Leda-1/Pianp is targeted to the basolateral plasma membrane by a distinct intracellular juxtamembrane region and modulates barrier properties and E-Cadherin processing
Leda-1/Pianp is a type-I transmembrane protein which is sorted to the basolateral membrane domain of polarized epithelial cells. Here, we investigated trafficking mechanisms and functions of Leda-1/Pianp in MDCK and MCF-7 cells. Basolateral sorting and posttranslational modifications depended on the...
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| Main Authors: | , , , , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
20 May 2016
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| In: |
Biochemical and biophysical research communications
Year: 2016, Volume: 475, Issue: 4, Pages: 342-349 |
| ISSN: | 1090-2104 |
| DOI: | 10.1016/j.bbrc.2016.05.092 |
| Online Access: | Verlag, Volltext: https://doi.org/10.1016/j.bbrc.2016.05.092 Verlag, Volltext: http://www.sciencedirect.com/science/article/pii/S0006291X16308002 
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| Author Notes: | Konstantin Evdokimov, Siladitta Biswas, Kai Schledzewski, Manuel Winkler, Christian Gorzelanny, Stefan W. Schneider, Sergij Goerdt, Cyrill Géraud |
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| 520 | |a Leda-1/Pianp is a type-I transmembrane protein which is sorted to the basolateral membrane domain of polarized epithelial cells. Here, we investigated trafficking mechanisms and functions of Leda-1/Pianp in MDCK and MCF-7 cells. Basolateral sorting and posttranslational modifications depended on the intracellular juxtamembrane region. Functionally, Leda-1/Pianp increased the transepithelial electrical resistance generated by a polarized cell sheet. Furthermore, resistance to junctional destabilization by tumor cells was enhanced by Leda-1/Pianp indicating increased stability and tightness of intercellular junctions. While Claudin 1 and 4 expression and activities of small GTPases were not affected, γ-Secretase-mediated cleavage of E-Cadherin was attenuated by Leda-1/Pianp. Regulation of proteolytic processing is thus a molecular mechanism by which Leda-1/Pianp can affect junctional integrity and function. | ||
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