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Influence of regioselectively sulfated cellulose on in Vitrovascularization of biomimetic bone matrices

ABSTRACT:Vascularization is essential for the regeneration of bone tissue within composite material. We measured the effectof regioselectively modified cellulose/hemicellulose as an additive for porous scaffolds of collagen/hydroxyapatitenanocomposite on the tubule formation of human vascular endoth...

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Hauptverfasser: Weber, Dominik (VerfasserIn) , Andrulis, Mindaugas (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: September 25, 2018
In: Biomacromolecules
Year: 2018, Jahrgang: 19, Heft: 11, Pages: 4228-4238
ISSN:1526-4602
DOI:10.1021/acs.biomac.8b01004
Online-Zugang:Verlag, Volltext: http://dx.doi.org/10.1021/acs.biomac.8b01004
Volltext
Verfasserangaben:Dominik Weber, Sven Knaak, Kay Hettrich, Mindaugas Andrulis, Frank Momburg, Mandy Quade, Michael Gelinsky, and Reinhard Schwartz-Albiez
Beschreibung
Zusammenfassung:ABSTRACT:Vascularization is essential for the regeneration of bone tissue within composite material. We measured the effectof regioselectively modified cellulose/hemicellulose as an additive for porous scaffolds of collagen/hydroxyapatitenanocomposite on the tubule formation of human vascular endothelial cells. Using a coculture of endothelial cells andfibroblasts, endothelial cells formed a network of tubules within an incubation time of 14 to 24 days. A cellulose sulfate withirregular sulfation pattern along the polysaccharide backbone (13-TACS-01) led to an additional increase in vascular endothelialgrowth factor (VEGF)-induced tubule formation, as observed in an in vitro angiogenesis assays. In contrast with structurallydifferent heparin, these cellulose sulfates have no apparent affinity to VEGF. Their impact on endothelial function may possiblybe due to interactions with cell surface receptors/soluble factors not yet defined.
Beschreibung:Gesehen am 27.06.2019
Beschreibung:Online Resource
ISSN:1526-4602
DOI:10.1021/acs.biomac.8b01004

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