Guanylate-binding proteins 2 and 5 exert broad antiviral activity by inhibiting furin-mediated processing of viral envelope proteins
Summary - Guanylate-binding protein (GBP) 5 is an interferon (IFN)-inducible cellular factor reducing HIV-1 infectivity by an incompletely understood mechanism. Here, we show that this activity is shared by GBP2, but not by other members of the human GBP family. GBP2/5 decrease the activity of the c...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
14 May 2019
|
| In: |
Cell reports
Year: 2019, Volume: 27, Issue: 7, Pages: 2092-2104 |
| ISSN: | 2211-1247 |
| DOI: | 10.1016/j.celrep.2019.04.063 |
| Online Access: | Verlag, Volltext: https://doi.org/10.1016/j.celrep.2019.04.063 Verlag, Volltext: http://www.sciencedirect.com/science/article/pii/S2211124719305364 
|
| Author Notes: | Elisabeth Braun, Dominik Hotter, Lennart Koepke, Fabian Zech, Rüdiger Groß, Konstantin M.J. Sparrer, Janis A. Müller, Christian K. Pfaller, Elena Heusinger, Rebecka Wombacher, Kathrin Sutter, Ulf Dittmer, Michael Winkler, Graham Simmons, Martin R. Jakobsen, Karl-Klaus Conzelmann, Stefan Pöhlmann, Jan Münch, Oliver T. Fackler, Frank Kirchhoff, and Daniel Sauter |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1668710692 | ||
| 003 | DE-627 | ||
| 005 | 20240323101234.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 190705s2019 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/j.celrep.2019.04.063 |2 doi | |
| 035 | |a (DE-627)1668710692 | ||
| 035 | |a (DE-599)KXP1668710692 | ||
| 035 | |a (OCoLC)1341232251 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 32 |2 sdnb | ||
| 100 | 1 | |a Braun, Elisabeth |e VerfasserIn |0 (DE-588)1189952882 |0 (DE-627)1668710978 |4 aut | |
| 245 | 1 | 0 | |a Guanylate-binding proteins 2 and 5 exert broad antiviral activity by inhibiting furin-mediated processing of viral envelope proteins |c Elisabeth Braun, Dominik Hotter, Lennart Koepke, Fabian Zech, Rüdiger Groß, Konstantin M.J. Sparrer, Janis A. Müller, Christian K. Pfaller, Elena Heusinger, Rebecka Wombacher, Kathrin Sutter, Ulf Dittmer, Michael Winkler, Graham Simmons, Martin R. Jakobsen, Karl-Klaus Conzelmann, Stefan Pöhlmann, Jan Münch, Oliver T. Fackler, Frank Kirchhoff, and Daniel Sauter |
| 264 | 1 | |c 14 May 2019 | |
| 300 | |a 23 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Elisabeth Braun and Dominik Hotter contributed equally | ||
| 500 | |a The article ends with page 2104.e10 | ||
| 500 | |a Gesehen am 05.07.2019 | ||
| 520 | |a Summary - Guanylate-binding protein (GBP) 5 is an interferon (IFN)-inducible cellular factor reducing HIV-1 infectivity by an incompletely understood mechanism. Here, we show that this activity is shared by GBP2, but not by other members of the human GBP family. GBP2/5 decrease the activity of the cellular proprotein convertase furin, which mediates conversion of the HIV-1 envelope protein (Env) precursor gp160 into mature gp120 and gp41. Because this process primes HIV-1 Env for membrane fusion, viral particles produced in the presence of GBP2/5 are poorly infectious due to increased incorporation of non-functional gp160. Furin activity is critical for the processing of envelope glycoproteins of many viral pathogens. Consistently, GBP2/5 also inhibit Zika, measles, and influenza A virus replication and decrease infectivity of viral particles carrying glycoproteins of Marburg and murine leukemia viruses. Collectively, our results show that GPB2/5 exert broad antiviral activity by suppressing the activity of the virus-dependency factor furin. | ||
| 650 | 4 | |a furin | |
| 650 | 4 | |a GBPs | |
| 650 | 4 | |a HIV | |
| 650 | 4 | |a influenza A virus | |
| 650 | 4 | |a measles virus | |
| 650 | 4 | |a restriction factor | |
| 650 | 4 | |a viral envelope proteins | |
| 650 | 4 | |a Zika virus | |
| 700 | 1 | |a Hotter, Dominik |e VerfasserIn |0 (DE-588)1121525768 |0 (DE-627)874322057 |0 (DE-576)479784809 |4 aut | |
| 700 | 1 | |a Wombacher, Rebecka |d 1988- |e VerfasserIn |0 (DE-588)1142572943 |0 (DE-627)1002270391 |0 (DE-576)494862335 |4 aut | |
| 700 | 1 | |a Fackler, Oliver Till |e VerfasserIn |0 (DE-588)1026682444 |0 (DE-627)727057391 |0 (DE-576)178094501 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Cell reports |d Maryland Heights, MO : Cell Press, 2012 |g 27(2019), 7, Seite 2092-2104 |h Online-Ressource |w (DE-627)684964562 |w (DE-600)2649101-1 |w (DE-576)358411572 |x 2211-1247 |7 nnas |a Guanylate-binding proteins 2 and 5 exert broad antiviral activity by inhibiting furin-mediated processing of viral envelope proteins |
| 773 | 1 | 8 | |g volume:27 |g year:2019 |g number:7 |g pages:2092-2104 |g extent:23 |a Guanylate-binding proteins 2 and 5 exert broad antiviral activity by inhibiting furin-mediated processing of viral envelope proteins |
| 856 | 4 | 0 | |u https://doi.org/10.1016/j.celrep.2019.04.063 |x Verlag |x Resolving-System |3 Volltext |
| 856 | 4 | 0 | |u http://www.sciencedirect.com/science/article/pii/S2211124719305364 |x Verlag |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20190705 | ||
| 993 | |a Article | ||
| 994 | |a 2019 | ||
| 998 | |g 1026682444 |a Fackler, Oliver Till |m 1026682444:Fackler, Oliver Till |d 910000 |d 911700 |e 910000PF1026682444 |e 911700PF1026682444 |k 0/910000/ |k 1/910000/911700/ |p 19 | ||
| 998 | |g 1142572943 |a Wombacher, Rebecka |m 1142572943:Wombacher, Rebecka |d 910000 |d 911700 |e 910000PW1142572943 |e 911700PW1142572943 |k 0/910000/ |k 1/910000/911700/ |p 10 | ||
| 999 | |a KXP-PPN1668710692 |e 3491396697 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"title":[{"title_sort":"Guanylate-binding proteins 2 and 5 exert broad antiviral activity by inhibiting furin-mediated processing of viral envelope proteins","title":"Guanylate-binding proteins 2 and 5 exert broad antiviral activity by inhibiting furin-mediated processing of viral envelope proteins"}],"physDesc":[{"extent":"23 S."}],"relHost":[{"title":[{"title_sort":"Cell reports","title":"Cell reports"}],"physDesc":[{"extent":"Online-Ressource"}],"part":{"volume":"27","text":"27(2019), 7, Seite 2092-2104","extent":"23","issue":"7","year":"2019","pages":"2092-2104"},"language":["eng"],"pubHistory":["1.2012 -"],"origin":[{"publisher":"Cell Press ; Elsevier","dateIssuedDisp":"2012-","dateIssuedKey":"2012","publisherPlace":"Maryland Heights, MO ; [New York, NY]"}],"disp":"Guanylate-binding proteins 2 and 5 exert broad antiviral activity by inhibiting furin-mediated processing of viral envelope proteinsCell reports","type":{"media":"Online-Ressource","bibl":"periodical"},"recId":"684964562","id":{"zdb":["2649101-1"],"eki":["684964562"],"issn":["2211-1247"]}}],"origin":[{"dateIssuedKey":"2019","dateIssuedDisp":"14 May 2019"}],"name":{"displayForm":["Elisabeth Braun, Dominik Hotter, Lennart Koepke, Fabian Zech, Rüdiger Groß, Konstantin M.J. Sparrer, Janis A. Müller, Christian K. Pfaller, Elena Heusinger, Rebecka Wombacher, Kathrin Sutter, Ulf Dittmer, Michael Winkler, Graham Simmons, Martin R. Jakobsen, Karl-Klaus Conzelmann, Stefan Pöhlmann, Jan Münch, Oliver T. Fackler, Frank Kirchhoff, and Daniel Sauter"]},"type":{"bibl":"article-journal","media":"Online-Ressource"},"id":{"eki":["1668710692"],"doi":["10.1016/j.celrep.2019.04.063"]},"recId":"1668710692","person":[{"given":"Elisabeth","display":"Braun, Elisabeth","role":"aut","family":"Braun"},{"given":"Dominik","display":"Hotter, Dominik","family":"Hotter","role":"aut"},{"given":"Rebecka","display":"Wombacher, Rebecka","family":"Wombacher","role":"aut"},{"display":"Fackler, Oliver Till","family":"Fackler","role":"aut","given":"Oliver Till"}],"language":["eng"],"note":["Elisabeth Braun and Dominik Hotter contributed equally","The article ends with page 2104.e10","Gesehen am 05.07.2019"]} | ||
| SRT | |a BRAUNELISAGUANYLATEB1420 | ||