Activation of glial glutamate transporter via MAPK p38 prevents enhanced and long-lasting non-evoked resting pain after surgical incision in rats
Pain after surgery has recently become a major issue not only due to lack of treatment success in the acute phase; even more alarming is the large number of patients developing prolonged pain after surgery. Because spinal glutamate as well as spinal glia plays a major role in acute incisional pain,...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
23 February 2016
|
| In: |
Neuropharmacology
Year: 2016, Volume: 105, Pages: 607-617 |
| ISSN: | 1873-7064 |
| DOI: | 10.1016/j.neuropharm.2016.02.024 |
| Online Access: | Verlag, Volltext: https://doi.org/10.1016/j.neuropharm.2016.02.024 Verlag, Volltext: http://www.sciencedirect.com/science/article/pii/S0028390816300594 
|
| Author Notes: | Sylvia Reichl, Daniel Segelcke, Viktor Keller, Robin Jonas, Armin Boecker, Manuel Wenk, Dagmar Evers, Peter K. Zahn, Esther M. Pogatzki-Zahn |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1667932063 | ||
| 003 | DE-627 | ||
| 005 | 20240323101140.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 190625s2016 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/j.neuropharm.2016.02.024 |2 doi | |
| 035 | |a (DE-627)1667932063 | ||
| 035 | |a (DE-599)KXP1667932063 | ||
| 035 | |a (OCoLC)1341230152 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Reichl, Sylvia |d 1976- |e VerfasserIn |0 (DE-588)134235053 |0 (DE-627)564820539 |0 (DE-576)300393555 |4 aut | |
| 245 | 1 | 0 | |a Activation of glial glutamate transporter via MAPK p38 prevents enhanced and long-lasting non-evoked resting pain after surgical incision in rats |c Sylvia Reichl, Daniel Segelcke, Viktor Keller, Robin Jonas, Armin Boecker, Manuel Wenk, Dagmar Evers, Peter K. Zahn, Esther M. Pogatzki-Zahn |
| 264 | 1 | |c 23 February 2016 | |
| 300 | |a 11 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 25.06.2019 | ||
| 520 | |a Pain after surgery has recently become a major issue not only due to lack of treatment success in the acute phase; even more alarming is the large number of patients developing prolonged pain after surgery. Because spinal glutamate as well as spinal glia plays a major role in acute incisional pain, we investigated the role of the spinal glial glutamate transporters (GT), GLAST, GLT-1, for acute and prolonged pain and hyperalgesia caused by an incision. Spinal administration of the GT-inhibitor DL-TBOA increased non-evoked pain but not evoked pain behavior (hyperalgesia) up to 2 weeks after incision. In accordance, spinal GLAST (and to a lesser degree GLT-1) were upregulated after incision for several days. Long-term incision induced GT upregulation was prevented by long-lasting p38-inhibitor administration but not by long-lasting ERK1/2-inhibition after incision. In accordance, daily treatment with the p38-inhibitor (but not the ERK1/2 inhibitor) prolonged non-evoked but not evoked pain behavior after incision. In electrophysiological experiments, spontaneous activity of high threshold (HT) (but not wide dynamic range (WDR)) neurons known to transmit incision induced non-evoked pain was increased after prolonged treatment with the p38-inhibitor. In conclusion, our findings indicate a new spinal pathway by which non-evoked pain behavior after incision is modulated. The pathway is modality (non-evoked pain) and neuron (HT) specific and disturbance contributes to prolonged long-term pain after surgical incision. This may have therapeutic implications for the treatment of acute and - even more relevant - for prevention of chronic pain after surgery in patients. | ||
| 650 | 4 | |a Glia interaction | |
| 650 | 4 | |a Glutamate transporter | |
| 650 | 4 | |a Incision model | |
| 650 | 4 | |a Neurotransmitter | |
| 650 | 4 | |a Postoperative pain | |
| 700 | 1 | |a Jonas, Robin |d 1980- |e VerfasserIn |0 (DE-588)1106406664 |0 (DE-627)863121705 |0 (DE-576)474067521 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Neuropharmacology |d Amsterdam [u.a.] : Elsevier Science, 1970 |g 105(2016), Seite 607-617 |h Online-Ressource |w (DE-627)30666125X |w (DE-600)1500655-4 |w (DE-576)081986831 |x 1873-7064 |7 nnas |a Activation of glial glutamate transporter via MAPK p38 prevents enhanced and long-lasting non-evoked resting pain after surgical incision in rats |
| 773 | 1 | 8 | |g volume:105 |g year:2016 |g pages:607-617 |g extent:11 |a Activation of glial glutamate transporter via MAPK p38 prevents enhanced and long-lasting non-evoked resting pain after surgical incision in rats |
| 856 | 4 | 0 | |u https://doi.org/10.1016/j.neuropharm.2016.02.024 |x Verlag |x Resolving-System |3 Volltext |
| 856 | 4 | 0 | |u http://www.sciencedirect.com/science/article/pii/S0028390816300594 |x Verlag |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20190625 | ||
| 993 | |a Article | ||
| 994 | |a 2016 | ||
| 998 | |g 1106406664 |a Jonas, Robin |m 1106406664:Jonas, Robin |d 60000 |d 61600 |e 60000PJ1106406664 |e 61600PJ1106406664 |k 0/60000/ |k 1/60000/61600/ |p 4 | ||
| 999 | |a KXP-PPN1667932063 |e 3489707559 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"origin":[{"dateIssuedKey":"2016","dateIssuedDisp":"23 February 2016"}],"id":{"doi":["10.1016/j.neuropharm.2016.02.024"],"eki":["1667932063"]},"name":{"displayForm":["Sylvia Reichl, Daniel Segelcke, Viktor Keller, Robin Jonas, Armin Boecker, Manuel Wenk, Dagmar Evers, Peter K. Zahn, Esther M. Pogatzki-Zahn"]},"physDesc":[{"extent":"11 S."}],"relHost":[{"part":{"year":"2016","pages":"607-617","volume":"105","text":"105(2016), Seite 607-617","extent":"11"},"pubHistory":["9.1970 -"],"recId":"30666125X","language":["eng"],"note":["Gesehen am 20.02.20"],"type":{"media":"Online-Ressource","bibl":"periodical"},"disp":"Activation of glial glutamate transporter via MAPK p38 prevents enhanced and long-lasting non-evoked resting pain after surgical incision in ratsNeuropharmacology","title":[{"title":"Neuropharmacology","title_sort":"Neuropharmacology"}],"physDesc":[{"extent":"Online-Ressource"}],"id":{"issn":["1873-7064"],"eki":["30666125X"],"zdb":["1500655-4"]},"origin":[{"dateIssuedDisp":"1970-","publisher":"Elsevier Science","dateIssuedKey":"1970","publisherPlace":"Amsterdam [u.a.]"}]}],"title":[{"title":"Activation of glial glutamate transporter via MAPK p38 prevents enhanced and long-lasting non-evoked resting pain after surgical incision in rats","title_sort":"Activation of glial glutamate transporter via MAPK p38 prevents enhanced and long-lasting non-evoked resting pain after surgical incision in rats"}],"person":[{"role":"aut","display":"Reichl, Sylvia","roleDisplay":"VerfasserIn","given":"Sylvia","family":"Reichl"},{"family":"Jonas","given":"Robin","display":"Jonas, Robin","roleDisplay":"VerfasserIn","role":"aut"}],"type":{"media":"Online-Ressource","bibl":"article-journal"},"note":["Gesehen am 25.06.2019"],"recId":"1667932063","language":["eng"]} | ||
| SRT | |a REICHLSYLVACTIVATION2320 | ||