Buchumschlag

Cell type-dependent integrin distribution in adhesion and migration responses on protein-coated microgrooved substrates

Although integrins are responsible for the interaction of cells with their environment, e.g., the extracellular matrix or artificial substrates, there is still a lack of knowledge about their role in cell adhesion and migration on protein-coated substrates with microtopography. Understanding such in...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Sales Ramos, Adrià (VerfasserIn) , Spatz, Joachim P. (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 22 January 2019
In: ACS omega
Year: 2019, Jahrgang: 4, Heft: 1, Pages: 1791-1800
ISSN:2470-1343
DOI:10.1021/acsomega.8b03608
Online-Zugang:Verlag, Volltext: https://doi.org/10.1021/acsomega.8b03608
Volltext
Verfasserangaben:Adria Sales, Karen Ende, Jennifer Diemer, Adriana R. Kyvik, Jaume Veciana, Imma Ratera, Ralf Kemkemer, Joachim P. Spatz, and Judith Guasch

MARC

LEADER 00000caa a2200000 c 4500
001 1669031004
003 DE-627
005 20230428192200.0
007 cr uuu---uuuuu
008 190711s2019 xx |||||o 00| ||eng c
024 7 |a 10.1021/acsomega.8b03608  |2 doi 
035 |a (DE-627)1669031004 
035 |a (DE-599)KXP1669031004 
035 |a (OCoLC)1341233639 
040 |a DE-627  |b ger  |c DE-627  |e rda 
041 |a eng 
084 |a 29  |2 sdnb 
100 1 |a Sales Ramos, Adrià  |e VerfasserIn  |0 (DE-588)1103834800  |0 (DE-627)861560639  |0 (DE-576)470782684  |4 aut 
245 1 0 |a Cell type-dependent integrin distribution in adhesion and migration responses on protein-coated microgrooved substrates  |c Adria Sales, Karen Ende, Jennifer Diemer, Adriana R. Kyvik, Jaume Veciana, Imma Ratera, Ralf Kemkemer, Joachim P. Spatz, and Judith Guasch 
264 1 |c 22 January 2019 
300 |a 10 
336 |a Text  |b txt  |2 rdacontent 
337 |a Computermedien  |b c  |2 rdamedia 
338 |a Online-Ressource  |b cr  |2 rdacarrier 
500 |a Gesehen am 11.07.2019 
520 |a Although integrins are responsible for the interaction of cells with their environment, e.g., the extracellular matrix or artificial substrates, there is still a lack of knowledge about their role in cell adhesion and migration on protein-coated substrates with microtopography. Understanding such interactions could lead to new applications in e.g., medical implants as well as shed light on processes such as embryonic development, angiogenesis, wound healing, and tumor progression. In this work, the influence of surface topography and chemistry on αvβ3 and α5β1 integrin-mediated cell adhesion and migration of healthy and malignant human cell types (human coronary artery endothelial cells, human osteosarcoma cells, and human skin fibroblasts cells) was studied, using microgrooved and flat substrates covered by two different extracellular proteins, fibronectin and vitronectin. Although some general behaviors can be observed, cell migration (speed, directionality, and persistence time) and morphological adaptation (cell area, aspect ratio, and circularity) of cells on protein-coated microgrooved substrates are mainly dependent on the cell type and its specific integrin expression. 
700 1 |a Spatz, Joachim P.  |d 1969-  |e VerfasserIn  |0 (DE-588)122582675  |0 (DE-627)08203124X  |0 (DE-576)173014771  |4 aut 
773 0 8 |i Enthalten in  |t ACS omega  |d Washington, DC : ACS Publications, 2016  |g 4(2019), 1, Seite 1791-1800  |h Online-Ressource  |w (DE-627)863132308  |w (DE-600)2861993-6  |w (DE-576)474097676  |x 2470-1343  |7 nnas  |a Cell type-dependent integrin distribution in adhesion and migration responses on protein-coated microgrooved substrates 
773 1 8 |g volume:4  |g year:2019  |g number:1  |g pages:1791-1800  |g extent:10  |a Cell type-dependent integrin distribution in adhesion and migration responses on protein-coated microgrooved substrates 
856 4 0 |u https://doi.org/10.1021/acsomega.8b03608  |x Verlag  |x Resolving-System  |3 Volltext 
951 |a AR 
992 |a 20190711 
993 |a Article 
994 |a 2019 
998 |g 122582675  |a Spatz, Joachim P.  |m 122582675:Spatz, Joachim P.  |d 120000  |d 120300  |e 120000PS122582675  |e 120300PS122582675  |k 0/120000/  |k 1/120000/120300/  |p 8 
999 |a KXP-PPN1669031004  |e 3492710417 
BIB |a Y 
SER |a journal 
JSO |a {"note":["Gesehen am 11.07.2019"],"type":{"media":"Online-Ressource","bibl":"article-journal"},"recId":"1669031004","language":["eng"],"person":[{"display":"Sales Ramos, Adrià","roleDisplay":"VerfasserIn","role":"aut","family":"Sales Ramos","given":"Adrià"},{"given":"Joachim P.","family":"Spatz","role":"aut","display":"Spatz, Joachim P.","roleDisplay":"VerfasserIn"}],"title":[{"title_sort":"Cell type-dependent integrin distribution in adhesion and migration responses on protein-coated microgrooved substrates","title":"Cell type-dependent integrin distribution in adhesion and migration responses on protein-coated microgrooved substrates"}],"physDesc":[{"extent":"10 S."}],"relHost":[{"pubHistory":["Volume 1, issue 1 (July 2016)-"],"part":{"extent":"10","text":"4(2019), 1, Seite 1791-1800","volume":"4","pages":"1791-1800","issue":"1","year":"2019"},"disp":"Cell type-dependent integrin distribution in adhesion and migration responses on protein-coated microgrooved substratesACS omega","type":{"bibl":"periodical","media":"Online-Ressource"},"note":["Gesehen am 25.06.2025"],"language":["eng"],"corporate":[{"role":"isb","display":"American Chemical Society","roleDisplay":"Herausgebendes Organ"}],"recId":"863132308","title":[{"title":"ACS omega","title_sort":"ACS omega"}],"physDesc":[{"extent":"Online-Ressource"}],"origin":[{"publisher":"ACS Publications","dateIssuedDisp":"[2016]-","publisherPlace":"Washington, DC"}],"id":{"issn":["2470-1343"],"eki":["863132308"],"zdb":["2861993-6"]},"name":{"displayForm":["American Chemical Society"]}}],"name":{"displayForm":["Adria Sales, Karen Ende, Jennifer Diemer, Adriana R. Kyvik, Jaume Veciana, Imma Ratera, Ralf Kemkemer, Joachim P. Spatz, and Judith Guasch"]},"origin":[{"dateIssuedKey":"2019","dateIssuedDisp":"22 January 2019"}],"id":{"eki":["1669031004"],"doi":["10.1021/acsomega.8b03608"]}} 
SRT |a SALESRAMOSCELLTYPEDE2220 

Ähnliche Einträge