miR-615-5p is restrictedly expressed in cirrhotic and cancerous liver tissues and its overexpression alleviates the tumorigenic effects in hepatocellular carcinoma
microRNAs aberrant behavior in heptocellular carcinoma (HCC) plays a major role in HCC pathogenesis. miR-615-5p expression has never been evaluated in HCC. We showed that miR-615-5p was preferentially expressed in HCC, cirrhotic liver tissues and HCC cell lines, but undetected in normal livers. Forc...
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| Hauptverfasser: | , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
20 July 2012
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| In: |
FEBS letters
Year: 2012, Jahrgang: 586, Heft: 19, Pages: 3309-3316 |
| ISSN: | 1873-3468 |
| DOI: | 10.1016/j.febslet.2012.06.054 |
| Online-Zugang: | Verlag, Volltext: https://doi.org/10.1016/j.febslet.2012.06.054 Verlag, Volltext: https://febs.onlinelibrary.wiley.com/doi/abs/10.1016/j.febslet.2012.06.054 
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| Verfasserangaben: | H.M. El Tayebi, K.A. Hosny, G. Esmat, K. Breuhahn, Ahmed Ihab Abdelaziz |
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| 245 | 1 | 0 | |a miR-615-5p is restrictedly expressed in cirrhotic and cancerous liver tissues and its overexpression alleviates the tumorigenic effects in hepatocellular carcinoma |c H.M. El Tayebi, K.A. Hosny, G. Esmat, K. Breuhahn, Ahmed Ihab Abdelaziz |
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| 520 | |a microRNAs aberrant behavior in heptocellular carcinoma (HCC) plays a major role in HCC pathogenesis. miR-615-5p expression has never been evaluated in HCC. We showed that miR-615-5p was preferentially expressed in HCC, cirrhotic liver tissues and HCC cell lines, but undetected in normal livers. Forced miR-615-5p expression in HCC cell lines led to significant decrease in cell growth and migration. In-silico predication revealed insulin-like growth factor-II (IGF-II) as a potential downstream target for miR-615-5p. Forcing the expression of miR-615-5p showed downregulation of IGF-II mRNA, as well as inhibition of the luciferase activity in a luciferase reporter vector harboring the IGF-II-3′UTR target sequence. miR-615-5p acts as tumor-suppressor in HCC through targeting IGF-II. | ||
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