Buchumschlag

Nucleoporin Nup155 is part of the p53 network in liver cancer

The nuclear pore complex (NPC) is known to regulate p53 signaling and this has mainly been linked to peripheral NPC subunits. Here the authors show that Nup155 from the NPC inner ring regulates the p53 pathway by controlling p21 translation while also being a target of p53-mediated repression.

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Bibliographische Detailangaben
Hauptverfasser: Holzer, Kerstin (VerfasserIn) , Drucker, Elisabeth (VerfasserIn) , Baßler, Jochen (VerfasserIn) , Rössler, Stephanie (VerfasserIn) , Breuhahn, Kai (VerfasserIn) , Hurt, Ed (VerfasserIn) , Schirmacher, Peter (VerfasserIn) , Singer, Stephan (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 14 May 2019
In: Nature Communications
Year: 2019, Jahrgang: 10
ISSN:2041-1723
DOI:10.1038/s41467-019-10133-z
Online-Zugang:Verlag, Volltext: https://doi.org/10.1038/s41467-019-10133-z
Verlag, Volltext: https://www.nature.com/articles/s41467-019-10133-z
Volltext
Verfasserangaben:Kerstin Holzer, Alessandro Ori, Amy Cooke, Daniel Dauch, Elisabeth Drucker, Philip Riemenschneider, Amparo Andres-Pons, Amanda L. DiGuilio, Marie-Therese Mackmull, Jochen Baßler, Stephanie Roessler, Kai Breuhahn, Lars Zender, Joseph S. Glavy, Frank Dombrowski, Ed Hurt, Peter Schirmacher, Martin Beck & Stephan Singer
Beschreibung
Zusammenfassung:The nuclear pore complex (NPC) is known to regulate p53 signaling and this has mainly been linked to peripheral NPC subunits. Here the authors show that Nup155 from the NPC inner ring regulates the p53 pathway by controlling p21 translation while also being a target of p53-mediated repression.
Beschreibung:Gesehen am 22.07.2019
Beschreibung:Online Resource
ISSN:2041-1723
DOI:10.1038/s41467-019-10133-z

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