TelomereHunter: in silico estimation of telomere content and composition from cancer genomes

Establishment of telomere maintenance mechanisms is a universal step in tumor development to achieve replicative immortality. These processes leave molecular footprints in cancer genomes in the form of altered telomere content and aberrations in telomere composition. To retrieve these telomere chara...

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Main Authors:	Feuerbach, Lars (Author) , Sieverling, Lina Katharine (Author) , Deeg, Katharina (Author) , Hutter, Barbara (Author) , Buchhalter, Ivo (Author) , Mughal, Sadaf Shabbir (Author) , Chudasama, Priya (Author) , Glimm, Hanno (Author) , Scholl, Claudia (Author) , Lichter, Peter (Author) , Fröhling, Stefan (Author) , Pfister, Stefan (Author) , Jones, David T. W. (Author) , Rippe, Karsten (Author) , Brors, Benedikt (Author)
Format:	Article (Journal)
Language:	English
Published:	28 May 2019
In:	BMC bioinformatics Year: 2019, Volume: 20
ISSN:	1471-2105
DOI:	10.1186/s12859-019-2851-0
Online Access:	Verlag, Volltext: https://doi.org/10.1186/s12859-019-2851-0
Author Notes:	Lars Feuerbach, Lina Sieverling, Katharina I. Deeg, Philip Ginsbach, Barbara Hutter, Ivo Buchhalter, Paul A. Northcott, Sadaf S. Mughal, Priya Chudasama, Hanno Glimm, Claudia Scholl, Peter Lichter, Stefan Fröhling, Stefan M. Pfister, David T.W. Jones, Karsten Rippe, Benedikt Brors

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520			\|a Establishment of telomere maintenance mechanisms is a universal step in tumor development to achieve replicative immortality. These processes leave molecular footprints in cancer genomes in the form of altered telomere content and aberrations in telomere composition. To retrieve these telomere characteristics from high-throughput sequencing data the available computational approaches need to be extended and optimized to fully exploit the information provided by large scale cancer genome data sets.
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TelomereHunter: in silico estimation of telomere content and composition from cancer genomes

MARC

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