FunResDB-A web resource for genotypic susceptibility testing of Aspergillus fumigatus
Therapy of invasive aspergillosis is becoming more difficult due to the emergence of azole resistance in Aspergillus fumigatus. A majority of resistant strains carries mutations in the CYP51A gene. Due to a lack of sensitivity of culture-based methods, molecular detection of A. fumigatus has become...
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| Main Authors: | , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
2018
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| In: |
Medical mycology
Year: 2017, Volume: 56, Issue: 1, Pages: 117-120 |
| ISSN: | 1460-2709 |
| DOI: | 10.1093/mmy/myx015 |
| Online Access: | Verlag, Volltext: http://dx.doi.org/10.1093/mmy/myx015
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| Author Notes: | Michael Weber, Jonas Schaer, Grit Walther, Kerstin Kaerger, Jörg Steinmann, Peter-Michael Rath, Birgit Spiess, Dieter Buchheidt, Axel Hamprecht and Oliver Kurzai |
| Summary: | Therapy of invasive aspergillosis is becoming more difficult due to the emergence of azole resistance in Aspergillus fumigatus. A majority of resistant strains carries mutations in the CYP51A gene. Due to a lack of sensitivity of culture-based methods, molecular detection of A. fumigatus has become an important diagnostic tool. We set up the database FunResDB (www.nrz-myk.de/funresdb) to gather all available information about CYP51A-dependent azole resistance from published literature. In summary, the screening resulted in 79 CYP51A variants, which are linked to 59 nonsynonymous mutations. A tailor-made online sequence analysis tool allows for genotypic susceptibility testing of A. fumigatus. |
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| Item Description: | Advance Access Publication Date: 11 March 2017 Gesehen am 28.06.2019 |
| Physical Description: | Online Resource |
| ISSN: | 1460-2709 |
| DOI: | 10.1093/mmy/myx015 |