Immune genes are primed for robust transcription by proximal long noncoding RNAs located in nuclear compartments
This study shows that immune-related genes are primed for transcription by proximal lncRNAs. One such lncRNA, UMLILO, directs the WDR5-MLL1 complex to CXCL chemokine promoters, facilitating H3K4me3 deposition.
Gespeichert in:
| Hauptverfasser: | , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
2019
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| In: |
Nature genetics
Year: 2018, Jahrgang: 51, Heft: 1, Pages: 138-150 |
| ISSN: | 1546-1718 |
| DOI: | 10.1038/s41588-018-0298-2 |
| Online-Zugang: | Verlag, Volltext: https://doi.org/10.1038/s41588-018-0298-2 Verlag, Volltext: https://www.nature.com/articles/s41588-018-0298-2 
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| Verfasserangaben: | Stephanie Fanucchi, Ezio T. Fok, Emiliano Dalla, Youtaro Shibayama, Kathleen Börner, Erin Y. Chang, Stoyan Stoychev, Maxim Imakaev, Dirk Grimm, Kevin C. Wang, Guoliang Li, Wing-Kin Sung and Musa M. Mhlanga |
| Zusammenfassung: | This study shows that immune-related genes are primed for transcription by proximal lncRNAs. One such lncRNA, UMLILO, directs the WDR5-MLL1 complex to CXCL chemokine promoters, facilitating H3K4me3 deposition. |
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| Beschreibung: | Published online: 10 December 2018 Gesehen am 10.07.2019 |
| Beschreibung: | Online Resource |
| ISSN: | 1546-1718 |
| DOI: | 10.1038/s41588-018-0298-2 |