Single nucleotide polymorphisms within MUC4 are associated with colorectal cancer survival
Mucins and their glycosylation have been suggested to play an important role in colorectal carcinogenesis. We examined potentially functional genetic variants in the mucin genes or genes involved in their glycosylation with respect to colorectal cancer (CRC) risk and clinical outcome. We genotyped 2...
Gespeichert in:
| Hauptverfasser: | , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
May 15, 2019
|
| In: |
PLOS ONE
Year: 2019, Jahrgang: 14, Heft: 5 |
| ISSN: | 1932-6203 |
| DOI: | 10.1371/journal.pone.0216666 |
| Online-Zugang: | Verlag, Volltext: https://doi.org/10.1371/journal.pone.0216666 Verlag, Volltext: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0216666 
|
| Verfasserangaben: | Shun Lu, Calogerina Catalano, Stefanie Huhn, Barbara Pardini, Linda Partu, Veronika Vymetalkova, Ludmila Vodickova, Miroslav Levy, Thomas Buchler, Kari Hemminki, Pavel Vodicka, Asta Försti |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1668144115 | ||
| 003 | DE-627 | ||
| 005 | 20220816181033.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 190701s2019 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1371/journal.pone.0216666 |2 doi | |
| 035 | |a (DE-627)1668144115 | ||
| 035 | |a (DE-599)KXP1668144115 | ||
| 035 | |a (OCoLC)1341231637 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Lu, Shun |d 1982- |e VerfasserIn |0 (DE-588)1022828142 |0 (DE-627)717047946 |0 (DE-576)362851956 |4 aut | |
| 245 | 1 | 0 | |a Single nucleotide polymorphisms within MUC4 are associated with colorectal cancer survival |c Shun Lu, Calogerina Catalano, Stefanie Huhn, Barbara Pardini, Linda Partu, Veronika Vymetalkova, Ludmila Vodickova, Miroslav Levy, Thomas Buchler, Kari Hemminki, Pavel Vodicka, Asta Försti |
| 264 | 1 | |c May 15, 2019 | |
| 300 | |a 13 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 01.07.2019 | ||
| 520 | |a Mucins and their glycosylation have been suggested to play an important role in colorectal carcinogenesis. We examined potentially functional genetic variants in the mucin genes or genes involved in their glycosylation with respect to colorectal cancer (CRC) risk and clinical outcome. We genotyped 23 single nucleotide polymorphisms (SNPs) covering 123 SNPs through pairwise linkage disequilibrium (r2>0.80) in the MUC1, MUC2, MUC4, MUC5AC, MUC6, and B3GNT6 genes in a hospital-based case-control study of 1532 CRC cases and 1108 healthy controls from the Czech Republic. We also analyzed these SNPs in relation to overall survival and event-free survival in a subgroup of 672 patients. Among patients without distant metastasis at the time of diagnosis, two MUC4 SNPs, rs3107764 and rs842225, showed association with overall survival (HR 1.40, 95%CI 1.08-1.82, additive model, log-rank p = 0.004 and HR 0.64, 95%CI 0.42-0.99, recessive model, log-rank p = 0.01, respectively) and event-free survival (HR 1.31, 95%CI 1.03-1.68, log-rank p = 0.004 and HR 0.64, 95%CI 0.42-0.96, log-rank p = 0.006, respectively) after adjustment for age, sex and TNM stage. Our data suggest that genetic variation especially in the transmembrane mucin gene MUC4 may play a role in the survival of CRC and further studies are warranted. | ||
| 650 | 4 | |a 5' UTR | |
| 650 | 4 | |a Alleles | |
| 650 | 4 | |a Cancer detection and diagnosis | |
| 650 | 4 | |a Colorectal cancer | |
| 650 | 4 | |a Human genetics | |
| 650 | 4 | |a Metastasis | |
| 650 | 4 | |a Mucin | |
| 650 | 4 | |a Variant genotypes | |
| 700 | 1 | |a Catalano, Calogerina |d 1988- |e VerfasserIn |0 (DE-588)1178378616 |0 (DE-627)1049322088 |0 (DE-576)517757621 |4 aut | |
| 700 | 1 | |a Huhn, Stefanie |d 1982- |e VerfasserIn |0 (DE-588)1014984424 |0 (DE-627)705313190 |0 (DE-576)349876436 |4 aut | |
| 700 | 1 | |a Hemminki, Kari |d 1947- |e VerfasserIn |0 (DE-588)1150735872 |0 (DE-627)1010964402 |0 (DE-576)172043751 |4 aut | |
| 700 | 1 | |a Försti, Asta |e VerfasserIn |0 (DE-588)1155331672 |0 (DE-627)1017045755 |0 (DE-576)501623833 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t PLOS ONE |d San Francisco, California, US : PLOS, 2006 |g 14(2019,5) Artikel-Nummer e0216666, 13 Seiten |h Online-Ressource |w (DE-627)523574592 |w (DE-600)2267670-3 |w (DE-576)281331979 |x 1932-6203 |7 nnas |a Single nucleotide polymorphisms within MUC4 are associated with colorectal cancer survival |
| 773 | 1 | 8 | |g volume:14 |g year:2019 |g number:5 |g extent:13 |a Single nucleotide polymorphisms within MUC4 are associated with colorectal cancer survival |
| 856 | 4 | 0 | |u https://doi.org/10.1371/journal.pone.0216666 |x Verlag |x Resolving-System |3 Volltext |
| 856 | 4 | 0 | |u https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0216666 |x Verlag |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20190701 | ||
| 993 | |a Article | ||
| 994 | |a 2019 | ||
| 998 | |g 1155331672 |a Försti, Asta |m 1155331672:Försti, Asta |d 50000 |e 50000PF1155331672 |k 0/50000/ |p 12 |y j | ||
| 998 | |g 1150735872 |a Hemminki, Kari |m 1150735872:Hemminki, Kari |d 50000 |e 50000PH1150735872 |k 0/50000/ |p 10 | ||
| 998 | |g 1014984424 |a Huhn, Stefanie |m 1014984424:Huhn, Stefanie |d 910000 |d 910100 |e 910000PH1014984424 |e 910100PH1014984424 |k 0/910000/ |k 1/910000/910100/ |p 3 | ||
| 998 | |g 1178378616 |a Catalano, Calogerina |m 1178378616:Catalano, Calogerina |d 910000 |d 910100 |e 910000PC1178378616 |e 910100PC1178378616 |k 0/910000/ |k 1/910000/910100/ |p 2 | ||
| 999 | |a KXP-PPN1668144115 |e 3490319346 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"type":{"media":"Online-Ressource","bibl":"article-journal"},"person":[{"role":"aut","display":"Lu, Shun","roleDisplay":"VerfasserIn","given":"Shun","family":"Lu"},{"family":"Catalano","roleDisplay":"VerfasserIn","given":"Calogerina","display":"Catalano, Calogerina","role":"aut"},{"role":"aut","roleDisplay":"VerfasserIn","display":"Huhn, Stefanie","given":"Stefanie","family":"Huhn"},{"given":"Kari","roleDisplay":"VerfasserIn","display":"Hemminki, Kari","family":"Hemminki","role":"aut"},{"role":"aut","family":"Försti","display":"Försti, Asta","roleDisplay":"VerfasserIn","given":"Asta"}],"title":[{"title_sort":"Single nucleotide polymorphisms within MUC4 are associated with colorectal cancer survival","title":"Single nucleotide polymorphisms within MUC4 are associated with colorectal cancer survival"}],"id":{"eki":["1668144115"],"doi":["10.1371/journal.pone.0216666"]},"recId":"1668144115","name":{"displayForm":["Shun Lu, Calogerina Catalano, Stefanie Huhn, Barbara Pardini, Linda Partu, Veronika Vymetalkova, Ludmila Vodickova, Miroslav Levy, Thomas Buchler, Kari Hemminki, Pavel Vodicka, Asta Försti"]},"physDesc":[{"extent":"13 S."}],"relHost":[{"corporate":[{"roleDisplay":"Herausgebendes Organ","display":"Public Library of Science","role":"isb"}],"origin":[{"dateIssuedKey":"2006","dateIssuedDisp":"2006-","publisher":"PLOS ; PLoS","publisherPlace":"San Francisco, California, US ; Lawrence, Kan."}],"physDesc":[{"extent":"Online-Ressource"}],"note":["Schreibweise des Titels bis 2012: PLoS ONE","Gesehen am 20.03.19"],"language":["eng"],"disp":"Single nucleotide polymorphisms within MUC4 are associated with colorectal cancer survivalPLOS ONE","recId":"523574592","id":{"eki":["523574592"],"zdb":["2267670-3"],"issn":["1932-6203"]},"name":{"displayForm":["Public Library of Science"]},"pubHistory":["1.2006 -"],"part":{"year":"2019","volume":"14","extent":"13","text":"14(2019,5) Artikel-Nummer e0216666, 13 Seiten","issue":"5"},"type":{"bibl":"periodical","media":"Online-Ressource"},"title":[{"title":"PLOS ONE","title_sort":"PLOS ONE"}]}],"note":["Gesehen am 01.07.2019"],"language":["eng"],"origin":[{"dateIssuedKey":"2019","dateIssuedDisp":"May 15, 2019"}]} | ||
| SRT | |a LUSHUNCATASINGLENUCL1520 | ||