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Functionalizable composite nanoparticles as a dual magnetic resonance imaging/computed tomography contrast agent for medical imaging

A dual contrast agent for computed tomography (CT) and magnetic resonance imaging (MRI) was synthesized via microemulsion polymerization. This contrast agent consists of Fe3O4 particles (d = 7 nm) with an iodine-carrying nanopolymeric shell, with overall particle sizes ranging from 50 to 250 nm. 2-M...

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Bibliographic Details
Main Authors: Illert, Patrick (Author) , Wängler, Björn (Author) , Pretze, Marc (Author) , Wängler, Carmen (Author) , Zöllner, Frank G. (Author) , Uhrig, Tanja (Author) , Litau, Shanna (Author)
Format: Article (Journal)
Language:English
Published: 31 January 2019
In: Journal of applied polymer science
Year: 2019, Volume: 136, Issue: 19
ISSN:1097-4628
DOI:10.1002/app.47571
Online Access:Verlag, Volltext: https://doi.org/10.1002/app.47571
Verlag, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/app.47571
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Author Notes:Patrick Illert, Björn Wängler, Carmen Wängler, Frank Zöllner, Tanja Uhrig, Shanna Litau, Marc Pretze, Thorsten Röder
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Summary:A dual contrast agent for computed tomography (CT) and magnetic resonance imaging (MRI) was synthesized via microemulsion polymerization. This contrast agent consists of Fe3O4 particles (d = 7 nm) with an iodine-carrying nanopolymeric shell, with overall particle sizes ranging from 50 to 250 nm. 2-Methacryloyloxyethyl(2,3,5-triiodobenzoate) was used as the monomer. Sodium oleate was used as the surfactant and its amount was varied to control the overall particle size. The composite nanoparticles were mainly characterized via dynamic light scattering, with further analyses using transmission electron microscopy and atomic force microscopy. The particles provided a highly visible contrast in CT and MR images. A template for biomedical applications was created by adding a comonomer and the particles were further functionalized with the somatostatin analogue Tyr3-octreotate. The particles were tested for specific uptake into somatostatin receptor-positive AR42J cells. The additional uptake of the functionalized particles was investigated. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 47571.
Item Description:Gesehen am 01.08.2019
Physical Description:Online Resource
ISSN:1097-4628
DOI:10.1002/app.47571

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