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Single cell polarity in liquid phase facilitates tumour metastasis

Polarisation of metastasising cancer cells in circulation has not been investigated before. Here the authors identify single cell polarity as a distinct polarisation state of single cells in liquid phase, and show that perturbing single cell polarity affects attachment, adhesion, transmigration and...

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Bibliographic Details
Main Authors: Lorentzen, Anna (Author) , Spaich, Saskia (Author) , Utikal, Jochen (Author) , Sprick, Martin (Author) , Trumpp, Andreas (Author)
Format: Article (Journal)
Language:English
Published: 28 February 2018
In: Nature Communications
Year: 2018, Volume: 9
ISSN:2041-1723
DOI:10.1038/s41467-018-03139-6
Online Access:Verlag, Volltext: https://doi.org/10.1038/s41467-018-03139-6
Verlag, Volltext: https://www.nature.com/articles/s41467-018-03139-6
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Author Notes:Anna Lorentzen, Paul F. Becker, Jan Kosla, Massimo Saini, Kathrin Weidele, Paolo Ronchi, Corinna Klein, Monika J. Wolf, Felix Geist, Bastian Seubert, Marc Ringelhan, Daniela Mihic-Probst, Knud Esser, Marko Roblek, Felix Kuehne, Gaia Bianco, Tracy O’Connor, Quentin Müller, Kathleen Schuck, Sebastian Lange, Daniel Hartmann, Saskia Spaich, Olaf Groß, Jochen Utikal, Sebastian Haferkamp, Martin R. Sprick, Amruta Damle-Vartak, Alexander Hapfelmeier, Norbert Hüser, Ulrike Protzer, Andreas Trumpp, Dieter Saur, Nachiket Vartak, Christoph A. Klein, Bernhard Polzer, Lubor Borsig & Mathias Heikenwalder
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Summary:Polarisation of metastasising cancer cells in circulation has not been investigated before. Here the authors identify single cell polarity as a distinct polarisation state of single cells in liquid phase, and show that perturbing single cell polarity affects attachment, adhesion, transmigration and metastasis in vitro and in vivo.
Item Description:Gesehen am 11.07.2019
Physical Description:Online Resource
ISSN:2041-1723
DOI:10.1038/s41467-018-03139-6

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