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Facial erythema of rosacea - aetiology, different pathophysiologies and treatment options

Rosacea is a common chronic skin condition that displays a broad diversity of clinical manifestations. Although the pathophysiological mechanisms of the four subtypes are not completely elucidated, the key elements often present are augmented immune responses of the innate and adaptive immune system...

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Bibliographic Details
Main Authors: Steinhoff, Martin (Author) , Schmelz, Martin (Author) , Schauber, Jürgen (Author)
Format: Article (Journal)
Language:English
Published: 2016
In: Acta dermato-venereologica
Year: 2015, Volume: 96, Issue: 5, Pages: 579-586
ISSN:1651-2057
DOI:10.2340/00015555-2335
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.2340/00015555-2335
Verlag, kostenfrei, Volltext: http://www.medicaljournals.se/acta/content/?doi=10.2340/00015555-2335
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Author Notes:Martin Steinhoff, Martin Schmelz and Jürgen Schauber

MARC

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520 |a Rosacea is a common chronic skin condition that displays a broad diversity of clinical manifestations. Although the pathophysiological mechanisms of the four subtypes are not completely elucidated, the key elements often present are augmented immune responses of the innate and adaptive immune system, and neurovascular dysregulation. The most common primary feature of all cutaneous subtypes of rosacea is transient or persistent facial erythema. Perilesional erythema of papules or pustules is based on the sustained vasodilation and plasma extravasation induced by the inflammatory infiltrates. In contrast, transient erythema has rapid kinetics induced by trigger factors independent of papules or pustules. Amongst the current treatments for facial erythema of rosacea, only the selective α2-adrenergic receptor agonist brimonidine 0.33% topical gel (Mirvaso®) is approved. This review aims to discuss the potential causes, different pathophysiologies and current treatment options to address the unmet medical needs of patients with facial erythema of rosacea. 
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