Buchumschlag

Isoliquiritigenin exerts antioxidant activity in Caenorhabditis elegans via insulin-like signaling pathway and SKN-1

Background - Glycyrrhiza uralensis is a well-known medicinal plant. Different therapeutic effects have been reported for its secondary metabolites, including neuroprotective activity. Antioxidant properties have also been documented for some of its compounds and it could be a possible mechanism of n...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Link, Pille (VerfasserIn) , Wink, Michael (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 2019
In: Phytomedicine
Year: 2018, Jahrgang: 55, Pages: 119-124
ISSN:1618-095X
DOI:10.1016/j.phymed.2018.07.004
Online-Zugang:Verlag, Volltext: https://doi.org/10.1016/j.phymed.2018.07.004
Verlag, Volltext: http://www.sciencedirect.com/science/article/pii/S0944711318302563
Volltext
Verfasserangaben:Pille Link, Michael Wink

MARC

LEADER 00000caa a2200000 c 4500
001 166894538X
003 DE-627
005 20240323101235.0
007 cr uuu---uuuuu
008 190710r20192018xx |||||o 00| ||eng c
024 7 |a 10.1016/j.phymed.2018.07.004  |2 doi 
035 |a (DE-627)166894538X 
035 |a (DE-599)KXP166894538X 
035 |a (OCoLC)1341233465 
040 |a DE-627  |b ger  |c DE-627  |e rda 
041 |a eng 
084 |a 32  |2 sdnb 
100 1 |a Link, Pille  |e VerfasserIn  |0 (DE-588)1093603313  |0 (DE-627)853806349  |0 (DE-576)462737675  |4 aut 
245 1 0 |a Isoliquiritigenin exerts antioxidant activity in Caenorhabditis elegans via insulin-like signaling pathway and SKN-1  |c Pille Link, Michael Wink 
264 1 |c 2019 
300 |a 6 
336 |a Text  |b txt  |2 rdacontent 
337 |a Computermedien  |b c  |2 rdamedia 
338 |a Online-Ressource  |b cr  |2 rdacarrier 
500 |a Available online 20 July 2018 
500 |a Gesehen am 10.07.2019 
520 |a Background - Glycyrrhiza uralensis is a well-known medicinal plant. Different therapeutic effects have been reported for its secondary metabolites, including neuroprotective activity. Antioxidant properties have also been documented for some of its compounds and it could be a possible mechanism of neuroprotection. - Purpose - The present study was conducted to investigate the antioxidant effect and underlying pathways of G. uralensis and its main compounds. - Methods - The experiments were conducted with Caenorhabditis elegans, a simple in vivo model, widely used in this context. The methanol extract of G. uralensis and its main compounds isoliquiritigenin, liquiritigenin, glycyrrhizic acid, and glycyrrhetinic acid were tested for their effects on heat shock protein expression under mild oxidative stress and survival rate under lethal oxidative stress. To clarify the underlying pathways, the effect on the transcription factors DAF-16, SKN-1, and HSF-1 was tested. - Results - Isoliquiritigenin was the most potent compound in both assays, leading to a 31% decrease in expression of the stress marker heat shock protein and an 87% increase in survival rate. It significantly activated DAF-16 and SKN-1, but not HSF-1. - Conclusion - The present study identified isoliquiritigenin as the most active antioxidant compound in G. uralensis. It exerts its effect by activating the transcription factors DAF-16/FOXO and SKN-1/Nrf2 which regulate many genes, including those which code for proteins of antioxidative response. This implicates isoliquiritigenin as a possible supplement drug against oxidative stress especially in neurodegenerative diseases. 
534 |c 2018 
650 4 |a Antioxidant activity 
650 4 |a DAF-16/FOXO 
650 4 |a Isoliquiritigenin 
650 4 |a SKN-1/Nrf2 
700 1 |a Wink, Michael  |d 1951-  |e VerfasserIn  |0 (DE-588)124618146  |0 (DE-627)363448519  |0 (DE-576)164659390  |4 aut 
773 0 8 |i Enthalten in  |t Phytomedicine  |d München [u.a.] : Elsevier, 1994  |g 55(2019), Seite 119-124  |h Online-Ressource  |w (DE-627)325793352  |w (DE-600)2040195-4  |w (DE-576)116691972  |x 1618-095X  |7 nnas  |a Isoliquiritigenin exerts antioxidant activity in Caenorhabditis elegans via insulin-like signaling pathway and SKN-1 
773 1 8 |g volume:55  |g year:2019  |g pages:119-124  |g extent:6  |a Isoliquiritigenin exerts antioxidant activity in Caenorhabditis elegans via insulin-like signaling pathway and SKN-1 
856 4 0 |u https://doi.org/10.1016/j.phymed.2018.07.004  |x Verlag  |x Resolving-System  |3 Volltext 
856 4 0 |u http://www.sciencedirect.com/science/article/pii/S0944711318302563  |x Verlag  |3 Volltext 
951 |a AR 
992 |a 20190710 
993 |a Article 
994 |a 2019 
998 |g 124618146  |a Wink, Michael  |m 124618146:Wink, Michael  |d 160000  |d 160100  |e 160000PW124618146  |e 160100PW124618146  |k 0/160000/  |k 1/160000/160100/  |p 2  |y j 
998 |g 1093603313  |a Link, Pille  |m 1093603313:Link, Pille  |d 160000  |d 160100  |e 160000PL1093603313  |e 160100PL1093603313  |k 0/160000/  |k 1/160000/160100/  |p 1  |x j 
999 |a KXP-PPN166894538X  |e 3492499694 
BIB |a Y 
SER |a journal 
JSO |a {"person":[{"role":"aut","given":"Pille","family":"Link","display":"Link, Pille"},{"display":"Wink, Michael","family":"Wink","given":"Michael","role":"aut"}],"relHost":[{"physDesc":[{"extent":"Online-Ressource"}],"recId":"325793352","disp":"Isoliquiritigenin exerts antioxidant activity in Caenorhabditis elegans via insulin-like signaling pathway and SKN-1Phytomedicine","origin":[{"publisher":"Elsevier ; Urban & Fischer","dateIssuedKey":"1994","dateIssuedDisp":"1994-","publisherPlace":"München [u.a.] ; Jena"}],"pubHistory":["1.1994/95 -"],"language":["eng"],"type":{"bibl":"periodical","media":"Online-Ressource"},"note":["Fortsetzung der Druckausgabe","Gesehen am 13.06.2023"],"id":{"eki":["325793352"],"issn":["1618-095X"],"zdb":["2040195-4"]},"part":{"text":"55(2019), Seite 119-124","volume":"55","extent":"6","pages":"119-124","year":"2019"},"title":[{"title":"Phytomedicine","title_sort":"Phytomedicine","subtitle":"international journal of phytotherapy and phytopharmacology"}]}],"origin":[{"dateIssuedKey":"2019","dateIssuedDisp":"2019"}],"note":["Available online 20 July 2018","Gesehen am 10.07.2019"],"language":["eng"],"type":{"media":"Online-Ressource","bibl":"article-journal"},"title":[{"title_sort":"Isoliquiritigenin exerts antioxidant activity in Caenorhabditis elegans via insulin-like signaling pathway and SKN-1","title":"Isoliquiritigenin exerts antioxidant activity in Caenorhabditis elegans via insulin-like signaling pathway and SKN-1"}],"physDesc":[{"extent":"6 S."}],"recId":"166894538X","name":{"displayForm":["Pille Link, Michael Wink"]},"id":{"eki":["166894538X"],"doi":["10.1016/j.phymed.2018.07.004"]}} 
SRT |a LINKPILLEWISOLIQUIRI2019 

Ähnliche Einträge