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Semiautomatic whole-lesion apparent diffusion coefficient assessment for early prediction of liver tumor response to radioembolization

Aim: To evaluate volume-based apparent diffusion coefficient (ADCVOL) values for early prediction of therapy response after radioembolization (RE) of primary and secondary liver malignancies using a semiautomatic, image analysis software prototype. Patients and Methods: In a retrospective analysis,...

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Main Authors: Rathmann, Nils-Andreas (Author) , Budjan, Johannes (Author) , Attenberger, Ulrike (Author) , Kostrzewa, Michael (Author) , Sadick, Maliha (Author) , Schönberg, Stefan (Author) , Diehl, Steffen J. (Author)
Format: Article (Journal)
Language:English
Published: June 2016
In: Anticancer research
Year: 2016, Volume: 36, Issue: 6, Pages: 2961-2966
ISSN:1791-7530
DOI:undefined
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/undefined
Verlag, kostenfrei, Volltext: http://ar.iiarjournals.org/content/36/6/2961
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Author Notes:Nils Rathmann, Johannes Budjan, Fatinah Mari, Robert Grimm, Ulrike Attenberger, Michael Kostrzewa, Maliha Sadick, Stefan O. Schoenberg and Steffen J. Diehl
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Summary:Aim: To evaluate volume-based apparent diffusion coefficient (ADCVOL) values for early prediction of therapy response after radioembolization (RE) of primary and secondary liver malignancies using a semiautomatic, image analysis software prototype. Patients and Methods: In a retrospective analysis, 74 target lesions were assessed in terms of therapy response 1 month after RE using magnetic resonance imaging. Changes of the diameter of the target lesions, the mean ADC value in a representative single-slice region of interest (ADCROI) and mean ADCVOL were correlated. Results: The median progression-free interval (PFI) of patients overall was 3.5±5.9 months. PFI in patients with an ADCVOL increase was statistically significantly longer than in patients with an ADCVOL decrease (mean PFI=6.5 vs. 2.5 months; p=0.0374). No correlation between PFI and early changes in lesion diameter or ADCROI was found. Conclusion: Semiautomatic, software-based ADC volume measurements seem to offer a clinically valuable parameter for early prediction of therapy response in patients after RE.
Item Description:Gesehen am 25.06.2019
Physical Description:Online Resource
ISSN:1791-7530
DOI:undefined

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