High seroprevalence of antibodies against Kaposi’s sarcoma-associated herpesvirus (KSHV) among HIV-1-infected children and adolescents in a non-endemic population
Human herpesvirus-8 (HHV-8) is the etiological agent of Kaposi’s sarcoma (KS), which primarily affects human immunodeficiency virus (HIV)-infected adults with advanced immunodeficiency. Currently, only limited prevalence data for HHV-8 infection in HIV-infected children living in non-endemic areas a...
Gespeichert in:
| Hauptverfasser: | , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
30 May 2016
|
| In: |
Medical microbiology and immunology
Year: 2016, Jahrgang: 205, Heft: 5, Pages: 425-434 |
| ISSN: | 1432-1831 |
| DOI: | 10.1007/s00430-016-0458-x |
| Online-Zugang: | Verlag, Volltext: https://doi.org/10.1007/s00430-016-0458-x
|
| Verfasserangaben: | Cornelia Feiterna-Sperling, Christoph Königs, Gundula Notheis, Bernd Buchholz, Renate Krüger, Katharina Weizsäcker, Josef Eberle, Nikola Hanhoff, Barbara Gärtner, Harald Heider, Detlev H. Krüger, Jörg Hofmann |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1668734095 | ||
| 003 | DE-627 | ||
| 005 | 20230427221521.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 190708s2016 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1007/s00430-016-0458-x |2 doi | |
| 035 | |a (DE-627)1668734095 | ||
| 035 | |a (DE-599)KXP1668734095 | ||
| 035 | |a (OCoLC)1341233148 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Feiterna-Sperling, Cornelia |e VerfasserIn |0 (DE-588)1190051265 |0 (DE-627)166873401X |4 aut | |
| 245 | 1 | 0 | |a High seroprevalence of antibodies against Kaposi’s sarcoma-associated herpesvirus (KSHV) among HIV-1-infected children and adolescents in a non-endemic population |c Cornelia Feiterna-Sperling, Christoph Königs, Gundula Notheis, Bernd Buchholz, Renate Krüger, Katharina Weizsäcker, Josef Eberle, Nikola Hanhoff, Barbara Gärtner, Harald Heider, Detlev H. Krüger, Jörg Hofmann |
| 264 | 1 | |c 30 May 2016 | |
| 300 | |a 10 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 08.07.2019 | ||
| 520 | |a Human herpesvirus-8 (HHV-8) is the etiological agent of Kaposi’s sarcoma (KS), which primarily affects human immunodeficiency virus (HIV)-infected adults with advanced immunodeficiency. Currently, only limited prevalence data for HHV-8 infection in HIV-infected children living in non-endemic areas are available. This multicenter cross-sectional study was conducted in four university hospitals in Germany specializing in pediatric HIV care. Stored serum specimens obtained from 207 vertically HIV-1-infected children and adolescents were tested for antibodies against lytic and latent HHV-8 antigens. Logistic regression was used to assess independent risk factors associated with HHV-8 seropositivity. The overall HHV-8 seroprevalence was 24.6 % (n = 51/207) without significant differences related to sex, age, or ethnicity. In univariate analysis, HHV-8 seropositivity was significantly associated with a child having being born outside Germany, maternal origin from sub-Saharan Africa, a history of breastfeeding, CDC immunologic category 3, and deferred initiation of antiretroviral therapy (>24 months of age). In multivariate analysis, a child’s birth outside Germany was the only significant risk factor for HHV-8 seropositivity (odds ratio 3.98; 95 % confidence interval 1.27-12.42). HHV-8-associated malignancies were uncommon; only one patient had a history of KS. Serum specimen of vertically HIV-infected children and adolescents living in Germany showed a high HHV-8 seroprevalence. These findings suggest that primary HHV-8 infection—a risk factor for KS and other HHV-8-associated malignancies—occurs early in life. Thus, management of perinatally HIV-infected children should include testing for HHV-8 coinfection and should consider future risks of HHV-8-associated malignancies. | ||
| 650 | 4 | |a HHV-8 | |
| 650 | 4 | |a HIV-1 | |
| 650 | 4 | |a Human herpesvirus-8 | |
| 650 | 4 | |a Kaposi’s sarcoma | |
| 650 | 4 | |a Kaposi’s sarcoma-associated herpesvirus | |
| 650 | 4 | |a KSHV | |
| 650 | 4 | |a Pediatric patients | |
| 700 | 1 | |a Buchholz, Bernd |d 1960- |e VerfasserIn |0 (DE-588)1069569372 |0 (DE-627)822025116 |0 (DE-576)429275161 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Medical microbiology and immunology |d Berlin : Springer, 1972 |g 205(2016), 5, Seite 425-434 |h Online-Ressource |w (DE-627)254630871 |w (DE-600)1462140-X |w (DE-576)074529765 |x 1432-1831 |7 nnas |a High seroprevalence of antibodies against Kaposi’s sarcoma-associated herpesvirus (KSHV) among HIV-1-infected children and adolescents in a non-endemic population |
| 773 | 1 | 8 | |g volume:205 |g year:2016 |g number:5 |g pages:425-434 |g extent:10 |a High seroprevalence of antibodies against Kaposi’s sarcoma-associated herpesvirus (KSHV) among HIV-1-infected children and adolescents in a non-endemic population |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s00430-016-0458-x |x Verlag |x Resolving-System |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20190708 | ||
| 993 | |a Article | ||
| 994 | |a 2016 | ||
| 998 | |g 1069569372 |a Buchholz, Bernd |m 1069569372:Buchholz, Bernd |d 60000 |e 60000PB1069569372 |k 0/60000/ |p 4 | ||
| 999 | |a KXP-PPN1668734095 |e 3491877792 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"title":[{"title":"High seroprevalence of antibodies against Kaposi’s sarcoma-associated herpesvirus (KSHV) among HIV-1-infected children and adolescents in a non-endemic population","title_sort":"High seroprevalence of antibodies against Kaposi’s sarcoma-associated herpesvirus (KSHV) among HIV-1-infected children and adolescents in a non-endemic population"}],"person":[{"given":"Cornelia","family":"Feiterna-Sperling","role":"aut","display":"Feiterna-Sperling, Cornelia","roleDisplay":"VerfasserIn"},{"display":"Buchholz, Bernd","roleDisplay":"VerfasserIn","role":"aut","family":"Buchholz","given":"Bernd"}],"recId":"1668734095","language":["eng"],"type":{"media":"Online-Ressource","bibl":"article-journal"},"note":["Gesehen am 08.07.2019"],"id":{"eki":["1668734095"],"doi":["10.1007/s00430-016-0458-x"]},"origin":[{"dateIssuedDisp":"30 May 2016","dateIssuedKey":"2016"}],"name":{"displayForm":["Cornelia Feiterna-Sperling, Christoph Königs, Gundula Notheis, Bernd Buchholz, Renate Krüger, Katharina Weizsäcker, Josef Eberle, Nikola Hanhoff, Barbara Gärtner, Harald Heider, Detlev H. Krüger, Jörg Hofmann"]},"relHost":[{"title":[{"title":"Medical microbiology and immunology","title_sort":"Medical microbiology and immunology"}],"language":["eng"],"recId":"254630871","disp":"High seroprevalence of antibodies against Kaposi’s sarcoma-associated herpesvirus (KSHV) among HIV-1-infected children and adolescents in a non-endemic populationMedical microbiology and immunology","note":["Erscheint unregelmäßig","Gesehen am 04.06.2024"],"type":{"media":"Online-Ressource","bibl":"periodical"},"part":{"issue":"5","pages":"425-434","year":"2016","extent":"10","text":"205(2016), 5, Seite 425-434","volume":"205"},"pubHistory":["Volume 157 (1971/1972)-"],"id":{"eki":["254630871"],"zdb":["1462140-X"],"issn":["1432-1831"]},"origin":[{"dateIssuedDisp":"1972-","publisher":"Springer ; Springer","dateIssuedKey":"1972","publisherPlace":"Berlin ; Heidelberg ; Berlin ; Heidelberg ; New York, NY"}],"physDesc":[{"extent":"Online-Ressource"}]}],"physDesc":[{"extent":"10 S."}]} | ||
| SRT | |a FEITERNASPHIGHSEROPR3020 | ||