Functional linkage of gene fusions to cancer cell fitness assessed by pharmacological and CRISPR-Cas9 screening
Gene fusions are observed in many cancers but their link to tumour fitness is largely unknown. Here, transcriptomic analysis combined with pharmacological and CRISPR-Cas9 screening of cancer cell lines was used to evaluate the functional linkage between fusions and tumour fitness.
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| Main Authors: | , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
16 May 2019
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| In: |
Nature Communications
Year: 2019, Volume: 10 |
| ISSN: | 2041-1723 |
| DOI: | 10.1038/s41467-019-09940-1 |
| Online Access: | Verlag, Volltext: https://doi.org/10.1038/s41467-019-09940-1 Verlag, Volltext: https://www.nature.com/articles/s41467-019-09940-1 
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| Author Notes: | Gabriele Picco, Elisabeth D. Chen, Luz Garcia Alonso, Fiona M. Behan, Emanuel Gonçalves, Graham Bignell, Angela Matchan, Beiyuan Fu, Ruby Banerjee, Elizabeth Anderson, Adam Butler, Cyril H. Benes, Ultan McDermott, David Dow, Francesco Iorio, Euan Stronach, Fengtang Yang, Kosuke Yusa, Julio Saez-Rodriguez & Mathew J. Garnett |
| Summary: | Gene fusions are observed in many cancers but their link to tumour fitness is largely unknown. Here, transcriptomic analysis combined with pharmacological and CRISPR-Cas9 screening of cancer cell lines was used to evaluate the functional linkage between fusions and tumour fitness. |
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| Item Description: | Gabriele Picco and Elisabeth D. Chen contributed equally Gesehen am 26.06.2019 |
| Physical Description: | Online Resource |
| ISSN: | 2041-1723 |
| DOI: | 10.1038/s41467-019-09940-1 |