The cellular antiviral restriction factor tetherin does not inhibit poxviral replication
Interferon-stimulated genes fulfill innate antiviral effector functions. Among them, tetherin (THN) blocks the release of many enveloped viruses from infected cells. Vaccinia virus (VACV) encodes immune modulators interfering with antiviral host responses. Therefore, it was tempting to study a poten...
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| Main Authors: | , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
2012
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| In: |
Journal of virology
Year: 2011, Volume: 86, Issue: 3, Pages: 1893-1896 |
| ISSN: | 1098-5514 |
| DOI: | 10.1128/JVI.05198-11 |
| Online Access: | Verlag, Volltext: http://dx.doi.org/10.1128/JVI.05198-11
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| Author Notes: | Katja Sliva, Theresa Resch, Benjamin Kraus, Christine Goffinet, Oliver T. Keppler, and Barbara S. Schnierle |
| Summary: | Interferon-stimulated genes fulfill innate antiviral effector functions. Among them, tetherin (THN) blocks the release of many enveloped viruses from infected cells. Vaccinia virus (VACV) encodes immune modulators interfering with antiviral host responses. Therefore, it was tempting to study a potential VACV-THN interaction. Remarkably, THN expression did not inhibit VACV release and replication. VACV infection did not diminish THN surface levels or impair its function on retroviral release. This suggests that THN is unable to restrict VACV replication. |
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| Item Description: | Published ahead of print 16 November 2011 Gesehen am 09.07.2019 |
| Physical Description: | Online Resource |
| ISSN: | 1098-5514 |
| DOI: | 10.1128/JVI.05198-11 |