MEK inhibitors activate Wnt signalling and induce stem cell plasticity in colorectal cancer
Wnt signaling is necessary for colorectal cancer tumorigenesis and stem cell maintenance. Here, the authors identify MEK1/2 inhibitors as potent activators of Wnt/β-catenin signalling and show that clinically approved MEK inhibitors inadvertently induce stem cell plasticity in colorectal cancer.
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| Hauptverfasser: | , , , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
16 May 2019
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| In: |
Nature Communications
Year: 2019, Jahrgang: 10 |
| ISSN: | 2041-1723 |
| DOI: | 10.1038/s41467-019-09898-0 |
| Online-Zugang: | Verlag, Volltext: https://doi.org/10.1038/s41467-019-09898-0 Verlag, Volltext: https://www.nature.com/articles/s41467-019-09898-0 
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| Verfasserangaben: | Tianzuo Zhan, Giulia Ambrosi, Anna Maxi Wandmacher, Benedikt Rauscher, Johannes Betge, Niklas Rindtorff, Ragna S. Häussler, Isabel Hinsenkamp, Leonhard Bamberg, Bernd Hessling, Karin Müller-Decker, Gerrit Erdmann, Elke Burgermeister, Matthias P. Ebert & Michael Boutros |
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| 520 | |a Wnt signaling is necessary for colorectal cancer tumorigenesis and stem cell maintenance. Here, the authors identify MEK1/2 inhibitors as potent activators of Wnt/β-catenin signalling and show that clinically approved MEK inhibitors inadvertently induce stem cell plasticity in colorectal cancer. | ||
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