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Functional linkage of gene fusions to cancer cell fitness assessed by pharmacological and CRISPR-Cas9 screening

Gene fusions are observed in many cancers but their link to tumour fitness is largely unknown. Here, transcriptomic analysis combined with pharmacological and CRISPR-Cas9 screening of cancer cell lines was used to evaluate the functional linkage between fusions and tumour fitness.

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Bibliographische Detailangaben
Hauptverfasser: Picco, Gabriele (VerfasserIn) , Chen, Elisabeth D. (VerfasserIn) , Sáez Rodríguez, Julio (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 16 May 2019
In: Nature Communications
Year: 2019, Jahrgang: 10
ISSN:2041-1723
DOI:10.1038/s41467-019-09940-1
Online-Zugang:Verlag, Volltext: https://doi.org/10.1038/s41467-019-09940-1
Verlag, Volltext: https://www.nature.com/articles/s41467-019-09940-1
Volltext
Verfasserangaben:Gabriele Picco, Elisabeth D. Chen, Luz Garcia Alonso, Fiona M. Behan, Emanuel Gonçalves, Graham Bignell, Angela Matchan, Beiyuan Fu, Ruby Banerjee, Elizabeth Anderson, Adam Butler, Cyril H. Benes, Ultan McDermott, David Dow, Francesco Iorio, Euan Stronach, Fengtang Yang, Kosuke Yusa, Julio Saez-Rodriguez & Mathew J. Garnett

MARC

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