FunResDB-A web resource for genotypic susceptibility testing of Aspergillus fumigatus
Therapy of invasive aspergillosis is becoming more difficult due to the emergence of azole resistance in Aspergillus fumigatus. A majority of resistant strains carries mutations in the CYP51A gene. Due to a lack of sensitivity of culture-based methods, molecular detection of A. fumigatus has become...
Gespeichert in:
| Hauptverfasser: | , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
2018
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| In: |
Medical mycology
Year: 2017, Jahrgang: 56, Heft: 1, Pages: 117-120 |
| ISSN: | 1460-2709 |
| DOI: | 10.1093/mmy/myx015 |
| Online-Zugang: | Verlag, Volltext: http://dx.doi.org/10.1093/mmy/myx015
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| Verfasserangaben: | Michael Weber, Jonas Schaer, Grit Walther, Kerstin Kaerger, Jörg Steinmann, Peter-Michael Rath, Birgit Spiess, Dieter Buchheidt, Axel Hamprecht and Oliver Kurzai |
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| 520 | |a Therapy of invasive aspergillosis is becoming more difficult due to the emergence of azole resistance in Aspergillus fumigatus. A majority of resistant strains carries mutations in the CYP51A gene. Due to a lack of sensitivity of culture-based methods, molecular detection of A. fumigatus has become an important diagnostic tool. We set up the database FunResDB (www.nrz-myk.de/funresdb) to gather all available information about CYP51A-dependent azole resistance from published literature. In summary, the screening resulted in 79 CYP51A variants, which are linked to 59 nonsynonymous mutations. A tailor-made online sequence analysis tool allows for genotypic susceptibility testing of A. fumigatus. | ||
| 534 | |c 2017 | ||
| 650 | 4 | |a Alleles | |
| 650 | 4 | |a Antifungal Agents | |
| 650 | 4 | |a Aspergillus fumigatus | |
| 650 | 4 | |a Azoles | |
| 650 | 4 | |a Cytochrome P-450 Enzyme System | |
| 650 | 4 | |a database | |
| 650 | 4 | |a Databases, Genetic | |
| 650 | 4 | |a drug susceptibility | |
| 650 | 4 | |a fungal infection | |
| 650 | 4 | |a Fungal Proteins | |
| 650 | 4 | |a Genotype | |
| 650 | 4 | |a Genotyping Techniques | |
| 650 | 4 | |a Humans | |
| 650 | 4 | |a Internet | |
| 650 | 4 | |a Microbial Sensitivity Tests | |
| 650 | 4 | |a Polymorphism, Genetic | |
| 650 | 4 | |a triazoles | |
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