0/60000/ |k 1/60000/61400/ |p 4 | ||
| 998 | |g 1082096598 |a Pallavi, Prama |m 1082096598:Pallavi, Prama |d 60000 |d 61400 |e 60000PP1082096598 |e 61400PP1082096598 |k 0/60000/ |k 1/60000/61400/ |p 2 | ||
| 998 | |g 1054783837 |a Pretze, Marc |m 1054783837:Pretze, Marc |d 60000 |d 62900 |e 60000PP1054783837 |e 62900PP1054783837 |k 0/60000/ |k 1/60000/62900/ |p 1 |x j | ||
| 999 | |a KXP-PPN1667614592 |e 3488226433 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"person":[{"given":"Marc","family":"Pretze","display":"Pretze, Marc","role":"aut"},{"given":"Prama","display":"Pallavi, Prama","family":"Pallavi","role":"aut"},{"role":"aut","display":"Klotz, Sarah","family":"Klotz","given":"Sarah"},{"role":"aut","display":"Binzen, Uta","family":"Binzen","given":"Uta"},{"display":"Greffrath, Wolfgang","family":"Greffrath","role":"aut","given":"Wolfgang"},{"given":"Rolf-Detlef","role":"aut","display":"Treede, Rolf-Detlef","family":"Treede"},{"given":"Benito A.","role":"aut","family":"Yard","display":"Yard, Benito A."},{"family":"Wängler","display":"Wängler, Carmen","role":"aut","given":"Carmen"},{"given":"Björn","role":"aut","family":"Wängler","display":"Wängler, Björn"}],"type":{"bibl":"article-journal","media":"Online-Ressource"},"relHost":[{"recId":"302468846","type":{"bibl":"periodical","media":"Online-Ressource"},"pubHistory":["1.1959 -"],"part":{"extent":"11","issue":"21","year":"2016","text":"59(2016), 21, Seite 9855-9865","pages":"9855-9865","volume":"59"},"disp":"Radiofluorinated N-Octanoyl Dopamine ([18F]F-NOD) as a tool to study tissue distribution and elimination of NOD in vitro and in vivoJournal of medicinal chemistry","origin":[{"publisher":"ACS ; ACS","dateIssuedKey":"1959","publisherPlace":"Washington, DC ; Easton, Pa.","dateIssuedDisp":"1959-"}],"id":{"zdb":["1491411-6"],"eki":["302468846"],"issn":["1520-4804"]},"note":["Gesehen am 02.10.2020"],"name":{"displayForm":["American Chemical Society"]},"title":[{"title":"Journal of medicinal chemistry","title_sort":"Journal of medicinal chemistry"}],"physDesc":[{"extent":"Online-Ressource"}],"language":["eng"]}],"origin":[{"dateIssuedKey":"2016","dateIssuedDisp":"October 12, 2016"}],"recId":"1667614592","id":{"eki":["1667614592"],"doi":["10.1021/acs.jmedchem.6b01191"]},"physDesc":[{"extent":"11 S."}],"title":[{"title":"Radiofluorinated N-Octanoyl Dopamine ([18F]F-NOD) as a tool to study tissue distribution and elimination of NOD in vitro and in vivo","title_sort":"Radiofluorinated N-Octanoyl Dopamine ([18F]F-NOD) as a tool to study tissue distribution and elimination of NOD in vitro and in vivo"}],"language":["eng"],"note":["Gesehen am 18.06.2019"],"name":{"displayForm":["Marc Pretze, Prama Pallavi, Mareike Roscher, Sarah Klotz, Julio Caballero, Uta Binzen, Wolfgang Greffrath, Rolf-Detlef Treede, Martin C. Harmsen, Mathias Hafner, Benito Yard, Carmen Wängler, and Björn Wängler"]}} | ||
| SRT | |a PRETZEMARCRADIOFLUOR1220 | ||