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Stem cell topography splits growth and homeostatic functions in the fish gill

While lower vertebrates contain adult stem cells (aSCs) that maintain homeostasis and drive un-exhaustive organismal growth, mammalian aSCs display mainly the homeostatic function. Here, we use lineage analysis in the medaka fish gill to address aSCs and report separate stem cell populations for hom...

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Hauptverfasser: Stolper, Julian (VerfasserIn) , Ambrosio, Elizabeth (VerfasserIn) , Danciu, Diana-Patricia (VerfasserIn) , Marciniak-Czochra, Anna (VerfasserIn) , Centanin, Lázaro (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: May 24, 2019
In: eLife
Year: 2019, Jahrgang: 8
ISSN:2050-084X
DOI:10.7554/eLife.43747
Online-Zugang:Verlag, Volltext: https://doi.org/10.7554/eLife.43747
Volltext
Verfasserangaben:Julian Stolper, Elizabeth Mayela Ambrosio, Diana-Patricia Danciu, Lorena Buono, David A Elliott, Kiyoshi Naruse, Juan R Martínez-Morales, Anna Marciniak-Czochra, Lazaro Centanin
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Zusammenfassung:While lower vertebrates contain adult stem cells (aSCs) that maintain homeostasis and drive un-exhaustive organismal growth, mammalian aSCs display mainly the homeostatic function. Here, we use lineage analysis in the medaka fish gill to address aSCs and report separate stem cell populations for homeostasis and growth. These aSCs are fate-restricted during the entire post-embryonic life and even during re-generation paradigms. We use chimeric animals to demonstrate that p53 mediates growth coordination among fate-restricted aSCs, suggesting a hierarchical organisation among lineages in composite organs like the fish gill. Homeostatic and growth aSCs are clonal but differ in their topology; modifications in tissue architecture can convert the homeostatic zone into a growth zone, indicating a leading role for the physical niche defining stem cell output. We hypothesise that physical niches are main players to restrict aSCs to a homeostatic function in animals with fixed adult size.
Beschreibung:Gesehen am 23.07.2019
Beschreibung:Online Resource
ISSN:2050-084X
DOI:10.7554/eLife.43747

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