Long intergenic noncoding RNA 299 methylation in peripheral blood is a biomarker for triple-negative breast cancer
Aim: To identify DNA methylation biomarkers in peripheral blood samples from triple-negative breast cancer (TNBC) patients. Materials & methods: We conducted an epigenome-wide association study (EWAS): the most promising markers were identified in 233 TNBC case–control pairs (discovery set) and...
Gespeichert in:
| Hauptverfasser: | , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
2019
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| In: |
Epigenomics
Year: 2019, Jahrgang: 11, Heft: 1, Pages: 81-93 |
| ISSN: | 1750-192X |
| DOI: | 10.2217/epi-2018-0121 |
| Online-Zugang: | Verlag, Volltext: https://doi.org/10.2217/epi-2018-0121 Verlag, Volltext: https://www.futuremedicine.com/doi/10.2217/epi-2018-0121 
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| Verfasserangaben: | Justo L Bermejo, Guanmengqian Huang, Mehdi Manoochehri, Karen G Mesa, Matthias Schick, Rosa G Silos, Yon-Dschun Ko, Thomas Brüning, Hiltrud Brauch, Wing-Yee Lo, Jörg D Hoheisel & Ute Hamann |
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| 245 | 1 | 0 | |a Long intergenic noncoding RNA 299 methylation in peripheral blood is a biomarker for triple-negative breast cancer |c Justo L Bermejo, Guanmengqian Huang, Mehdi Manoochehri, Karen G Mesa, Matthias Schick, Rosa G Silos, Yon-Dschun Ko, Thomas Brüning, Hiltrud Brauch, Wing-Yee Lo, Jörg D Hoheisel & Ute Hamann |
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| 520 | |a Aim: To identify DNA methylation biomarkers in peripheral blood samples from triple-negative breast cancer (TNBC) patients. Materials & methods: We conducted an epigenome-wide association study (EWAS): the most promising markers were identified in 233 TNBC case–control pairs (discovery set) and subsequently validated in an independent validation set (57 TNBC patients and 124 controls). Results: cg06588802 (LINC00299/ID2) showed a higher methylation in TNBC patients compared with controls (discovery set: 3% increase, p-value = 0.0009; validation set: 2% increase, p-value = 0.01). Consistent results at four neighboring methylation probes and the strong negative correlation (rho = -0.93) with LINC00299 expression add plausibility to this result. Conclusion: Hypermethylation of LINC00299 in peripheral blood may constitute a useful circulating biomarker for TNBC. | ||
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