Value of lipopolysaccharide binding protein, interleukin-6 and C-reactive protein as biomarkers of severity in acute diverticulitis: a prospective study
BACKGROUND: New biomarkers have the capability to predict severity and outcome of infectious diseases. Lipopolysaccharide binding protein (LBP) and Interleukin 6 (IL-6) were determined as new markers in patients with acute diverticulitis and were compared with standard markers such as C-reactive pro...
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| Hauptverfasser: | , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
January 2012
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| In: |
Clinical laboratory
Year: 2012, Jahrgang: 58, Heft: 1/2, Pages: 145-151 |
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| Verfasserangaben: | Christoph Elsing, Susanne Ernst, Wolfgang Stremmel |
MARC
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| 245 | 1 | 0 | |a Value of lipopolysaccharide binding protein, interleukin-6 and C-reactive protein as biomarkers of severity in acute diverticulitis |b a prospective study |c Christoph Elsing, Susanne Ernst, Wolfgang Stremmel |
| 264 | 1 | |c January 2012 | |
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| 520 | |a BACKGROUND: New biomarkers have the capability to predict severity and outcome of infectious diseases. Lipopolysaccharide binding protein (LBP) and Interleukin 6 (IL-6) were determined as new markers in patients with acute diverticulitis and were compared with standard markers such as C-reactive protein (CRP) and white blood cell count (WBC). - METHODS: CRP, IL-6, WBC and LBP were measured in 38 patients at hospital admission and every second day and after colonoscopy. Multi-slice CT scans, ultrasound and early colonoscopy were performed to confirm diagnosis and to detect complications (perforations, stenosis). - RESULTS: CRP, IL-6 and LBP levels one correlated highly with each other and were equally influenced by antibiotic therapy. WBC changes were unremarkable. Severity of the disease (sealed- or non-perforation) was not reflected by the biomarkers. In non-perforated patients, colonoscopy was performed on day 6 (median) after admission with a success rate of 93%. Sealed-perforated patients were examined on median day 11 with a success rate of 60% (p > 0.001). Failure in all cases was due to sigmoidal stenosis requiring surgery. In a receiver-operating characteristic curve analysis (ROC), LBP on day one performed best in predicting colonic steno-sis with an area under the curve of 0.88 (95% CI 0.73 - 0.03 p < 0.02). - CONCLUSIONS: CRP, IL-6, and LBP can be used to monitor diverticulitis. Initial LBP values in patients with acute diverticulitis may also be usefully in detecting candidates for surgical intervention. | ||
| 650 | 4 | |a Acute Disease | |
| 650 | 4 | |a Acute-Phase Proteins | |
| 650 | 4 | |a Anti-Bacterial Agents | |
| 650 | 4 | |a C-Reactive Protein | |
| 650 | 4 | |a Carrier Proteins | |
| 650 | 4 | |a Colonoscopy | |
| 650 | 4 | |a Diverticulitis, Colonic | |
| 650 | 4 | |a Female | |
| 650 | 4 | |a Humans | |
| 650 | 4 | |a Interleukin-6 | |
| 650 | 4 | |a Male | |
| 650 | 4 | |a Membrane Glycoproteins | |
| 650 | 4 | |a Middle Aged | |
| 650 | 4 | |a Monitoring, Physiologic | |
| 650 | 4 | |a Prognosis | |
| 650 | 4 | |a Prospective Studies | |
| 650 | 4 | |a ROC Curve | |
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| 700 | 1 | |a Stremmel, Wolfgang |d 1952- |e VerfasserIn |0 (DE-588)142773638 |0 (DE-627)640118747 |0 (DE-576)33331560X |4 aut | |
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