Von der Paneldiagnostik zu umfassenden genomischen Analysen
Precision oncology is obtaining a central role in the therapy of malignant diseases. The indication for targeted therapy is based on the identification of molecular targets for which next-generation sequencing (NGS) is commonly used nowadays. All approved predictive biomarkers and molecular targets,...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Deutsch |
| Veröffentlicht: |
14. Mai 2019
|
| In: |
Der Pathologe
Year: 2019, Jahrgang: 40, Heft: 3, Pages: 235-242 |
| ISSN: | 1432-1963 |
| DOI: | 10.1007/s00292-019-0608-1 |
| Online-Zugang: | Verlag, Volltext: https://doi.org/10.1007/s00292-019-0608-1
|
| Verfasserangaben: | J. Leichsenring, D. Kazdal, C. Ploeger, M. Allgäuer, V. Endris, A.‑L. Volckmar, O. Neumann, M. Kirchner, R. Penzel, E. Rempel, J. Budczies, P. Schirmacher, S. Fröhling, A. Stenzinger |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1670171574 | ||
| 003 | DE-627 | ||
| 005 | 20230427055705.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 190729s2019 xx |||||o 00| ||ger c | ||
| 024 | 7 | |a 10.1007/s00292-019-0608-1 |2 doi | |
| 035 | |a (DE-627)1670171574 | ||
| 035 | |a (DE-599)KXP1670171574 | ||
| 035 | |a (OCoLC)1341234922 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a ger | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Leichsenring, Jonas |d 1985- |e VerfasserIn |0 (DE-588)112053464X |0 (DE-627)873481879 |0 (DE-576)480419272 |4 aut | |
| 245 | 1 | 0 | |a Von der Paneldiagnostik zu umfassenden genomischen Analysen |c J. Leichsenring, D. Kazdal, C. Ploeger, M. Allgäuer, V. Endris, A.‑L. Volckmar, O. Neumann, M. Kirchner, R. Penzel, E. Rempel, J. Budczies, P. Schirmacher, S. Fröhling, A. Stenzinger |
| 264 | 1 | |c 14. Mai 2019 | |
| 300 | |a 8 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 29.07.2019 | ||
| 520 | |a Precision oncology is obtaining a central role in the therapy of malignant diseases. The indication for targeted therapy is based on the identification of molecular targets for which next-generation sequencing (NGS) is commonly used nowadays. All approved predictive biomarkers and molecular targets, including gene fusions and copy number alterations, can be identified depending on panel design and method applied. Some clinical scenarios, however, may require more holistic genomic approaches, such as whole-genome/whole-exome and transcriptome analysis, which must be embedded in a clinical trial. Here, key aspects and applications of each method are summarized and discussed. | ||
| 650 | 4 | |a DNA copy number variations | |
| 650 | 4 | |a DNA mutational analysis | |
| 650 | 4 | |a DNA-Kopienzahl-Veränderungen | |
| 650 | 4 | |a DNA-Mutationsanalyse | |
| 650 | 4 | |a Ganzgenomsequenzierung | |
| 650 | 4 | |a Gene expression profiling | |
| 650 | 4 | |a Genexpressionsprofiling | |
| 650 | 4 | |a High-throughput nucleotide sequencing | |
| 650 | 4 | |a Hochdurchsatz-Nukleotidsequenzierung | |
| 650 | 4 | |a Whole genome sequencing | |
| 700 | 1 | |a Kazdal, Daniel |d 1983- |e VerfasserIn |0 (DE-588)114929650X |0 (DE-627)1009614088 |0 (DE-576)496635867 |4 aut | |
| 700 | 1 | |a Plöger, Carolin |e VerfasserIn |0 (DE-588)1131886453 |0 (DE-627)886934788 |0 (DE-576)488553814 |4 aut | |
| 700 | 1 | |a Allgäuer, Michael |e VerfasserIn |0 (DE-588)1178366790 |0 (DE-627)1049312597 |0 (DE-576)517751453 |4 aut | |
| 700 | 1 | |a Endris, Volker |e VerfasserIn |0 (DE-588)1063753686 |0 (DE-627)812590961 |0 (DE-576)422898198 |4 aut | |
| 700 | 1 | |a Volckmar, Anna-Lena |d 1984- |e VerfasserIn |0 (DE-588)173874916 |0 (DE-627)698776666 |0 (DE-576)134713478 |4 aut | |
| 700 | 1 | |a Neumann, Olaf |e VerfasserIn |0 (DE-588)1033375632 |0 (DE-627)741119498 |0 (DE-576)380962381 |4 aut | |
| 700 | 1 | |a Kirchner, Matthias |e VerfasserIn |0 (DE-588)1170116590 |0 (DE-627)1037105613 |0 (DE-576)512394849 |4 aut | |
| 700 | 1 | |a Penzel, Roland |e VerfasserIn |0 (DE-588)102044021X |0 (DE-627)691221316 |0 (DE-576)360421083 |4 aut | |
| 700 | 1 | |a Rempel, Eugen |d 1979- |e VerfasserIn |0 (DE-588)1116610396 |0 (DE-627)870570269 |0 (DE-576)478523572 |4 aut | |
| 700 | 1 | |a Budczies, Jan |d 1970- |e VerfasserIn |0 (DE-588)124086403 |0 (DE-627)706532724 |0 (DE-576)186167679 |4 aut | |
| 700 | 1 | |a Schirmacher, Peter |d 1961- |e VerfasserIn |0 (DE-588)1020440112 |0 (DE-627)691221197 |0 (DE-576)360427448 |4 aut | |
| 700 | 1 | |a Fröhling, Stefan |d 1969- |e VerfasserIn |0 (DE-588)120890046 |0 (DE-627)080950302 |0 (DE-576)188733930 |4 aut | |
| 700 | 1 | |a Stenzinger, Albrecht |e VerfasserIn |0 (DE-588)139606106 |0 (DE-627)703395238 |0 (DE-576)312432755 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Der Pathologe |d Berlin : Springer, 1994 |g 40(2019), 3, Seite 235-242 |h Online-Ressource |w (DE-627)25463866X |w (DE-600)1462980-X |w (DE-576)074531603 |x 1432-1963 |7 nnas |a Von der Paneldiagnostik zu umfassenden genomischen Analysen |
| 773 | 1 | 8 | |g volume:40 |g year:2019 |g number:3 |g pages:235-242 |g extent:8 |a Von der Paneldiagnostik zu umfassenden genomischen Analysen |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s00292-019-0608-1 |x Verlag |x Resolving-System |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20190729 | ||
| 994 | |a 2019 | ||
| 998 | |g 139606106 |a Stenzinger, Albrecht |m 139606106:Stenzinger, Albrecht |d 910000 |d 912000 |e 910000PS139606106 |e 912000PS139606106 |k 0/910000/ |k 1/910000/912000/ |p 14 |y j | ||
| 998 | |g 120890046 |a Fröhling, Stefan |m 120890046:Fröhling, Stefan |d 50000 |e 50000PF120890046 |k 0/50000/ |p 13 | ||
| 998 | |g 1020440112 |a Schirmacher, Peter |m 1020440112:Schirmacher, Peter |d 910000 |d 912000 |e 910000PS1020440112 |e 912000PS1020440112 |k 0/910000/ |k 1/910000/912000/ |p 12 | ||
| 998 | |g 124086403 |a Budczies, Jan |m 124086403:Budczies, Jan |d 910000 |d 912000 |e 910000PB124086403 |e 912000PB124086403 |k 0/910000/ |k 1/910000/912000/ |p 11 | ||
| 998 | |g 1116610396 |a Rempel, Eugen |m 1116610396:Rempel, Eugen |d 910000 |d 912000 |e 910000PR1116610396 |e 912000PR1116610396 |k 0/910000/ |k 1/910000/912000/ |p 10 | ||
| 998 | |g 102044021X |a Penzel, Roland |m 102044021X:Penzel, Roland |d 910000 |d 912000 |e 910000PP102044021X |e 912000PP102044021X |k 0/910000/ |k 1/910000/912000/ |p 9 | ||
| 998 | |g 1170116590 |a Kirchner, Matthias |m 1170116590:Kirchner, Matthias |d 910000 |d 912000 |e 910000PK1170116590 |e 912000PK1170116590 |k 0/910000/ |k 1/910000/912000/ |p 8 | ||
| 998 | |g 1033375632 |a Neumann, Olaf |m 1033375632:Neumann, Olaf |d 910000 |d 912000 |e 910000PN1033375632 |e 912000PN1033375632 |k 0/910000/ |k 1/910000/912000/ |p 7 | ||
| 998 | |g 173874916 |a Volckmar, Anna-Lena |m 173874916:Volckmar, Anna-Lena |d 910000 |d 912000 |e 910000PV173874916 |e 912000PV173874916 |k 0/910000/ |k 1/910000/912000/ |p 6 | ||
| 998 | |g 1063753686 |a Endris, Volker |m 1063753686:Endris, Volker |d 910000 |d 912000 |e 910000PE1063753686 |e 912000PE1063753686 |k 0/910000/ |k 1/910000/912000/ |p 5 | ||
| 998 | |g 1178366790 |a Allgäuer, Michael |m 1178366790:Allgäuer, Michael |d 910000 |d 912000 |e 910000PA1178366790 |e 912000PA1178366790 |k 0/910000/ |k 1/910000/912000/ |p 4 | ||
| 998 | |g 1131886453 |a Plöger, Carolin |m 1131886453:Plöger, Carolin |d 910000 |d 912000 |e 910000PP1131886453 |e 912000PP1131886453 |k 0/910000/ |k 1/910000/912000/ |p 3 | ||
| 998 | |g 114929650X |a Kazdal, Daniel |m 114929650X:Kazdal, Daniel |d 910000 |d 912000 |e 910000PK114929650X |e 912000PK114929650X |k 0/910000/ |k 1/910000/912000/ |p 2 | ||
| 998 | |g 112053464X |a Leichsenring, Jonas |m 112053464X:Leichsenring, Jonas |d 910000 |d 912000 |e 910000PL112053464X |e 912000PL112053464X |k 0/910000/ |k 1/910000/912000/ |p 1 |x j | ||
| 999 | |a KXP-PPN1670171574 |e 3499617358 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"recId":"1670171574","person":[{"family":"Leichsenring","role":"aut","given":"Jonas","display":"Leichsenring, Jonas"},{"given":"Daniel","display":"Kazdal, Daniel","role":"aut","family":"Kazdal"},{"display":"Plöger, Carolin","given":"Carolin","family":"Plöger","role":"aut"},{"display":"Allgäuer, Michael","given":"Michael","family":"Allgäuer","role":"aut"},{"given":"Volker","display":"Endris, Volker","role":"aut","family":"Endris"},{"family":"Volckmar","role":"aut","display":"Volckmar, Anna-Lena","given":"Anna-Lena"},{"family":"Neumann","role":"aut","given":"Olaf","display":"Neumann, Olaf"},{"family":"Kirchner","role":"aut","given":"Matthias","display":"Kirchner, Matthias"},{"display":"Penzel, Roland","given":"Roland","family":"Penzel","role":"aut"},{"display":"Rempel, Eugen","given":"Eugen","family":"Rempel","role":"aut"},{"family":"Budczies","role":"aut","display":"Budczies, Jan","given":"Jan"},{"given":"Peter","display":"Schirmacher, Peter","family":"Schirmacher","role":"aut"},{"role":"aut","family":"Fröhling","given":"Stefan","display":"Fröhling, Stefan"},{"role":"aut","family":"Stenzinger","given":"Albrecht","display":"Stenzinger, Albrecht"}],"note":["Gesehen am 29.07.2019"],"name":{"displayForm":["J. Leichsenring, D. Kazdal, C. Ploeger, M. Allgäuer, V. Endris, A.‑L. Volckmar, O. Neumann, M. Kirchner, R. Penzel, E. Rempel, J. Budczies, P. Schirmacher, S. Fröhling, A. Stenzinger"]},"language":["ger"],"relHost":[{"origin":[{"publisherPlace":"Berlin ; Heidelberg ; New York","publisher":"Springer","dateIssuedDisp":"[1994?-2022]"}],"physDesc":[{"extent":"Online-Ressource"}],"id":{"issn":["1432-1963"],"eki":["25463866X"],"zdb":["1462980-X"]},"title":[{"title_sort":"Pathologe","subtitle":"Organ der Deutschen Abteilung der Internationalen Akademie für Pathologie, der Deutschen, der Österreichischen und der Schweizerischen Gesellschaft für Pathologie und des Berufsverbandes Deutscher Pathologen","title":"Der Pathologe"}],"recId":"25463866X","disp":"Von der Paneldiagnostik zu umfassenden genomischen AnalysenDer Pathologe","type":{"bibl":"periodical","media":"Online-Ressource"},"note":["Gesehen am 05.07.2022","Teils ungezählte Beil.: Supplement"],"pubHistory":["Volume 15, issue 1 (February 1994) [?]-volume 43, issue 3 (May 2022)"],"part":{"year":"2019","volume":"40","text":"40(2019), 3, Seite 235-242","extent":"8","pages":"235-242","issue":"3"},"language":["ger","eng"]}],"origin":[{"dateIssuedDisp":"14. Mai 2019","dateIssuedKey":"2019"}],"title":[{"title_sort":"Von der Paneldiagnostik zu umfassenden genomischen Analysen","title":"Von der Paneldiagnostik zu umfassenden genomischen Analysen"}],"type":{"media":"Online-Ressource","bibl":"article-journal"},"id":{"doi":["10.1007/s00292-019-0608-1"],"eki":["1670171574"]},"physDesc":[{"extent":"8 S."}]} | ||
| SRT | |a LEICHSENRIVONDERPANE1420 | ||