Semi-automatic volumetric measurement of treatment response in hepatocellular carcinoma after trans-arterial chemoembolization
Aim: To perform a quantitative, volumetric analysis of therapeutic effects of trans-arterial chemoembolization (TACE) in hepatocellular carcinoma (HCC) patients. Patients and Methods: Entire tumor volume and a subset of hypervascular tumor portions were analyzed pre- and post-TACE in magnetic resona...
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| Main Authors: | , , , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
August 2016
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| In: |
Anticancer research
Year: 2016, Volume: 36, Issue: 8, Pages: 4353-4358 |
| ISSN: | 1791-7530 |
| DOI: | undefined |
| Online Access: | Verlag, Volltext: https://doi.org/undefined Verlag, Volltext: http://ar.iiarjournals.org/content/36/8/4353 
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| Author Notes: | Johannes Budjan, Elke A. Sauter, John N. Morelli, Marco Nolden, Andreas Fetzer, Lothar Pilz, Miriam Reichert, Theresa Brandt, Jan Hansmann, Stefan Haneder, Nils Rathmann, Steffen J. Diehl, Hans-Peter Meinzer, Stefan O. Schoenberg and Ulrike I. Attenberger |
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| 245 | 1 | 0 | |a Semi-automatic volumetric measurement of treatment response in hepatocellular carcinoma after trans-arterial chemoembolization |c Johannes Budjan, Elke A. Sauter, John N. Morelli, Marco Nolden, Andreas Fetzer, Lothar Pilz, Miriam Reichert, Theresa Brandt, Jan Hansmann, Stefan Haneder, Nils Rathmann, Steffen J. Diehl, Hans-Peter Meinzer, Stefan O. Schoenberg and Ulrike I. Attenberger |
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| 520 | |a Aim: To perform a quantitative, volumetric analysis of therapeutic effects of trans-arterial chemoembolization (TACE) in hepatocellular carcinoma (HCC) patients. Patients and Methods: Entire tumor volume and a subset of hypervascular tumor portions were analyzed pre- and post-TACE in magnetic resonance imaging datasets of 22 HCC patients using a semi-automated segmentation and evaluation tool from the Medical Imaging Interaction Toolkit. Results were compared to mRECIST measurements and inter-reader variability was assessed. Results: Mean total tumor volume increased statistical significantly after TACE (84.6 ml pre- vs. 97.1 ml post-TACE, p=0.03) while hypervascular tumor volume decreased from 9.1 ml pre- to 3.7 ml post-TACE (p=0.0001). Likewise, mRECIST diameters decreased significantly after therapy (44.2 vs. 15.4 mm). In the inter-reader assessment, overlap errors were 12.3-17.7% for entire and 36.3-64.2% for the enhancing tumor volume. Conclusion: Quantification of therapeutic changes after TACE therapy is feasible using a semi-automated segmentation and evaluation tool. Following TACE, hypervascular tumor volume decreases significantly. | ||
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