Quality of life of short-statured children born small for gestational age or idiopathic growth hormone deficiency within 1 year of growth hormone treatment
Aside from clinical endpoints like height gain, health-related quality of life has also become an important outcome indicator in the medical field. However, the data on short stature and health-related quality of life is inconsistent. Therefore, we examined changes in health-related quality of life...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , , , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
29 April 2019
|
| In: |
Frontiers in Pediatrics
Year: 2019, Jahrgang: 7 |
| ISSN: | 2296-2360 |
| DOI: | 10.3389/fped.2019.00164 |
| Online-Zugang: | Verlag, Volltext: https://doi.org/10.3389/fped.2019.00164 Verlag, Volltext: https://www.frontiersin.org/articles/10.3389/fped.2019.00164/full 
|
| Verfasserangaben: | Julia Quitmann, Janika Bloemeke, Neuza Silva, Monika Bullinger, Stefanie Witt, Ilker Akkurt, Desiree Dunstheimer, Christian Vogel, Volker Böttcher, Ursula Kuhnle Krahl, Markus Bettendorf, Eckhard Schönau, Susanne Fricke-Otto, Alexandra Keller, Klaus Mohnike, Helmuth-Günther Dörr |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1669310043 | ||
| 003 | DE-627 | ||
| 005 | 20241217204817.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 190717s2019 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.3389/fped.2019.00164 |2 doi | |
| 035 | |a (DE-627)1669310043 | ||
| 035 | |a (DE-599)KXP1669310043 | ||
| 035 | |a (OCoLC)1341233842 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Quitmann, Julia |e VerfasserIn |0 (DE-588)1011779455 |0 (DE-627)659319454 |0 (DE-576)343658054 |4 aut | |
| 245 | 1 | 0 | |a Quality of life of short-statured children born small for gestational age or idiopathic growth hormone deficiency within 1 year of growth hormone treatment |c Julia Quitmann, Janika Bloemeke, Neuza Silva, Monika Bullinger, Stefanie Witt, Ilker Akkurt, Desiree Dunstheimer, Christian Vogel, Volker Böttcher, Ursula Kuhnle Krahl, Markus Bettendorf, Eckhard Schönau, Susanne Fricke-Otto, Alexandra Keller, Klaus Mohnike, Helmuth-Günther Dörr |
| 264 | 1 | |c 29 April 2019 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 17.07.2019 | ||
| 520 | |a Aside from clinical endpoints like height gain, health-related quality of life has also become an important outcome indicator in the medical field. However, the data on short stature and health-related quality of life is inconsistent. Therefore, we examined changes in health-related quality of life in German children with idiopathic growth hormone deficiency or children born small for gestational age before and after 12 months of human growth hormone treatment. Children with idiopathic short stature without treatment served as a comparison group. At baseline, health-related quality of life data of 154 patients with idiopathic growth hormone deficiency (n = 65), born small for gestational age (n = 58) and idiopathic short stature (n = 31) and one parent each was collected. Of these, 130 completed health-related quality of life assessments after 1-year of human growth hormone treatment. Outcome measures included the Quality of Life in Short Stature Youth questionnaire, as well as clinical and sociodemographic data. Our results showed that the physical, social, and emotional health-related quality of life of children treated with human growth hormone significantly increased, while untreated patients with idiopathic short stature reported a decrease in these domains. Along with this, a statistically significant increase in height in the treated group can be observed, while the slight increase in the untreated group was not significant. In conclusion, the results showed that human growth hormone treatment may have a positive effect not only on height but also in improving patient-reported health-related quality of life of children with idiopathic growth hormone deficiency and children born small for gestational age. | ||
| 650 | 4 | |a growth hormone treatment | |
| 650 | 4 | |a health-related quality of life | |
| 650 | 4 | |a IGHD | |
| 650 | 4 | |a ISS | |
| 650 | 4 | |a QoLISSY | |
| 650 | 4 | |a short stature | |
| 700 | 1 | |a Bloemeke, Janika |e VerfasserIn |4 aut | |
| 700 | 1 | |a Silva, Neuza |e VerfasserIn |4 aut | |
| 700 | 1 | |a Bullinger, Monika |d 1954- |e VerfasserIn |0 (DE-588)122497325 |0 (DE-627)081979517 |0 (DE-576)160479916 |4 aut | |
| 700 | 1 | |8 1\p |a Witt, Stefanie |e VerfasserIn |0 (DE-588)1261110897 |0 (DE-627)1886439028 |4 aut | |
| 700 | 1 | |a Akkurt, Ilker |e VerfasserIn |4 aut | |
| 700 | 1 | |a Dunstheimer, Désirée Patricia Alexandra |d 1973- |e VerfasserIn |0 (DE-588)123337038 |0 (DE-627)70626147X |0 (DE-576)293662827 |4 aut | |
| 700 | 1 | |a Vogel, Christian |e VerfasserIn |4 aut | |
| 700 | 1 | |a Böttcher, Volker |e VerfasserIn |4 aut | |
| 700 | 1 | |a Kuhnle Krahl, Ursula |e VerfasserIn |4 aut | |
| 700 | 1 | |a Bettendorf, Markus |e VerfasserIn |0 (DE-588)111028876 |0 (DE-627)589912151 |0 (DE-576)30212246X |4 aut | |
| 700 | 1 | |a Schönau, Eckhard |d 1958- |e VerfasserIn |0 (DE-588)1140738046 |0 (DE-627)898652553 |0 (DE-576)493999698 |4 aut | |
| 700 | 1 | |a Fricke-Otto, Susanne |e VerfasserIn |0 (DE-588)1157332447 |0 (DE-627)102118585X |0 (DE-576)502863072 |4 aut | |
| 700 | 1 | |a Keller, Alexdandra |e VerfasserIn |4 aut | |
| 700 | 1 | |a Mohnike, Klaus |e VerfasserIn |0 (DE-588)1048451526 |0 (DE-627)780429435 |0 (DE-576)40227184X |4 aut | |
| 700 | 1 | |a Dörr, Helmuth-Günther |d 1952- |e VerfasserIn |0 (DE-588)112808905 |0 (DE-627)504632892 |0 (DE-576)166815039 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Frontiers in Pediatrics |d Lausanne : Frontiers Media, 2013 |g 7(2019) Artikel-Nummer 164, 11 Seiten |h Online-Ressource |w (DE-627)742738744 |w (DE-600)2711999-3 |w (DE-576)381569756 |x 2296-2360 |7 nnas |a Quality of life of short-statured children born small for gestational age or idiopathic growth hormone deficiency within 1 year of growth hormone treatment |
| 773 | 1 | 8 | |g volume:7 |g year:2019 |a Quality of life of short-statured children born small for gestational age or idiopathic growth hormone deficiency within 1 year of growth hormone treatment |
| 856 | 4 | 0 | |u https://doi.org/10.3389/fped.2019.00164 |x Verlag |x Resolving-System |3 Volltext |
| 856 | 4 | 0 | |u https://www.frontiersin.org/articles/10.3389/fped.2019.00164/full |x Verlag |3 Volltext |
| 883 | |8 1\p |a cgwrk |d 20241001 |q DE-101 |u https://d-nb.info/provenance/plan#cgwrk | ||
| 951 | |a AR | ||
| 992 | |a 20190717 | ||
| 993 | |a Article | ||
| 994 | |a 2019 | ||
| 998 | |g 111028876 |a Bettendorf, Markus |m 111028876:Bettendorf, Markus |d 910000 |d 910500 |d 50000 |e 910000PB111028876 |e 910500PB111028876 |e 50000PB111028876 |k 0/910000/ |k 1/910000/910500/ |k 0/50000/ |p 11 | ||
| 999 | |a KXP-PPN1669310043 |e 3493864582 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"id":{"eki":["1669310043"],"doi":["10.3389/fped.2019.00164"]},"title":[{"title_sort":"Quality of life of short-statured children born small for gestational age or idiopathic growth hormone deficiency within 1 year of growth hormone treatment","title":"Quality of life of short-statured children born small for gestational age or idiopathic growth hormone deficiency within 1 year of growth hormone treatment"}],"type":{"bibl":"article-journal","media":"Online-Ressource"},"origin":[{"dateIssuedDisp":" 29 April 2019","dateIssuedKey":"2019"}],"relHost":[{"recId":"742738744","origin":[{"dateIssuedDisp":"2013-","publisher":"Frontiers Media","publisherPlace":"Lausanne","dateIssuedKey":"2013"}],"id":{"issn":["2296-2360"],"eki":["742738744"],"zdb":["2711999-3"]},"physDesc":[{"extent":"Online-Ressource"}],"title":[{"title_sort":"Frontiers in Pediatrics","title":"Frontiers in Pediatrics"}],"pubHistory":["2013 -"],"note":["Gesehen am 04.06.20"],"part":{"text":"7(2019) Artikel-Nummer 164, 11 Seiten","volume":"7","year":"2019"},"language":["eng"],"titleAlt":[{"title":"FPED"}],"disp":"Quality of life of short-statured children born small for gestational age or idiopathic growth hormone deficiency within 1 year of growth hormone treatmentFrontiers in Pediatrics","type":{"media":"Online-Ressource","bibl":"periodical"}}],"language":["eng"],"name":{"displayForm":["Julia Quitmann, Janika Bloemeke, Neuza Silva, Monika Bullinger, Stefanie Witt, Ilker Akkurt, Desiree Dunstheimer, Christian Vogel, Volker Böttcher, Ursula Kuhnle Krahl, Markus Bettendorf, Eckhard Schönau, Susanne Fricke-Otto, Alexandra Keller, Klaus Mohnike, Helmuth-Günther Dörr"]},"note":["Gesehen am 17.07.2019"],"recId":"1669310043","person":[{"display":"Quitmann, Julia","given":"Julia","role":"aut","family":"Quitmann"},{"display":"Bloemeke, Janika","given":"Janika","role":"aut","family":"Bloemeke"},{"family":"Silva","role":"aut","given":"Neuza","display":"Silva, Neuza"},{"role":"aut","family":"Bullinger","given":"Monika","display":"Bullinger, Monika"},{"display":"Witt, Stefanie","given":"Stefanie","role":"aut","family":"Witt"},{"role":"aut","family":"Akkurt","given":"Ilker","display":"Akkurt, Ilker"},{"family":"Dunstheimer","role":"aut","display":"Dunstheimer, Désirée Patricia Alexandra","given":"Désirée Patricia Alexandra"},{"family":"Vogel","role":"aut","given":"Christian","display":"Vogel, Christian"},{"family":"Böttcher","role":"aut","given":"Volker","display":"Böttcher, Volker"},{"display":"Kuhnle Krahl, Ursula","given":"Ursula","family":"Kuhnle Krahl","role":"aut"},{"given":"Markus","display":"Bettendorf, Markus","family":"Bettendorf","role":"aut"},{"role":"aut","family":"Schönau","given":"Eckhard","display":"Schönau, Eckhard"},{"display":"Fricke-Otto, Susanne","given":"Susanne","family":"Fricke-Otto","role":"aut"},{"role":"aut","family":"Keller","given":"Alexdandra","display":"Keller, Alexdandra"},{"family":"Mohnike","role":"aut","given":"Klaus","display":"Mohnike, Klaus"},{"role":"aut","family":"Dörr","given":"Helmuth-Günther","display":"Dörr, Helmuth-Günther"}]} | ||
| SRT | |a QUITMANNJUQUALITYOFL2920 | ||