Thresholding of cryo-EM density maps by false discovery rate control
The interpretation of cryo-EM density by atomic models remains a daunting task owing to the identification of appropriate threshold levels at low signal-to-noise ratios in high-resolution shells and weak structural features. It is shown that transforming cryo-EM densities to confidence maps followed...
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| Hauptverfasser: | , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
2019
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| In: |
IUCrJ
Year: 2018, Jahrgang: 6, Heft: 1, Pages: 18-33 |
| ISSN: | 2052-2525 |
| DOI: | 10.1107/S2052252518014434 |
| Online-Zugang: | Verlag, Volltext: https://doi.org/10.1107/S2052252518014434 Verlag, Volltext: https://journals.iucr.org/m/issues/2019/01/00/pw5002/ 
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| Verfasserangaben: | Maximilian Beckers, Arjen J. Jakobi and Carsten Sachse |
| Zusammenfassung: | The interpretation of cryo-EM density by atomic models remains a daunting task owing to the identification of appropriate threshold levels at low signal-to-noise ratios in high-resolution shells and weak structural features. It is shown that transforming cryo-EM densities to confidence maps followed by false discovery rate-based thresholding provides a robust way to interpret cryo-EM structures. |
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| Beschreibung: | Accepted 12 October 2018 Gesehen am 19.07.2019 |
| Beschreibung: | Online Resource |
| ISSN: | 2052-2525 |
| DOI: | 10.1107/S2052252518014434 |