Impact of c-MYC expression on proliferation, differentiation, and risk of neoplastic transformation of human mesenchymal stromal cells
Mesenchymal stromal cells isolated from bone marrow (MSC) represent an attractive source of adult stem cells for regenerative medicine. However, thorough research is required into their clinical application safety issues concerning a risk of potential neoplastic degeneration in a process of MSC prop...
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| Main Authors: | , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
5 March 2019
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| In: |
Stem cell research & therapy
Year: 2019, Volume: 10, Pages: 1-18 |
| ISSN: | 1757-6512 |
| DOI: | 10.1186/s13287-019-1187-z |
| Online Access: | Verlag, Volltext: https://doi.org/10.1186/s13287-019-1187-z
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| Author Notes: | Svitlana Melnik, Nadine Werth, Stephane Boeuf, Eva-Maria Hahn, Tobias Gotterbarm, Martina Anton and Wiltrud Richter |
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| 520 | |a Mesenchymal stromal cells isolated from bone marrow (MSC) represent an attractive source of adult stem cells for regenerative medicine. However, thorough research is required into their clinical application safety issues concerning a risk of potential neoplastic degeneration in a process of MSC propagation in cell culture for therapeutic applications. Expansion protocols could preselect MSC with elevated levels of growth-promoting transcription factors with oncogenic potential, such as c-MYC. We addressed the question whether c-MYC expression affects the growth and differentiation potential of human MSC upon extensive passaging in cell culture and assessed a risk of tumorigenic transformation caused by MSC overexpressing c-MYC in vivo. | ||
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