Model-based identification of TNFα-induced IKKβ-mediated and I[kappa]Bα-mediated regulation of NF[kappa]B signal transduction as a tool to quantify the impact of drug-induced liver injury compounds

Drug-induced liver injury (DILI) is one of the most important obstacles during drug development. More than 1000 drugs have been identified to damage the liver, but the current test systems are poor in predicting DILI. A team of cell biologists, theoretical physicists, and clinical pharmacologists co...

Full description

Bibliographic Details

Main Authors:	Oppelt, Angela (Author) , Kaschek, Daniel (Author) , Huppelschoten, Suzanna (Author) , Sison-Young, Rowena (Author) , Zhang, Fang (Author) , Buck-Wiese, Marie (Author) , Herrmann, Franziska (Author) , Malkusch, Sebastian (Author) , Krüger, Carmen L. (Author) , Meub, Mara (Author) , Merkt, Benjamin (Author) , Zimmermann, Lea (Author) , Schofield, Amy (Author) , Jones, Robert P. (Author) , Malik, Hassan (Author) , Schilling, Marcel (Author) , Heilemann, Mike (Author) , Water, Bob van de (Author) , Goldring, Christopher E. (Author) , Park, B. Kevin (Author) , Timmer, Jens (Author) , Klingmüller, Ursula (Author)
Format:	Article (Journal)
Language:	English
Published:	11 June 2018
In:	npj Systems biology and applications Year: 2018, Volume: 4, Issue: 1
ISSN:	2056-7189
DOI:	10.1038/s41540-018-0058-z
Online Access:	Verlag, Volltext: https://doi.org/10.1038/s41540-018-0058-z Verlag, Volltext: https://www.nature.com/articles/s41540-018-0058-z
Author Notes:	Angela Oppelt, Daniel Kaschek, Suzanna Huppelschoten, Rowena Sison-Young, Fang Zhang, Marie Buck-Wiese, Franziska Herrmann, Sebastian Malkusch, Carmen L. Krüger, Mara Meub, Benjamin Merkt, Lea Zimmermann, Amy Schofield, Robert P. Jones, Hassan Malik, Marcel Schilling, Mike Heilemann, Bob van de Water, Christopher E. Goldring, B. Kevin Park, Jens Timmer and Ursula Klingmüller