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Synthesis and structure-activity relationships of small-molecular di-basic esters, amides and carbamates as flaviviral protease inhibitors

Inhibitors of the flaviviral serine proteases, which are crucial for the replication of dengue and West-Nile virus, have attracted much attention over the last years. A dibasic 4-guanidinobenzoate was previously reported as inhibitor of the dengue protease with potency in the low-micromolar range. I...

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Bibliographic Details
Main Authors: Sundermann, Tom R. (Author) , Dražić, Tonko (Author) , Klein, Christian D. (Author)
Format: Article (Journal)
Language:English
Published: 8 May 2019
In: European journal of medicinal chemistry
Year: 2019, Volume: 176, Pages: 187-194
ISSN:1768-3254
DOI:10.1016/j.ejmech.2019.05.025
Online Access:Verlag, Volltext: http://dx.doi.org/10.1016/j.ejmech.2019.05.025
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Author Notes:Tom R. Sundermann, Clarissa V. Benzin, Tonko Dražić, Christian D. Klein

MARC

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