Multiple roles of NF1 in the melanocyte lineage
NF1 is a tumour suppressor gene, germline mutations of which lead to neurofibromatosis type 1 syndrome. Patients develop benign tumours from several types of cells including neural crest-derived cells. NF1 somatic mutations also occur in 15% of sporadic melanoma, a cancer originating from melanocyte...
Gespeichert in:
| Hauptverfasser: | , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
7 May 2016
|
| In: |
Pigment cell & melanoma research
Year: 2016, Jahrgang: 29, Heft: 4, Pages: 417-425 |
| ISSN: | 1755-148X |
| DOI: | 10.1111/pcmr.12488 |
| Online-Zugang: | Verlag, Volltext: https://doi.org/10.1111/pcmr.12488 Verlag, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1111/pcmr.12488 
|
| Verfasserangaben: | Lionel Larribère and Jochen Utikal |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1668784718 | ||
| 003 | DE-627 | ||
| 005 | 20220816185214.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 190708s2016 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1111/pcmr.12488 |2 doi | |
| 035 | |a (DE-627)1668784718 | ||
| 035 | |a (DE-599)KXP1668784718 | ||
| 035 | |a (OCoLC)1341233248 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Larribere, Lionel |e VerfasserIn |0 (DE-588)1118655079 |0 (DE-627)872164837 |0 (DE-576)479578648 |4 aut | |
| 245 | 1 | 0 | |a Multiple roles of NF1 in the melanocyte lineage |c Lionel Larribère and Jochen Utikal |
| 264 | 1 | |c 7 May 2016 | |
| 300 | |a 9 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 08.07.2019 | ||
| 520 | |a NF1 is a tumour suppressor gene, germline mutations of which lead to neurofibromatosis type 1 syndrome. Patients develop benign tumours from several types of cells including neural crest-derived cells. NF1 somatic mutations also occur in 15% of sporadic melanoma, a cancer originating from melanocytes. Evidence now suggests the involvement of NF1 mutations in melanoma resistance to targeted therapies. Although NF1 is ubiquitously expressed, genetic links between NF1 and genes involved in melanocyte biology have been described, implying the lineage-specific mechanisms. In this review, we summarize and discuss the latest advances related to the roles of NF1 in melanocyte biology and in cutaneous melanoma. | ||
| 650 | 4 | |a NF1 | |
| 650 | 4 | |a cancer | |
| 650 | 4 | |a melanocyte | |
| 650 | 4 | |a melanoma | |
| 650 | 4 | |a neurofibromatosis type 1 | |
| 700 | 1 | |a Utikal, Jochen |d 1974- |e VerfasserIn |0 (DE-588)1026463750 |0 (DE-627)726765015 |0 (DE-576)371816580 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Pigment cell & melanoma research |d Oxford [u.a.] : Wiley-Blackwell, 2008 |g 29(2016), 4, Seite 417-425 |h Online-Ressource |w (DE-627)566015110 |w (DE-600)2425880-5 |w (DE-576)281507899 |x 1755-148X |7 nnas |a Multiple roles of NF1 in the melanocyte lineage |
| 773 | 1 | 8 | |g volume:29 |g year:2016 |g number:4 |g pages:417-425 |g extent:9 |a Multiple roles of NF1 in the melanocyte lineage |
| 856 | 4 | 0 | |u https://doi.org/10.1111/pcmr.12488 |x Verlag |x Resolving-System |3 Volltext |
| 856 | 4 | 0 | |u https://onlinelibrary.wiley.com/doi/abs/10.1111/pcmr.12488 |x Verlag |x Resolving-System |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20190708 | ||
| 993 | |a Article | ||
| 994 | |a 2016 | ||
| 998 | |g 1026463750 |a Utikal, Jochen |m 1026463750:Utikal, Jochen |d 60000 |e 60000PU1026463750 |k 0/60000/ |p 2 |y j | ||
| 999 | |a KXP-PPN1668784718 |e 3491987385 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"language":["eng"],"origin":[{"dateIssuedDisp":"7 May 2016","dateIssuedKey":"2016"}],"type":{"bibl":"article-journal","media":"Online-Ressource"},"name":{"displayForm":["Lionel Larribère and Jochen Utikal"]},"person":[{"roleDisplay":"VerfasserIn","family":"Larribere","given":"Lionel","display":"Larribere, Lionel","role":"aut"},{"family":"Utikal","roleDisplay":"VerfasserIn","role":"aut","display":"Utikal, Jochen","given":"Jochen"}],"physDesc":[{"extent":"9 S."}],"relHost":[{"title":[{"subtitle":"the official journal of the International Federation of Pigment Cell Societies and the Society for Melanoma Research","title_sort":"Pigment cell & melanoma research","title":"Pigment cell & melanoma research"}],"id":{"doi":["10.1111/(ISSN)1755-148X"],"eki":["566015110"],"zdb":["2425880-5"],"issn":["1755-148X"]},"disp":"Multiple roles of NF1 in the melanocyte lineagePigment cell & melanoma research","note":["Gesehen am 05.04.14"],"physDesc":[{"extent":"Online-Ressource"}],"part":{"pages":"417-425","extent":"9","year":"2016","volume":"29","issue":"4","text":"29(2016), 4, Seite 417-425"},"origin":[{"publisher":"Wiley-Blackwell","dateIssuedKey":"2008","publisherPlace":"Oxford [u.a.]","dateIssuedDisp":"2008-"}],"type":{"bibl":"periodical","media":"Online-Ressource"},"language":["eng"],"pubHistory":["21.2008 -"],"recId":"566015110"}],"id":{"eki":["1668784718"],"doi":["10.1111/pcmr.12488"]},"title":[{"title":"Multiple roles of NF1 in the melanocyte lineage","title_sort":"Multiple roles of NF1 in the melanocyte lineage"}],"recId":"1668784718","note":["Gesehen am 08.07.2019"]} | ||
| SRT | |a LARRIBERELMULTIPLERO7201 | ||