Semiautomatic whole-lesion apparent diffusion coefficient assessment for early prediction of liver tumor response to radioembolization
Aim: To evaluate volume-based apparent diffusion coefficient (ADCVOL) values for early prediction of therapy response after radioembolization (RE) of primary and secondary liver malignancies using a semiautomatic, image analysis software prototype. Patients and Methods: In a retrospective analysis,...
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| Hauptverfasser: | , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
June 2016
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| In: |
Anticancer research
Year: 2016, Jahrgang: 36, Heft: 6, Pages: 2961-2966 |
| ISSN: | 1791-7530 |
| DOI: | undefined |
| Online-Zugang: | Verlag, kostenfrei, Volltext: https://doi.org/undefined Verlag, kostenfrei, Volltext: http://ar.iiarjournals.org/content/36/6/2961 
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| Verfasserangaben: | Nils Rathmann, Johannes Budjan, Fatinah Mari, Robert Grimm, Ulrike Attenberger, Michael Kostrzewa, Maliha Sadick, Stefan O. Schoenberg and Steffen J. Diehl |
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| 245 | 1 | 0 | |a Semiautomatic whole-lesion apparent diffusion coefficient assessment for early prediction of liver tumor response to radioembolization |c Nils Rathmann, Johannes Budjan, Fatinah Mari, Robert Grimm, Ulrike Attenberger, Michael Kostrzewa, Maliha Sadick, Stefan O. Schoenberg and Steffen J. Diehl |
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| 520 | |a Aim: To evaluate volume-based apparent diffusion coefficient (ADCVOL) values for early prediction of therapy response after radioembolization (RE) of primary and secondary liver malignancies using a semiautomatic, image analysis software prototype. Patients and Methods: In a retrospective analysis, 74 target lesions were assessed in terms of therapy response 1 month after RE using magnetic resonance imaging. Changes of the diameter of the target lesions, the mean ADC value in a representative single-slice region of interest (ADCROI) and mean ADCVOL were correlated. Results: The median progression-free interval (PFI) of patients overall was 3.5±5.9 months. PFI in patients with an ADCVOL increase was statistically significantly longer than in patients with an ADCVOL decrease (mean PFI=6.5 vs. 2.5 months; p=0.0374). No correlation between PFI and early changes in lesion diameter or ADCROI was found. Conclusion: Semiautomatic, software-based ADC volume measurements seem to offer a clinically valuable parameter for early prediction of therapy response in patients after RE. | ||
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| 650 | 4 | |a semiautomatic analysis | |
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