Molecular and pharmacological modulators of the tumor immune contexture revealed by deconvolution of RNA-seq data
We introduce quanTIseq, a method to quantify the fractions of ten immune cell types from bulk RNA-sequencing data. quanTIseq was extensively validated in blood and tumor samples using simulated, flow cytometry, and immunohistochemistry data.
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| Hauptverfasser: | , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
24 May 2019
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| In: |
Genome medicine
Year: 2019, Jahrgang: 11 |
| ISSN: | 1756-994X |
| DOI: | 10.1186/s13073-019-0638-6 |
| Online-Zugang: | Verlag, Volltext: https://doi.org/10.1186/s13073-019-0638-6
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| Verfasserangaben: | Francesca Finotello, Clemens Mayer, Christina Plattner, Gerhard Laschober, Dietmar Rieder, Hubert Hackl, Anne Krogsdam, Zuzana Loncova, Wilfried Posch, Doris Wilflingseder, Sieghart Sopper, Marieke Ijsselsteijn, Thomas P. Brouwer, Douglas Johnson, Yaomin Xu, Yu Wang, Melinda E. Sanders, Monica V. Estrada, Paula Ericsson-Gonzalez, Pornpimol Charoentong, Justin Balko, Noel Filipe da Cunha Carvahlo de Miranda, Zlatko Trajanoski |
| Zusammenfassung: | We introduce quanTIseq, a method to quantify the fractions of ten immune cell types from bulk RNA-sequencing data. quanTIseq was extensively validated in blood and tumor samples using simulated, flow cytometry, and immunohistochemistry data. |
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| Beschreibung: | Gesehen am 22.07.2019 |
| Beschreibung: | Online Resource |
| ISSN: | 1756-994X |
| DOI: | 10.1186/s13073-019-0638-6 |