Expression of IL-17F is associated with non-pathogenic Th17 cells
IL-17A and IL-17F share the highest sequence homology of the IL-17 family and signal via the same IL-17RA/RC receptor heterodimer. To better explore the expression of these two cytokines, we used a double reporter mouse strain (IL-17DR mice), where IL-17A expressing cells are marked by enhanced gree...
Gespeichert in:
| Hauptverfasser: | , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
29 June 2018
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| In: |
Journal of molecular medicine
Year: 2018, Jahrgang: 96, Heft: 8, Pages: 819-829 |
| ISSN: | 1432-1440 |
| DOI: | 10.1007/s00109-018-1662-5 |
| Online-Zugang: | Verlag, Volltext: http://dx.doi.org/10.1007/s00109-018-1662-5
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| Verfasserangaben: | Florian Wanke, Yilang Tang, Konrad Gronke, Sabrina Klebow, Sonja Moos, Judith Hauptmann, Arthi Shanmugavadivu, Tommy Regen, Ilgiz A. Mufazalov, Lauren A. Gabriel, Sonja Reißig, Andreas Diefenbach, Florian C. Kurschus, Ari Waisman |
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| 245 | 1 | 0 | |a Expression of IL-17F is associated with non-pathogenic Th17 cells |c Florian Wanke, Yilang Tang, Konrad Gronke, Sabrina Klebow, Sonja Moos, Judith Hauptmann, Arthi Shanmugavadivu, Tommy Regen, Ilgiz A. Mufazalov, Lauren A. Gabriel, Sonja Reißig, Andreas Diefenbach, Florian C. Kurschus, Ari Waisman |
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| 520 | |a IL-17A and IL-17F share the highest sequence homology of the IL-17 family and signal via the same IL-17RA/RC receptor heterodimer. To better explore the expression of these two cytokines, we used a double reporter mouse strain (IL-17DR mice), where IL-17A expressing cells are marked by enhanced green fluorescent protein (eGFP) while red fluorescence protein (RFP) reports the expression of IL-17F. In steady state, we found that Th17 and γδ T cells only expressed IL-17A, while IL-17F expression was restricted to CD8 T cells (Tc17) and innate lymphoid cells (ILC type 3) of the gut. In experimental autoimmune encephalomyelitis, the vast majority of CNS-infiltrating Th17 cells expressed IL-17A but not IL-17F. In contrast, anti-CD3-induced, TGF-β-driven Th17 cells in the gut expressed both of these IL-17 cytokines. In line with this, in vitro differentiation of Th17 cells in the presence of IL-1β led primarily to IL-17A expressing T cells, while TGF-β induced IL-17F co-expressing Th17 cells. Our results suggest that expression of IL-17F is associated with non-pathogenic T cells, pointing to a differential function of IL-17A versus IL-17F. - KEY MESSAGES: Naïve mice: CD4+ T cells and γδ T cells express IL-17A, and Tc17 cells express IL-17F. Gut ILC3 show differential expression of IL17A and F. Th17 differentiation with TGF-β1 induces IL-17A and F, whereas IL-1β induced cells expressing IL-17A. Th17 cells in EAE in CNS express IL-17A only. Gut Th17 cells induced by anti-CD3 express IL-17A and F together as skin γδ T cells of IMQ-treated mice. | ||
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