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Backbone modifications in peptidic inhibitors of flaviviral proteases

The NS2B-NS3 protease is a promising target for the development of drugs against dengue virus (DENV), West Nile virus (WNV) and related flaviviruses. We report the systematic variation of the peptide backbone of the two lead compounds Bz-Arg-Lys-d-Phg-NH2 and Bz-Arg-Lys-d-Phg(OBn)-NH2. While inhibit...

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Hauptverfasser: Jakob, Alexander (VerfasserIn) , Sundermann, Tom R. (VerfasserIn) , Klein, Christian D. (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: August 2019
In: Bioorganic & medicinal chemistry letters
Year: 2019, Jahrgang: 29, Heft: 15, Pages: 1913-1917
ISSN:1464-3405
DOI:10.1016/j.bmcl.2019.05.054
Online-Zugang:Verlag, Volltext: https://doi.org/10.1016/j.bmcl.2019.05.054
Verlag, Volltext: http://www.sciencedirect.com/science/article/pii/S0960894X19303609
Volltext
Verfasserangaben:Alexander K.M.H. Jakob, Tom R. Sundermann, Christian D. Klein

MARC

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