Expression of the p53 inhibitors MDM2 and MDM4 as outcome predictor in muscle-invasive bladder cancer
Aim: To evaluate the prognostic role of the p53-upstream inhibitors MDM2, MDM4 and its splice variant MDM4-S in patients undergoing radical cystectomy (RC) for muscle-invasive bladder cancer (MIBC). Materials and Methods: mRNA Expression levels of MDM2, MDM4 and MDM4-S were assessed by quantitative...
Gespeichert in:
| Hauptverfasser: | , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
October 2016
|
| In: |
Anticancer research
Year: 2016, Jahrgang: 36, Heft: 10, Pages: 5205-5213 |
| ISSN: | 1791-7530 |
| DOI: | undefined |
| Online-Zugang: | Verlag, Volltext: https://doi.org/undefined Verlag, Volltext: http://ar.iiarjournals.org/content/36/10/5205 
|
| Verfasserangaben: | Maximilian Christian Kriegmair, Matthias Balk, Ralph Wirtz, Annette Steidler, Cleo-Aron Weis, Johannes Breyer, Arndt Hartmann, Christian Bolenz and Philipp Erben |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1668936372 | ||
| 003 | DE-627 | ||
| 005 | 20220816190427.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 190710s2016 xx |||||o 00| ||eng c | ||
| 035 | |a (DE-627)1668936372 | ||
| 035 | |a (DE-599)KXP1668936372 | ||
| 035 | |a (OCoLC)1341233387 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Kriegmair, Maximilian |d 1987- |e VerfasserIn |0 (DE-588)1049742745 |0 (DE-627)782573347 |0 (DE-576)403726840 |4 aut | |
| 245 | 1 | 0 | |a Expression of the p53 inhibitors MDM2 and MDM4 as outcome predictor in muscle-invasive bladder cancer |c Maximilian Christian Kriegmair, Matthias Balk, Ralph Wirtz, Annette Steidler, Cleo-Aron Weis, Johannes Breyer, Arndt Hartmann, Christian Bolenz and Philipp Erben |
| 264 | 1 | |c October 2016 | |
| 300 | |a 9 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 10.07.2019 | ||
| 520 | |a Aim: To evaluate the prognostic role of the p53-upstream inhibitors MDM2, MDM4 and its splice variant MDM4-S in patients undergoing radical cystectomy (RC) for muscle-invasive bladder cancer (MIBC). Materials and Methods: mRNA Expression levels of MDM2, MDM4 and MDM4-S were assessed by quantitative real-time polymerase chain reaction (qRT-PCR) in 75 RC samples. Logistic regression analyses identified predictors of recurrence-free (RFS) and cancer-specific survival (CSS). Results: High expression was found in 42% (MDM2), 27% (MDMD4) and 91% (MDM4-S) of tumor specimens. Increased MDM2 expression was significantly associated with higher tumor stage (p=0.05) and lymphovascular invasion (LVI) (p=0.041). In the univariate analysis, low MDM4 expression (hazard ratio (HR)=5.93; p=0.002; HR=3.00; p=0.047), but not MDM2 (HR=1.63; p=0.222; HR=1.59; p=0.27), were associated with RFS and CSS. In the multivariate analysis, the combination of low MDM4 and high MDM2 was significant for RFS and CSS (HR=14.9; p=0.001; HR=5.63; p=0.019). Conclusion: The combination of MDM2 and MDM4 expression is an independent predictor in patients undergoing RC for MIBC. | ||
| 650 | 4 | |a bladder cancer | |
| 650 | 4 | |a HDMX | |
| 650 | 4 | |a marker | |
| 650 | 4 | |a MDM2 | |
| 650 | 4 | |a prognosis | |
| 700 | 1 | |a Steidler, Annette |d 1965- |e VerfasserIn |0 (DE-588)1038074843 |0 (DE-627)756633761 |0 (DE-576)392092263 |4 aut | |
| 700 | 1 | |a Weis, Cleo-Aron Thias |d 1985- |e VerfasserIn |0 (DE-588)1062803752 |0 (DE-627)806961198 |0 (DE-576)42022730X |4 aut | |
| 700 | 1 | |a Erben, Philipp |d 1973- |e VerfasserIn |0 (DE-588)128501014 |0 (DE-627)373920997 |0 (DE-576)297181661 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Anticancer research |d Kapandriti, Attiki, Greece : International Institute of Anticancer Research, 2004 |g 36(2016), 10, Seite 5205-5213 |h Online-Ressource |w (DE-627)387478493 |w (DE-600)2145376-7 |w (DE-576)358408717 |x 1791-7530 |7 nnas |a Expression of the p53 inhibitors MDM2 and MDM4 as outcome predictor in muscle-invasive bladder cancer |
| 773 | 1 | 8 | |g volume:36 |g year:2016 |g number:10 |g pages:5205-5213 |g extent:9 |a Expression of the p53 inhibitors MDM2 and MDM4 as outcome predictor in muscle-invasive bladder cancer |
| 856 | 4 | 0 | |u https://doi.org/undefined |x Verlag |x Resolving-System |3 Volltext |
| 856 | 4 | 0 | |u http://ar.iiarjournals.org/content/36/10/5205 |x Verlag |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20190710 | ||
| 993 | |a Article | ||
| 994 | |a 2016 | ||
| 998 | |g 128501014 |a Erben, Philipp |m 128501014:Erben, Philipp |d 60000 |d 63100 |e 60000PE128501014 |e 63100PE128501014 |k 0/60000/ |k 1/60000/63100/ |p 9 |y j | ||
| 998 | |g 1062803752 |a Weis, Cleo-Aron Thias |m 1062803752:Weis, Cleo-Aron Thias |d 60000 |d 63400 |e 60000PW1062803752 |e 63400PW1062803752 |k 0/60000/ |k 1/60000/63400/ |p 5 | ||
| 998 | |g 1038074843 |a Steidler, Annette |m 1038074843:Steidler, Annette |d 60000 |d 63100 |e 60000PS1038074843 |e 63100PS1038074843 |k 0/60000/ |k 1/60000/63100/ |p 4 | ||
| 998 | |g 1049742745 |a Kriegmair, Maximilian |m 1049742745:Kriegmair, Maximilian |d 60000 |d 63100 |e 60000PK1049742745 |e 63100PK1049742745 |k 0/60000/ |k 1/60000/63100/ |p 1 |x j | ||
| 999 | |a KXP-PPN1668936372 |e 3492477984 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"person":[{"display":"Kriegmair, Maximilian","role":"aut","given":"Maximilian","family":"Kriegmair"},{"family":"Steidler","role":"aut","given":"Annette","display":"Steidler, Annette"},{"family":"Weis","role":"aut","given":"Cleo-Aron Thias","display":"Weis, Cleo-Aron Thias"},{"given":"Philipp","role":"aut","display":"Erben, Philipp","family":"Erben"}],"name":{"displayForm":["Maximilian Christian Kriegmair, Matthias Balk, Ralph Wirtz, Annette Steidler, Cleo-Aron Weis, Johannes Breyer, Arndt Hartmann, Christian Bolenz and Philipp Erben"]},"physDesc":[{"extent":"9 S."}],"id":{"eki":["1668936372"]},"relHost":[{"part":{"volume":"36","text":"36(2016), 10, Seite 5205-5213","year":"2016","extent":"9","pages":"5205-5213","issue":"10"},"language":["eng"],"title":[{"title_sort":"Anticancer research","title":"Anticancer research","subtitle":"international journal of cancer research and treatment"}],"pubHistory":["Nachgewiesen 24.2004 -"],"name":{"displayForm":["International Institute of Anticancer Research"]},"type":{"media":"Online-Ressource","bibl":"periodical"},"recId":"387478493","origin":[{"publisher":"International Institute of Anticancer Research","dateIssuedDisp":"2004-","dateIssuedKey":"2004","publisherPlace":"Kapandriti, Attiki, Greece"}],"note":["Gesehen am 26.02.13"],"disp":"Expression of the p53 inhibitors MDM2 and MDM4 as outcome predictor in muscle-invasive bladder cancerAnticancer research","id":{"zdb":["2145376-7"],"issn":["1791-7530"],"eki":["387478493"]},"physDesc":[{"extent":"Online-Ressource"}]}],"note":["Gesehen am 10.07.2019"],"type":{"bibl":"article-journal","media":"Online-Ressource"},"origin":[{"dateIssuedKey":"2016","dateIssuedDisp":"October 2016"}],"recId":"1668936372","title":[{"title_sort":"Expression of the p53 inhibitors MDM2 and MDM4 as outcome predictor in muscle-invasive bladder cancer","title":"Expression of the p53 inhibitors MDM2 and MDM4 as outcome predictor in muscle-invasive bladder cancer"}],"language":["eng"]} | ||
| SRT | |a KRIEGMAIRMEXPRESSION2016 | ||